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There are 397 active trials for advanced/metastatic other solid tumor. Click on a trial to see more information. Note that this list also includes some trials that are only for specific cancer types like lung cancer. To see trials customized to a patient, please select a patient above.
397 trials meet filter criteria.
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HealthScout AI summary: This trial enrolls adults with recurrent unresectable, locally advanced, or metastatic solid tumors that express EGFR and have lost HLA-A*02 expression, including types such as CRC, NSCLC, HNSCC, TNBC, and RCC, and tests A2B395, a logic-gated Tmod™ CAR T-cell therapy designed to selectively target these tumor cells while sparing healthy cells. Participants receive a preconditioning lymphodepletion regimen followed by a single intravenous dose of A2B395.
ClinicalTrials.gov ID: NCT06682793
HealthScout AI summary: This trial involves adult patients with advanced or metastatic ER+ HER2- breast cancer, castration-resistant prostate cancer, or non-small cell lung cancer, focusing on those who have exhausted available therapies; it investigates OP-3136, an oral small molecule inhibitor of lysine acetyltransferases 6A and 6B, for safety, pharmacokinetics, and preliminary efficacy.
ClinicalTrials.gov ID: NCT06784193
HealthScout AI summary: This trial involves patients with unresectable, locally advanced, or metastatic solid tumors expressing Nectin-4, who have exhausted other treatment options, receiving the investigational antibody-drug conjugate IPH4502, which targets Nectin-4 with unique epitope binding and an exatecan payload to enhance anti-tumor effects.
ClinicalTrials.gov ID: NCT06781983
HealthScout AI summary: This trial involves adult patients with advanced solid tumors or diffuse large B-cell lymphoma that are metastatic or unresponsive to standard treatments and evaluates the safety and efficacy of NX-1607, a CBL-B inhibitor, as monotherapy or in combination with paclitaxel.
ClinicalTrials.gov ID: NCT05107674
HealthScout AI summary: This trial evaluates the safety and maximum tolerated dose of INBRX-106, a hexavalent OX40 agonist antibody, both alone and in combination with pembrolizumab, in adult patients with locally advanced or metastatic solid tumors, including NSCLC, melanoma, and head and neck squamous cell carcinoma, who have progressed on standard therapies.
ClinicalTrials.gov ID: NCT04198766
HealthScout AI summary: This trial targets adult patients with advanced solid tumors, including NSCLC, melanoma, liposarcoma, leiomyosarcoma, and SCCHN, who have exhausted standard treatments. It evaluates OR2805, a monoclonal antibody targeting CD163 to modulate tumor-associated macrophages, administered alone or with cemiplimab or docetaxel.
ClinicalTrials.gov ID: NCT05094804
HealthScout AI summary: This trial assesses BT8009, a Bicycle Toxin Conjugate targeting Nectin-4, both as monotherapy and combined with pembrolizumab, in patients with advanced Nectin-4 expressing solid tumors such as urothelial carcinoma, breast, NSCLC, and ovarian cancers, who have progressed after prior treatment or lack standard therapy options. The study evaluates safety, pharmacokinetics, and preliminary efficacy, with previously reported promising response rates in treated urothelial cancer patients.
ClinicalTrials.gov ID: NCT04561362
HealthScout AI summary: The trial investigates the use of AG01, an anti-progranulin/GP88 monoclonal antibody, in patients with relapsed or refractory advanced solid tumors, including triple negative breast cancer, hormone-resistant breast cancer, non-small cell lung cancer, and mesothelioma, who have no remaining effective treatment options. AG01 is administered biweekly to evaluate its safety, tolerability, and preliminary anti-tumor activity.
ClinicalTrials.gov ID: NCT05627960
HealthScout AI summary: This trial is focused on patients with metastatic or locally advanced solid tumors, specifically colorectal cancer and non-small cell lung cancer, investigating the safety and efficacy of EU101, an agonistic monoclonal antibody targeting the 4-1BB receptor to enhance immune response.
ClinicalTrials.gov ID: NCT04903873
HealthScout AI summary: This trial targets patients with locally advanced or metastatic solid tumors, such as melanoma, non-small cell lung cancer, and triple-negative breast cancer, who have exhausted standard treatments, evaluating the safety and efficacy of DF6002, a monovalent IL-12 Fc fusion protein, both as a monotherapy and in combination with the PD-1 inhibitor Nivolumab. Eligible participants must have an ECOG performance status of 0 or 1 and adequate organ function.
ClinicalTrials.gov ID: NCT04423029