Clinical Trials for Ovarian Cancer

A Phase 1/2, Open-label, Dose-escalation Trial of Tumor Necrosis Factor Alpha and Interleukin-2 Coding Oncolytic Adenovirus (TILT-123) in Combination With Pembrolizumab (Phase 1 and Phase 2) and Pembrolizumab and Pegylated Liposomal Doxorubicin (Phase 1b) in Patients With Platinum Resistant or Refractory Ovarian Cancer

Active drug

Investigational drug(s) in this trial have shown anticancer activity in clinical trials

Started >3 years ago

The trial was activated more than 3 years ago. This is not always bad but can indicate that the trial has less current treatments, or has had trouble getting enough patients to enroll due to other issues.

High burden on patient

The trial has a high burden on patients. An example would be a phase 1 trial with extra tumor biopsies and frequent pharmacokinetic blood draws.

HealthScout AI summary: Adults with platinum-resistant or -refractory recurrent ovarian, fallopian tube, or primary peritoneal cancer with a lesion amenable to intratumoral/intraperitoneal injection receive the oncolytic adenovirus TILT-123 (igrelimogene litadenorepvec; tumor-selective adenovirus expressing TNFα and IL-2 to inflame TME and recruit/activate T cells) plus pembrolizumab, with a cohort also adding pegylated liposomal doxorubicin. Suitable for ECOG 0–1 patients without active autoimmune disease; Phase 1/1b defines dose and evaluates the triplet, and Phase 2 expands TILT-123 + pembrolizumab.

ClinicalTrials.gov ID: NCT05271318

Randomized, Multicenter, Open-label, Phase 3 Study of Mirvetuximab Soravtansine in Combination With Bevacizumab Versus Bevacizumab Alone as Maintenance Therapy for Patients With FRα-high Recurrent Platinum-sensitive Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancers Who Have Not Progressed After Second Line Platinum-based Chemotherapy Plus Bevacizumab

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

HealthScout AI summary: Maintenance trial for adult women with FRα-high, platinum-sensitive recurrent high-grade serous ovarian/fallopian tube/primary peritoneal cancer who have not progressed after second-line platinum plus bevacizumab, randomized to bevacizumab alone vs bevacizumab plus mirvetuximab soravtansine (an FRα-targeted antibody–drug conjugate delivering the microtubule-disrupting payload DM4). Excludes non–high-grade serous histologies, progression on platinum, prior FRα-targeted therapy, significant ocular disease, and untreated/symptomatic CNS metastases.

ClinicalTrials.gov ID: NCT05445778

A Phase 1b Study of ZN-c3 in Combination With Chemotherapy or Bevacizumab in Subjects With Ovarian, Peritoneal, or Fallopian Tube Cancer

Active drug

Investigational drug(s) in this trial have shown anticancer activity in clinical trials

Started >3 years ago

The trial was activated more than 3 years ago. This is not always bad but can indicate that the trial has less current treatments, or has had trouble getting enough patients to enroll due to other issues.

High burden on patient

The trial has a high burden on patients. An example would be a phase 1 trial with extra tumor biopsies and frequent pharmacokinetic blood draws.

HealthScout AI summary: Recurrent high‑grade serous epithelial ovarian, fallopian tube, or primary peritoneal cancer after 1–2 prior lines, measurable disease, enrolling to receive the oral WEE1 kinase inhibitor azenosertib (ZN‑c3) combined with standard relapse regimens (carboplatin, PLD, paclitaxel, gemcitabine) or bevacizumab. WEE1 inhibition abrogates G2/M and intra‑S checkpoints to force mitotic catastrophe; study is multi‑arm dose‑escalation/expansion to define safe doses and assess preliminary activity.

ClinicalTrials.gov ID: NCT04516447

A Phase III Trial of One vs. Two Years of Maintenance Olaparib, With or Without Bevacizumab, in Patients With BRCA1/2 Mutated or Homologous Recombination Deficient (HRD+) Ovarian Cancer Following Response to First Line Platinum-Based Chemotherapy

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

HealthScout AI summary: Adults with newly diagnosed FIGO stage III–IV high‑grade serous/endometrioid ovarian, fallopian tube, or primary peritoneal cancer with pathogenic BRCA1/2 mutation or HRD+ status after response to first‑line platinum are randomized to maintenance olaparib for 1 year vs 2 years, with optional bevacizumab. Olaparib is an oral PARP1/2 inhibitor exploiting HRD via synthetic lethality; bevacizumab is an anti‑VEGF monoclonal antibody given at physician discretion for up to 1 year.

ClinicalTrials.gov ID: NCT06580314

Combination Therapy With Liposomal Doxorubicin and Withaferin A (Ashwagandha, ASWD) in Recurrent Ovarian Cancer

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

HealthScout AI summary: Adults with platinum-resistant or refractory recurrent epithelial ovarian, fallopian tube, or primary peritoneal carcinoma eligible for single-agent liposomal doxorubicin receive DOXIL 40 mg/m2 q4wk plus daily oral Ashwagandha (withaferin A–rich extract) at the phase I–selected dose. Withaferin A is a multi-target botanical agent (NF-κB inhibition, ER stress induction, cytoskeletal disruption) combined with standard DOXIL to assess safety and early efficacy; excludes prior anthracyclines/liposomal doxorubicin and significant cardiac disease (LVEF ≥55% required).

