Clinical Trials for Non-Small Cell Lung Cancer

An Open-Label, Multiple-Dose, Dose-Escalation Study to Investigate the Safety, Pharmacokinetics, and Pharmacodynamics of VMD-928 in Subjects with Solid Tumors or Lymphoma

No known activity

No investigational drug(s) in this trial have shown anticancer activity yet in clinical trials

High burden on patient

The trial has a high burden on patients. An example would be a phase 1 trial with extra tumor biopsies and frequent pharmacokinetic blood draws.

Started >3 years ago

The trial was activated more than 3 years ago. This is not always bad but can indicate that the trial has less current treatments, or has had trouble getting enough patients to enroll due to other issues.

HealthScout AI summary: This trial investigates VMD-928, a selective TrkA inhibitor, in adult patients with advanced solid tumors or lymphoma that are resistant to existing therapies, focusing on those with TrkA overexpression or NTRK1 gene fusion.

ClinicalTrials.gov ID: NCT03556228

Open Label, Multi-center Roll-over Study to Assess Long Term Safety in Patients Who Have Completed a Global Novartis or GSK Sponsored Dabrafenib and/or Trametinib Study

Low burden on patient

The trial has a low burden on patients. An example would be a trial testing an oral drug, with scans every 12 weeks which would be similar to standard of care.

Started >3 years ago

The trial was activated more than 3 years ago. This is not always bad but can indicate that the trial has less current treatments, or has had trouble getting enough patients to enroll due to other issues.

Restricted enrollment

The trial has restricted enrollment. For instance, you may only be eligible to participate if you were enrolled in a specific prior trial.

HealthScout AI summary: This trial focuses on patients with BRAF V600 mutation-positive cancers who have previously shown clinical benefit from and are currently treated with the BRAF inhibitor dabrafenib, the MEK inhibitor trametinib, or their combination in a Novartis or GSK parent study, assessing the long-term safety of these treatments.

ClinicalTrials.gov ID: NCT03340506