Sponsor: AstraZeneca (industry)
Phase: 3
Start date: Nov. 21, 2023
Planned enrollment: 1800
Saruparib (AZD5305) is an investigational, first-in-class selective inhibitor of poly(ADP-ribose) polymerase 1 (PARP1), developed for treating cancers with homologous recombination repair (HRR) deficiencies, such as those harboring BRCA1/2, PALB2, or RAD51C/D mutations. (cancernetwork.com)
Saruparib selectively inhibits PARP1, an enzyme involved in DNA repair processes. By targeting PARP1 without affecting PARP2, saruparib aims to enhance therapeutic efficacy while reducing off-target effects associated with non-selective PARP inhibitors. (onclive.com)
In the phase 1/2a PETRA trial, saruparib demonstrated promising efficacy in patients with advanced solid tumors:
Responses were observed across various tumor types and HRR mutations, including both hormone receptor–positive and triple-negative breast cancers. (cancernetwork.com)
Saruparib exhibited a favorable safety profile:
The selective inhibition of PARP1 is believed to contribute to the improved safety profile compared to non-selective PARP inhibitors. (onclive.com)
Last updated: Apr 2025
Goal: To determine whether adding the PARP1-selective inhibitor saruparib (AZD5305) to a physician’s choice of next-generation hormonal agent improves radiographic progression-free survival versus placebo plus the same hormonal backbone in men with metastatic castration-sensitive prostate cancer (mCSPC), with planned evaluation in HRR-mutated (HRRm) and non-HRRm cohorts.
Patients: Adult men (≥18 years) with histologically confirmed metastatic castration-sensitive prostate adenocarcinoma, ECOG 0–1, on ADT or post-orchiectomy, with at least one evaluable bone or soft-tissue lesion. Key exclusions include small cell/neuroendocrine variants, prior systemic therapy for metastatic disease (with protocol-defined exceptions), significant hematologic disorders (e.g., MDS/AML, severe cytopenias), significant cardiovascular disease or arrhythmias, symptomatic/unstable CNS disease or spinal cord compression, uncontrolled GI conditions affecting absorption, and persistence of ≥ grade 2 toxicities from prior therapy. Central testing assigns patients to HRRm or non-HRRm cohorts.
Design: Global, double-blind, placebo-controlled, randomized phase III trial with two parallel cohorts (approximately 550 HRRm and 1250 non-HRRm). Patients are randomized 1:1 to saruparib plus new hormonal agent (NHA) versus placebo plus NHA, treated until progression or discontinuation. Survival follow-up continues to study end. Safety oversight by an independent data monitoring committee.
Treatments: Experimental arm: saruparib (AZD5305) combined with physician’s choice NHA (abiraterone, darolutamide, or enzalutamide). Control arm: placebo plus the same physician’s choice NHA. Saruparib is a next-generation, PARP1-selective inhibitor designed to retain antitumor efficacy while reducing hematologic toxicity associated with PARP2 inhibition. It traps PARP1 on DNA, inducing replication stress and genomic instability in tumors with homologous recombination repair deficiency. Early-phase PETRA data in HER2-negative breast cancer showed objective responses at the recommended phase 2 dose with a favorable hematologic safety profile compared with first-generation PARP inhibitors, supporting further evaluation in prostate cancer. Abiraterone, enzalutamide, and darolutamide are established androgen signaling–targeted therapies used as standard of care in mCSPC.
Outcomes: Primary: radiographic progression-free survival per RECIST 1.1 (soft tissue) and/or PCWG3 (bone), or death. Key secondary endpoints include overall survival, PFS2, time to first subsequent therapy or death, symptomatic skeletal event–free survival, time to first castration-resistant event, time to pain progression, and patient-reported outcomes including time to deterioration in urinary symptoms, fatigue, and physical function, as well as health-related quality of life measures. Additional endpoints include PSA response metrics, safety and tolerability (TEAEs/SAEs and dose modifications), pharmacokinetics of AZD5305, HRR/BRCA mutation status characterization, and exploratory companion diagnostic concordance analyses.
