Clinical Trials for Other Solid Tumor

An Open-label, Phase 1, Multicenter Study to Evaluate the Safety and Preliminary Anti-tumor Activity of NT-112 in Human Leukocyte Antigen-C*08:02-Positive Adult Subjects with Unresectable, Advanced, And/or Metastatic Solid Tumors That Are Positive for the KRAS G12D Mutation

No known activity

No investigational drug(s) in this trial have shown anticancer activity yet in clinical trials

High burden on patient

The trial has a high burden on patients. An example would be a phase 1 trial with extra tumor biopsies and frequent pharmacokinetic blood draws.

HealthScout AI summary: This trial evaluates NT-112, an autologous engineered T-cell therapy targeting KRAS G12D mutations in HLA-C*08:02-positive adults with advanced solid tumors, including non-small cell lung, colorectal, pancreatic, and endometrial cancer, following lymphodepletion and IL-2 treatment.

ClinicalTrials.gov ID: NCT06218914

An Open-Label, Phase 1b/2a Study of SLC-391, an AXL Inhibitor, in Combination with Pembrolizumab in Subjects with Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC)

No known activity

No investigational drug(s) in this trial have shown anticancer activity yet in clinical trials

High burden on patient

The trial has a high burden on patients. An example would be a phase 1 trial with extra tumor biopsies and frequent pharmacokinetic blood draws.

HealthScout AI summary: This trial involves adult patients with advanced or metastatic non-small cell lung cancer (NSCLC), exploring the combination of SLC-391, a selective AXL receptor tyrosine kinase inhibitor, with pembrolizumab, a PD-1 checkpoint inhibitor, in both treatment-naïve patients and those with progression after prior therapies.

ClinicalTrials.gov ID: NCT05860296

A Phase 1/1b First-In-Human, Multi-Part, Open-Label Study to Investigate the Safety, Tolerability, Pharmacokinetics, Biological, and Clinical Activity of DF9001 as a Monotherapy and in Combination Therapies in Patients With Advanced (Unresectable, Recurrent, or Metastatic) Solid Tumors, and Expansion in Selected Indications

No known activity

No investigational drug(s) in this trial have shown anticancer activity yet in clinical trials

High burden on patient

The trial has a high burden on patients. An example would be a phase 1 trial with extra tumor biopsies and frequent pharmacokinetic blood draws.

HealthScout AI summary: This trial evaluates the investigational drug DF9001, a multi-specific immunotherapy targeting EGFR signaling and immune cell activation, administered alone or with pembrolizumab, in adults with advanced solid tumors expressing EGFR, including NSCLC, HNSCC, and RCC, following disease progression after prior therapies.

ClinicalTrials.gov ID: NCT05597839

A Phase 1, First-in-Human, Open-Label, Multi-Center, Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of LB-LR1109 for the Treatment of Advanced or Metastatic Solid Tumors

No known activity

No investigational drug(s) in this trial have shown anticancer activity yet in clinical trials

High burden on patient

The trial has a high burden on patients. An example would be a phase 1 trial with extra tumor biopsies and frequent pharmacokinetic blood draws.

HealthScout AI summary: The trial is for adult patients with advanced or metastatic non-small cell lung cancer, head and neck squamous cell carcinoma, renal cell carcinoma, urothelial carcinoma, or malignant melanoma who have no remaining standard treatment options, and it evaluates the safety, tolerability, and dosing of the investigational drug LB-LR1109, administered intravenously.

ClinicalTrials.gov ID: NCT06332755

A Phase 1/2, Open-Label Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Anti-Tumor Activity of FWD1509 MsOH in Advanced Non-Small Cell Lung Cancer

High burden on patient

The trial has a high burden on patients. An example would be a phase 1 trial with extra tumor biopsies and frequent pharmacokinetic blood draws.

Started >3 years ago

The trial was activated more than 3 years ago. This is not always bad but can indicate that the trial has less current treatments, or has had trouble getting enough patients to enroll due to other issues.

HealthScout AI summary: This trial involves adult patients with advanced NSCLC featuring EGFR or HER2 mutations, who have progressed on or are intolerant to existing therapies, and investigates FWD1509 MsOH, an oral tyrosine kinase inhibitor targeting EGFR and HER2 mutations, including exon 19 deletions, L858R, T790M, and EGFRex20ins.

