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Clinical Trials for Sarcoma
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There are 151 active trials for advanced/metastatic sarcoma.
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Pilot Pharmacokinetic Study of VAL-413 (Orotecan®) in Patients With Recurrent Pediatric Solid Tumors
No known activity
High burden on patient
Started >3 years ago
No investigational drug(s) in this trial have shown anticancer activity yet in clinical trials
The trial has a high burden on patients. An example would be a phase 1 trial with extra tumor biopsies and frequent pharmacokinetic blood draws.
The trial was activated more than 3 years ago. This is not always bad but can indicate that the trial has less current treatments, or has had trouble getting enough patients to enroll due to other issues.
Sponsor: Valent Technologies, LLC (industry)
Phase: 1
Start date: Oct. 25, 2021
HealthScout AI summary: Enrolling children, adolescents, and young adults (1–≤30 years) with recurrent/refractory solid or CNS tumors lacking curative options, including those previously exposed to irinotecan/temozolomide if not refractory. Patients receive a flavored oral irinotecan formulation (VAL-413, prodrug converted to SN-38 topoisomerase I inhibitor) plus oral temozolomide in 5-day, 21-day cycles, with a cycle 1 PK comparison dose of orally administered IV irinotecan solution.
ClinicalTrials.gov ID: NCT04337177