Burden on patient: Moderate. The regimen uses oral agents similar to standard practice in mCSPC, with routine imaging for progression, which aligns with standard care frequency in phase III settings. Added burden includes mandatory central HRR testing with archival or new FFPE tumor tissue and blood for ctDNA, periodic PRO questionnaires, and pharmacokinetic sampling for saruparib in the first 10 months. Safety labs and monitoring may be slightly more frequent early on. No routine invasive procedures beyond tissue provision are required, and treatment is outpatient, but long study duration with serial scans and visits contributes to cumulative time and travel demands.
Inclusion Criteria:
* Male ≥ 18 years of age.
* Histologically documented prostate adenocarcinoma which is de novo or recurrent and castration-sensitive. Participants with pathologic features of small cell, neuroendocrine, sarcomatoid, spindle cell, or signet cell histology are not eligible.
* Metastatic disease as documented by the investigator prior to randomisation, with clear evidence of ≥ 1 bone lesion and/or ≥ 1 soft tissue lesion that is suitable for repeated assessment with CT and/or MRI.
* Participant is receiving ADT with a GnRH analogue or has undergone bilateral orchiectomy starting ≥ 14 days and \< 4 months prior to randomisation.
* ECOG performance status of 0 or 1 with no deterioration over the 2 weeks prior to randomisation.
* Provision of FFPE tumour tissue sample and blood sample (for ctDNA).
* Confirmed HRRm status by central tumour tissue and/or ctDNA test is required to determine cohort eligibility.
* Adequate organ and bone marrow function as described in study protocol.
* Participants must not father children or donate sperm from signing ICF, during the study intervention and for 6 months after the last dose of study intervention.
* Participants must use a condom from signing ICF, during study intervention, and for 6 months after the last dose of study drug, with all sexual partners.
Exclusion Criteria:
* Participants with a history of MDS/AML or with features suggestive of MDS/AML (as determined by prior diagnostic investigation). In case there is no clinical MDS/AML suspicion, no specific screening for MDS/AML (by BM/bone biopsy) is required.
* Participants with any known predisposition to bleeding.
* Any history of persisting (\> 2 weeks) severe cytopenia.
* Refractory nausea and vomiting, chronic gastrointestinal diseases, inability to swallow the formulated product or previous significant bowel resection that would preclude adequate absorption of AZD5305 and/or the assigned NHA.
* History of another primary malignancy, with exceptions.
* Persistent toxicities (CTCAE Grade ≥ 2) caused by previous anticancer therapy.
* Spinal cord compression or brain metastases unless asymptomatic, stable, and not requiring steroids for at least 4 weeks prior to start of study intervention.
* Cardiac criteria, including history of arrhythmia and cardiovascular disease.
* Any prior anticancer pharmacotherapy or surgery for metastatic prostate cancer, with exceptions.
* Prior treatment within 14 days with blood product support or growth factor support.
* Participants who are unevaluable for both bone and soft tissue progression.
South Brisbane, 4101, Australia
No email / No phone
Status: Recruiting
Melbourne, 3000, Australia
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Status: Recruiting
Kurralta Park, 5037, Australia
No email / No phone
Status: Active, not recruiting
Hyde Park, 4812, Australia
No email / No phone
Status: Active, not recruiting
Darlinghurst, 2010, Australia
No email / No phone
Status: TERMINATED
Chermside, 4032, Australia
No email / No phone
Status: Recruiting
Randwick, 2031, Australia
No email / No phone
Status: Withdrawn
Krems, 3500, Austria
No email / No phone
Status: Recruiting
Vienna, 1020, Austria
No email / No phone