ClinicalTrials.gov ID: NCT05610735

A Phase 3, Open-label, Multicenter, Randomized Trial of Trastuzumab Deruxtecan With Bevacizumab Versus Bevacizumab Monotherapy as First-line Maintenance Therapy in HER2-Expressing Ovarian Cancer (DESTINY-Ovarian01/ENGOT-ov89/GEICO144- O/GOG-3112)

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

HealthScout AI summary: Adults with newly diagnosed FIGO III–IV high-grade epithelial ovarian/fallopian tube/primary peritoneal carcinoma whose tumors express HER2 (IHC 3+/2+/1+) and who completed frontline platinum plus bevacizumab are randomized to maintenance trastuzumab deruxtecan (HER2-targeted antibody–drug conjugate delivering a topoisomerase I inhibitor) plus bevacizumab versus bevacizumab alone. Excludes patients with BRCA mutations or on PARP maintenance and those with significant bleeding risk or prior/current ILD/pneumonitis.

ClinicalTrials.gov ID: NCT06819007

Phase 1/2a Open-Label, Dose-Escalation, Multicenter, FIH, Consecutive-Cohort, Clinical Trial of BI-1808, a Monoclonal Antibody to TNFR 2 As a Single Agent and in Combination with Pembrolizumab (MK-3475-D20) in Subjects with Advanced Malignancies

Active drug

Investigational drug(s) in this trial have shown anticancer activity in clinical trials

Started >3 years ago

The trial was activated more than 3 years ago. This is not always bad but can indicate that the trial has less current treatments, or has had trouble getting enough patients to enroll due to other issues.

High burden on patient

The trial has a high burden on patients. An example would be a phase 1 trial with extra tumor biopsies and frequent pharmacokinetic blood draws.

HealthScout AI summary: Adults with advanced solid tumors or T‑cell lymphomas (including CTCL) after failure/intolerance of standard therapy, ECOG 0–1, measurable disease, and biopsy‑amenable tumors receive BI‑1808, a human IgG1 anti‑TNFR2 antibody that blocks TNF‑α/TNFR2 signaling and may deplete TNFR2+ Tregs, given IV every 3 weeks as monotherapy or combined with pembrolizumab. Excludes active CNS metastases, significant autoimmune disease, recent anticancer therapy, or active infections; expansion cohorts include ovarian cancer, melanoma, and T‑cell lymphomas.

ClinicalTrials.gov ID: NCT04752826

Phase II Study of Nab-sirolimus and Endocrine Therapy in Recurrent Low Grade Serous Ovarian Cancer

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

HealthScout AI summary: Adults with recurrent, histologically confirmed low-grade serous ovarian cancer (ECOG 0–1; measurable disease; prior MEK inhibitor allowed; ≤1 prior cytotoxic regimen; no prior mTOR/PI3K/AKT inhibitors) receive nab-sirolimus (albumin-bound mTOR inhibitor targeting PI3K/AKT/mTOR) IV plus fulvestrant (SERD) IM until progression or toxicity. Single-arm study with required pre-dose biopsy; key exclusions include significant cardiopulmonary disease, active uncontrolled infections, CNS disease needing recent steroids/RT, and strong CYP3A4 interactions.

ClinicalTrials.gov ID: NCT06494150

A Phase II Evaluation of Maintenance Therapy Combination Mirvetuximab Soravtansine and Olaparib in Recurrent Platinum Sensitive Ovarian, Peritoneal, and Fallopian Tube Cancer

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

HealthScout AI summary: Maintenance combination of mirvetuximab soravtansine (FRα-targeted antibody–drug conjugate delivering DM4) plus olaparib (PARP inhibitor) for adult women with platinum-sensitive recurrent high-grade serous or endometrioid ovarian, primary peritoneal, or fallopian tube cancer who have CR/PR/SD after platinum and medium/high FRα expression (BRCA-mutated patients must have had prior PARP). Treatment continues until progression or toxicity; key exclusions include prior FRα-targeted therapy, CNS mets, significant ocular disease, and use of strong/moderate CYP3A modifiers.

ClinicalTrials.gov ID: NCT05887609

Phase II Clinical Trial Repurposing Atovaquone for the Treatment of Platinum-Resistant Ovarian Cancer

Moderate burden on patient

The trial has a moderate burden on patients. An example would be a trial testing an IV drug, with scans every 8 weeks which would be more frequent than standard of care.

HealthScout AI summary: Adults with platinum-resistant high-grade serous ovarian cancer (progression within 6 months of last platinum; ECOG 0–1; any prior lines) receive oral atovaquone monotherapy. Atovaquone, an antiprotozoal repurposed here for its STAT3 pathway inhibition, is assessed for progression-free survival with correlative biopsies/ascites and imaging to evaluate on-target effects and immune microenvironment changes.

ClinicalTrials.gov ID: NCT05998135