ClinicalTrials.gov ID: NCT05068024

An Open-label, Phase 1, First-in-human, Dose Escalation and Expansion Study to Evaluate the Safety, Tolerability, Maximum Tolerated or Administered Dose, Pharmacokinetics, Pharmacodynamics, and Tumor Response Profile of the Diacylglycerol Kinase Zeta Inhibitor (DGKzi) BAY 2965501 as Monotherapy, and in Combination, in Participants With Advanced Solid Tumors

No known activity

No investigational drug(s) in this trial have shown anticancer activity yet in clinical trials

High burden on patient

The trial has a high burden on patients. An example would be a phase 1 trial with extra tumor biopsies and frequent pharmacokinetic blood draws.

HealthScout AI summary: This trial enrolls patients with advanced solid tumors, including non-small cell lung cancer and gastric adenocarcinoma, to evaluate the safety and efficacy of BAY2965501, a DGKζ inhibitor targeting diacylglycerol kinases to enhance T-cell-mediated anti-tumor activity, both as monotherapy and in combination with pembrolizumab and platinum-based chemotherapy. Participants must have an ECOG performance status of 0-1 and meet specific disease criteria, with exclusions for primary CNS malignancies or uncontrolled brain metastases.

ClinicalTrials.gov ID: NCT05614102

Phase 1/2a Open-Label, Dose-Escalation, Multicenter, First-in-Human, Consecutive-Cohort, Clinical Trial of BI-1910, a Monoclonal Antibody to Tumor Necrosis Factor Receptor 2 (TNFR2), as a Single Agent and in Combination With Pembrolizumab in Subjects With Advanced Solid Tumors

No known activity

No investigational drug(s) in this trial have shown anticancer activity yet in clinical trials

High burden on patient

The trial has a high burden on patients. An example would be a phase 1 trial with extra tumor biopsies and frequent pharmacokinetic blood draws.

HealthScout AI summary: This trial involves patients aged 18 and older with advanced/metastatic solid tumors, exploring BI-1910, a monoclonal antibody targeting TNFR2 to activate T and NK cells, alone and in combination with pembrolizumab, particularly for those who have progressed after or are ineligible for standard therapies.

ClinicalTrials.gov ID: NCT06205706

C-TIL051 in Anti-PD1 Resistant Metastatic Non-Small Cell Lung Cancer

No known activity

No investigational drug(s) in this trial have shown anticancer activity yet in clinical trials

High burden on patient

The trial has a high burden on patients. An example would be a phase 1 trial with extra tumor biopsies and frequent pharmacokinetic blood draws.

HealthScout AI summary: The trial targets patients with stage IV or recurrent NSCLC resistant to anti-PD1 therapy, using a combination of C-TIL051 (engineered tumor-infiltrating lymphocytes), NKTR-255 (IL-15 receptor agonist), and Pembrolizumab to enhance immune response. Participants must have adenocarcinoma or squamous histology, measurable disease, and no prior PD1/PDL1 inhibitor treatment for metastatic disease.

ClinicalTrials.gov ID: NCT05676749

A Phase 1a/1b Study of ELVN-002 for the Treatment of Patients with HER2 Mutant Non-Small Cell Lung Cancer

No known activity

No investigational drug(s) in this trial have shown anticancer activity yet in clinical trials

High burden on patient

The trial has a high burden on patients. An example would be a phase 1 trial with extra tumor biopsies and frequent pharmacokinetic blood draws.

HealthScout AI summary: The trial is enrolling patients with advanced-stage solid tumors, including HER2-mutant non-small cell lung cancer and HER2-positive metastatic breast cancer, to evaluate the safety and efficacy of ELVN-002, a novel oral tyrosine kinase inhibitor targeting HER2 and multiple HER2 mutations, as a monotherapy and in combination with standard treatments.

ClinicalTrials.gov ID: NCT05650879

A Phase 1 Dose Escalation and Cohort Expansion Study of TSR-042, an Anti-PD-1 Monoclonal Antibody, in Patients With Advanced Solid Tumors

High burden on patient

The trial has a high burden on patients. An example would be a phase 1 trial with extra tumor biopsies and frequent pharmacokinetic blood draws.

Started >3 years ago

The trial was activated more than 3 years ago. This is not always bad but can indicate that the trial has less current treatments, or has had trouble getting enough patients to enroll due to other issues.

HealthScout AI summary: This trial investigates dostarlimab, an anti-PD-1 monoclonal antibody, in adults with advanced solid tumors who have progressed despite prior treatments, focusing on specific cohorts such as endometrial cancer, non-small cell lung cancer, ovarian cancer, and tumors with mismatch repair deficiencies. Participants should have limited viable treatment options.

ClinicalTrials.gov ID: NCT02715284