Status: Recruiting
Linz, 4020, Austria
No email / No phone
Status: Recruiting
Graz, 8036, Austria
No email / No phone
Status: Recruiting
Innsbruck, 6020, Austria
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Status: Recruiting
Vienna, 1090, Austria
No email / No phone
Status: Recruiting
Kortrijk, 8500, Belgium
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Status: Recruiting
Ghent, 9000, Belgium
No email / No phone
Status: Recruiting
Charleroi, 6060, Belgium
No email / No phone
Status: Withdrawn
Leuven, 3000, Belgium
No email / No phone
Status: Recruiting
São Paulo, 05652000, Brazil
No email / No phone
Status: Active, not recruiting
São Paulo, 01246-000, Brazil
No email / No phone
Status: Active, not recruiting
São Luís, 65060-645, Brazil
No email / No phone
Status: Withdrawn
Salvador, 41950-640, Brazil
No email / No phone
Status: Active, not recruiting
Rio de Janeiro, 22775-001, Brazil
No email / No phone
Status: Active, not recruiting
Porto Alegre, 91350-200, Brazil
No email / No phone
Status: Withdrawn
Porto Alegre, 90035-001, Brazil
No email / No phone
Status: Active, not recruiting
Pelotas, 96020-080, Brazil
No email / No phone
Status: Active, not recruiting
Curitiba, 80810-050, Brazil
No email / No phone
Status: Active, not recruiting
São Paulo, 01323-903, Brazil
No email / No phone
Status: Active, not recruiting
Calgary, Alberta, T2V 1P9, Canada
No email / No phone
Status: Recruiting
Calgary, Alberta, T2N 5G2, Canada
No email / No phone
Status: Recruiting
Edmonton, Alberta, T6G 1Z2, Canada
No email / No phone
Status: Withdrawn
Vancouver, British Columbia, V5Z 1H7, Canada
No email / No phone
Status: Recruiting
Kelowna, British Columbia, V1Y 5L3, Canada
No email / No phone
Status: Recruiting
Abbotsford, British Columbia, V2T 1X8, Canada
No email / No phone
Status: Recruiting
Winnipeg, Manitoba, R3E 0V9, Canada
No email / No phone
Status: Withdrawn
Halifax, Nova Scotia, B3H 2Y9, Canada
No email / No phone
Status: Withdrawn
Kingston, Ontario, K7L 5P9, Canada
No email / No phone
Status: Recruiting
London, Ontario, N6A 5W9, Canada
No email / No phone
Status: Withdrawn
Mississauga, Ontario, L5M 2N1, Canada
No email / No phone
Status: Recruiting
Newmarket, Ontario, L3Y 2P9, Canada
No email / No phone
Status: Recruiting
Ottawa, Ontario, K1H 8L6, Canada
No email / No phone
Status: Recruiting
Toronto, Ontario, M4N 3M5, Canada
No email / No phone
Status: Recruiting
Toronto, Ontario, M5G 2M9, Canada
No email / No phone
Status: Recruiting
Chicoutimi, Quebec, G7H 5H6, Canada
No email / No phone
Status: Recruiting
Greenfield Park, Quebec, J4V 2H1, Canada
No email / No phone
Status: Recruiting
Montreal, Quebec, H2X 3E4, Canada
No email / No phone
Status: Recruiting
Montreal, Quebec, H3T 1E2, Canada
No email / No phone
Status: Recruiting
Montreal, Quebec, H4A 3J1, Canada
No email / No phone
Status: Recruiting
Québec, Quebec, G1J 1Z4, Canada
No email / No phone
Status: Recruiting
Saskatoon, Saskatchewan, S7N 4H4, Canada
No email / No phone
Status: Recruiting
Concepción, 4070196, Chile
No email / No phone
Status: Active, not recruiting
La Serena, 1720430, Chile
No email / No phone
Status: Active, not recruiting
Santiago, 7500787, Chile
No email / No phone
Status: Active, not recruiting
Santiago, 7500921, Chile
No email / No phone
Status: Withdrawn
Santiago, 7520349, Chile
No email / No phone
Status: Active, not recruiting
Santiago, 8241479, Chile
No email / No phone
Status: Active, not recruiting
Santiago, 8330032, Chile
No email / No phone
Status: Active, not recruiting
Temuco, 4781156, Chile
No email / No phone
Status: Active, not recruiting
Viña del Mar, 2540488, Chile
No email / No phone
Status: Active, not recruiting
Xi'an, 710061, China
No email / No phone
Status: Active, not recruiting
Wenzhou, 325000, China
No email / No phone
Status: Active, not recruiting
Weifang, 261000, China
No email / No phone
Status: Withdrawn
