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There are 386 active trials for advanced/metastatic non-small cell lung cancer. Click on a trial to see more information.
386 trials meet filter criteria.
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HealthScout AI summary: This trial involves adult patients with locally advanced or metastatic solid tumors lacking curative options and tests T-Plex, an autologous T cell therapy engineered to target specific peptide/HLA antigens like MAGE-A1 and HPV16 E7, administered alone or with lymphodepleting chemotherapy. The goal is to assess its safety, feasibility, and initial effectiveness in selectively targeting tumor cells expressing these antigens.
ClinicalTrials.gov ID: NCT05973487
HealthScout AI summary: This trial targets patients with metastatic solid cancers who have failed standard treatments, using autologous T-cells engineered to express T-cell receptors against neoantigens. It investigates the efficacy of these T-cells alone or combined with pembrolizumab, a PD-1 inhibitor, in reducing tumor size.
ClinicalTrials.gov ID: NCT03412877
HealthScout AI summary: This trial targets patients aged 18 and older with recurrent or metastatic non-small cell lung cancer who have failed prior chemotherapy and PD-1/PD-L1 therapies, testing the safety and efficacy of PBF-1129, an adenosine A2B receptor antagonist, combined with nivolumab, a PD-1 inhibitor.
ClinicalTrials.gov ID: NCT05234307
HealthScout AI summary: This trial evaluates FMC-376, a dual inhibitor of active and inactive KRAS G12C mutations, in patients with locally advanced unresectable or metastatic solid tumors who have progressed after or are intolerant to standard therapies. Eligible patients must have an ECOG performance status of 0 or 1, and the study includes dose escalation and expansion phases to assess safety, pharmacokinetics, and clinical activity.
ClinicalTrials.gov ID: NCT06244771
HealthScout AI summary: This trial involves patients with advanced or metastatic solid tumors with KRAS mutations or amplifications, assessing the investigational drug BGB-53038, a pan-KRAS inhibitor, both alone and in combination with the anti-PD-1 antibody tislelizumab and anti-EGFR antibody cetuximab.
ClinicalTrials.gov ID: NCT06585488
HealthScout AI summary: The trial investigates BGB-43395, a CDK4 inhibitor, alone or with fulvestrant or letrozole in patients with metastatic HR+/HER2- breast cancer and other advanced solid tumors reliant on CDK4, who are refractory or intolerant to standard therapies.
ClinicalTrials.gov ID: NCT06120283
HealthScout AI summary: The trial involves adult patients with locally advanced or metastatic NSCLC featuring EGFR mutations, specifically those resistant to third-generation EGFR TKIs like osimertinib due to C797X mutations but without T790M mutations, testing the safety and efficacy of STX-241, a fourth-generation EGFR TKI designed for resistance mutations.
ClinicalTrials.gov ID: NCT06567015
HealthScout AI summary: The trial involves patients with advanced, unresectable, or metastatic solid tumors who have exhausted standard therapies, testing VET3-TGI, an investigational oncolytic virus designed to target and destroy cancer cells, administered intratumorally or intravenously alone, and in combination with pembrolizumab, a PD-1 inhibitor.
ClinicalTrials.gov ID: NCT06444815
HealthScout AI summary: The trial involves adult patients with advanced or metastatic solid tumors, including breast, non-small cell lung, gastric, gastroesophageal, and colorectal cancers, receiving DM001, a bispecific antibody-drug conjugate targeting TROP2 and EGFR. The treatment seeks to establish dose tolerability and safety while employing a dual-targeting approach linking an antibody to a topoisomerase I inhibitor to enhance efficacy and reduce resistance.
ClinicalTrials.gov ID: NCT06475937
HealthScout AI summary: This trial involves patients aged 18 and over with advanced solid tumors exhibiting chromosomal instability, such as high-grade serous ovarian cancer, squamous non-small cell lung cancer, and triple negative breast cancer, who have limited therapeutic options. It assesses VLS-1488, an oral KIF18A inhibitor targeting mitotic processes in cancer cells, administered in 28-day cycles to determine its safety, tolerability, and efficacy.
ClinicalTrials.gov ID: NCT05902988