Tianjin, 300211, China
No email / No phone
Status: Active, not recruiting
Taiyuan, 030000, China
No email / No phone
Status: Active, not recruiting
Suining, 629000, China
No email / No phone
Status: Active, not recruiting
Shenyang, 110004, China
No email / No phone
Status: Active, not recruiting
Shenyang, 110001, China
No email / No phone
Status: Active, not recruiting
Shenyang, 110001, China
No email / No phone
Status: Withdrawn
Shanghai, 200080, China
No email / No phone
Status: Active, not recruiting
Shanghai, 200002, China
No email / No phone
Status: Active, not recruiting
Shandong, China
No email / No phone
Status: Active, not recruiting
Ningbo, 315010, China
No email / No phone
Status: Active, not recruiting
Nantong, 226361, China
No email / No phone
Status: Active, not recruiting
Nanjing, 2100008, China
No email / No phone
Status: Active, not recruiting
Nanchang, 330029, China
No email / No phone
Status: Active, not recruiting
Nanchang, 330000, China
No email / No phone
Status: Active, not recruiting
Lanzhou, 730030, China
No email / No phone
Status: Active, not recruiting
Jinan, 250021, China
No email / No phone
Status: Active, not recruiting
Jiaxing, 314001, China
No email / No phone
Status: Active, not recruiting
Harbin, 150081, China
No email / No phone
Status: Completed
Hangzhou, 310022, China
No email / No phone
Status: Active, not recruiting
Hangzhou, 310009, China
No email / No phone
Status: Active, not recruiting
Guilin, 541000, China
No email / No phone
Status: Active, not recruiting
Guangzhou, 510515, China
No email / No phone
Status: Withdrawn
Guangzhou, 510180, China
No email / No phone
Status: Active, not recruiting
Dongguan, 523009, China
No email / No phone
Status: Active, not recruiting
Chongqing, 400038, China
No email / No phone
Status: Active, not recruiting
Chongqing, 400030, China
No email / No phone
Status: Active, not recruiting
Chengdu, 610041, China
No email / No phone
Status: Active, not recruiting
Changsha, 410013, China
No email / No phone
Status: Active, not recruiting
Changchun, 130021, China
No email / No phone
Status: Active, not recruiting
Beijing, CN-100730, China
No email / No phone
Status: Active, not recruiting
Beijing, 100142, China
No email / No phone
Status: Active, not recruiting
Beijing, 100050, China
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Status: Completed
Beijing, 100034, China
No email / No phone
Status: Active, not recruiting
Beijing, 100021, China
No email / No phone
Status: Active, not recruiting
Zhengzhou, 450008, China
No email / No phone
Status: Active, not recruiting
Yantai, 264000, China
No email / No phone
Status: Active, not recruiting
Wuhan, 430079, China
No email / No phone
Status: Completed
Tampere, 33521, Finland
No email / No phone
Status: Withdrawn
Helsinki, 00290, Finland
No email / No phone
Status: Withdrawn
Turku, 20520, Finland
No email / No phone
Status: Withdrawn
Strasbourg, 67200, France
No email / No phone
Status: Active, not recruiting
Rennes, 35033, France
No email / No phone
Status: Active, not recruiting
Quimper, 29107, France
No email / No phone
Status: Active, not recruiting
Poitiers, 86021, France
No email / No phone
Status: Recruiting
Pierre-Bénite, 69495, France
No email / No phone
Status: Active, not recruiting
Paris, 75679, France
No email / No phone
Status: Recruiting
Nîmes, 30029, France
No email / No phone
Status: Active, not recruiting
Nice, 06100, France
No email / No phone
Status: Recruiting
Montpellier, 34298, France
No email / No phone
Status: Recruiting
Lyon, 69373, France
No email / No phone
Status: Recruiting
Créteil, 94000, France
No email / No phone
Status: Active, not recruiting
Clermont-Ferrand, 63011, France
No email / No phone
Status: Recruiting
Caen, 41076, France
No email / No phone
Status: Active, not recruiting
Angers, 49055, France
No email / No phone
Status: Active, not recruiting
Bayonne, 64109, France
No email / No phone
Status: Active, not recruiting
Bordeaux, 33000, France
No email / No phone
Status: Recruiting
Vandœuvre-lès-Nancy, 54519, France
No email / No phone
Status: Active, not recruiting
Tours, 37000, France
No email / No phone
Status: Recruiting
Cologne, 50968, Germany
No email / No phone
Status: Active, not recruiting
Ulm, 89081, Germany
No email / No phone
Status: Active, not recruiting
Tübingen, 72076, Germany
No email / No phone
Status: Recruiting
Trier, 54292, Germany
No email / No phone
Status: Active, not recruiting
Stuttgart, 70176, Germany
No email / No phone
Status: Withdrawn
Regensburg, 93053, Germany
No email / No phone
Status: Recruiting
Oldenburg, 26133, Germany
No email / No phone
Status: Withdrawn
Nürtingen, 72622, Germany
No email / No phone
Status: Recruiting
Münster, 48149, Germany
No email / No phone
Status: Recruiting
München, 81675, Germany
No email / No phone
Status: Recruiting
Mettmann, 40822, Germany
No email / No phone
Status: Active, not recruiting
Marburg, 35043, Germany
No email / No phone
Status: Active, not recruiting
Mannheim, 68167, Germany
No email / No phone
Status: Active, not recruiting
Magdeburg, 39120, Germany
No email / No phone
Status: Recruiting
Homburg, 66421, Germany
No email / No phone
Status: Active, not recruiting
Herne, 44625, Germany
No email / No phone
Status: Active, not recruiting
Heidelberg, 69120, Germany
No email / No phone
Status: Recruiting
Hamburg, 20246, Germany
No email / No phone
Status: Recruiting
Göttingen, 37075, Germany
No email / No phone
Status: Withdrawn
Freiburg im Breisgau, 79106, Germany
No email / No phone
Status: Recruiting
Frankfurt am Main, 60590, Germany
No email / No phone
Status: Active, not recruiting
Frankfurt, 60488, Germany
No email / No phone
Status: Active, not recruiting
Erlangen, 91054, Germany
No email / No phone
Status: Recruiting
Duisburg, 47169, Germany
No email / No phone
Status: Active, not recruiting
Dresden, 01307, Germany
No email / No phone
Status: Active, not recruiting
Berlin, 10117, Germany
No email / No phone
Status: Active, not recruiting
Braunschweig, 38126, Germany
No email / No phone
Status: Active, not recruiting
Bonn, 53113, Germany
No email / No phone
Status: Withdrawn
Bergisch Gladbach, 51465, Germany
No email / No phone
Status: Active, not recruiting
Budapest, 1145, Hungary
No email / No phone
Status: Active, not recruiting
Debrecen, 4032, Hungary
No email / No phone
Status: Active, not recruiting
Győr, 9024, Hungary
No email / No phone
Status: Withdrawn
Miskolc, 3526, Hungary
No email / No phone
Status: Active, not recruiting
Nyíregyháza, 4400, Hungary
No email / No phone
Status: Withdrawn
Szeged, 6725, Hungary
No email / No phone
Status: Active, not recruiting
Szekszárd, 7100, Hungary
No email / No phone
Status: Recruiting
Budapest, 1122, Hungary
No email / No phone
Status: Active, not recruiting
Budapest, 1062, Hungary
No email / No phone
Status: Withdrawn
Budapest, 1125, Hungary
No email / No phone
Status: Withdrawn
Delhi, 110029, India
No email / No phone
Status: Withdrawn
Jaipur, 302022, India
No email / No phone
Status: Withdrawn
Kanpur, 208005, India
No email / No phone
Status: Active, not recruiting
Kolkata, 700099, India
No email / No phone
Status: Recruiting
Kolkata, 700160, India
No email / No phone
Status: Withdrawn
Mohali, 160055, India
No email / No phone
Status: Withdrawn
Nagpur, 440001, India
No email / No phone
Status: Recruiting
New Delhi, 110085, India
No email / No phone
Status: Active, not recruiting
New Delhi, 11029, India
No email / No phone
Status: Recruiting
Pune, 411004, India
No email / No phone
Status: Active, not recruiting
Surat, 395002, India
No email / No phone
Status: Withdrawn
Vadodara, 391760, India
No email / No phone
Status: Recruiting
Varanasi, 221005, India
No email / No phone
Status: Recruiting
Bangalore, 560027, India
No email / No phone
Status: Recruiting
Calicut, 673601, India
No email / No phone
Status: Recruiting
Hyderabad, 500032, India
No email / No phone
Status: Withdrawn
Meldola, 47014, Italy
No email / No phone
Status: Active, not recruiting
Trento, 38100, Italy
No email / No phone
Status: Active, not recruiting
Milan, 20132, Italy
No email / No phone
Status: Active, not recruiting
Milan, 20133, Italy
No email / No phone
Status: Recruiting
Terni, 05100, Italy
No email / No phone
Status: Active, not recruiting
Napoli, 80131, Italy
No email / No phone
Status: Active, not recruiting
Padua, 35128, Italy
No email / No phone
Status: Recruiting
Rome, 00168, Italy
No email / No phone
Status: Active, not recruiting
Rozzano, 20089, Italy
No email / No phone
Status: Recruiting
Bari, 70124, Italy
No email / No phone
Status: Active, not recruiting
Genoa, 16132, Italy
No email / No phone
Status: Recruiting
Sagamihara-shi, 252-0375, Japan
No email / No phone
Status: Recruiting
Chiba, 260-8717, Japan
No email / No phone
Status: Recruiting
Fukuoka, 811-1347, Japan
No email / No phone
Status: Recruiting
Fukuoka, 812-8582, Japan
No email / No phone
Status: Recruiting
Hirakata-shi, 573-1191, Japan
No email / No phone
Status: Recruiting
Hirosaki-shi, 036-8563, Japan
No email / No phone
Status: Recruiting
Kanazawa, 920-8641, Japan
No email / No phone
Status: Recruiting
Kashihara-shi, 634-8522, Japan
No email / No phone
Status: Recruiting
Kawagoe-shi, 350-8550, Japan
No email / No phone
Status: Recruiting
Kisarazu-shi, 292-8535, Japan
No email / No phone
Status: Recruiting
Kita-gun, 761-0793, Japan
No email / No phone
Status: Recruiting
Kobe, 650-0047, Japan
No email / No phone
Status: Recruiting
Kumamoto, 860-0008, Japan
No email / No phone
Status: Recruiting
Kyoto, 606-8507, Japan
No email / No phone
Status: Recruiting
Maebashi, 371-8811, Japan
No email / No phone
Status: Recruiting
Nagano, 381-8551, Japan
No email / No phone
Status: Recruiting
Nagasaki, 852-8501, Japan
No email / No phone
Status: Recruiting
Nagoya, 466-8560, Japan
No email / No phone
Status: Recruiting
Nagoya, 466-8650, Japan
No email / No phone
Status: Recruiting
Osaka, 541-8567, Japan
No email / No phone
Status: Recruiting
Osakasayama-shi, 589-8511, Japan
No email / No phone
Status: Recruiting
Sakura-shi, 285-8741, Japan
No email / No phone
Status: Recruiting
Sapporo, 060-8638, Japan
No email / No phone
Status: Recruiting
Shiwa-gun, 028-3695, Japan
No email / No phone
Status: Recruiting
Suita-shi, 565-0871, Japan
No email / No phone
Status: Recruiting
Tsu, 514-8507, Japan
No email / No phone
Status: Recruiting
Yokohama, 232-0024, Japan
No email / No phone
Status: Recruiting
Yufu-shi, 879-5593, Japan
No email / No phone
Status: Recruiting
Johor Bahru, 81100, Malaysia
No email / No phone
Status: Recruiting
Kota Kinabalu, 88996, Malaysia
No email / No phone
Status: Recruiting
Kuala Lumpur, 50586, Malaysia
No email / No phone
Status: Recruiting
Kuala Lumpur, 59100, Malaysia
No email / No phone
Status: Recruiting
Kuching, 93586, Malaysia
No email / No phone
Status: Recruiting
George Town, 10450, Malaysia
No email / No phone
Status: Recruiting
Hilversum, 1213 XZ, Netherlands
No email / No phone
Status: Recruiting
Nijmegen, 6525 GA, Netherlands
No email / No phone
Status: Recruiting
Amsterdam, 1066 CX, Netherlands
No email / No phone
Status: Recruiting
Bellavista, CALLAO 2, Peru
No email / No phone
Status: Recruiting
Lima, 15036, Peru
No email / No phone
Status: Active, not recruiting
Lima, 15082, Peru
No email / No phone
Status: Recruiting
Lima, 15102, Peru
No email / No phone
Status: Active, not recruiting
Lima, 34, Peru
No email / No phone
Status: Active, not recruiting
Lima, LIMA 29, Peru
No email / No phone
Status: Active, not recruiting
Arequipa, AREQUIPA01, Peru
No email / No phone
Status: Recruiting
Bydgoszcz, 85-796, Poland
No email / No phone
Status: Active, not recruiting
Poznan, 61-731, Poland
No email / No phone
Status: Active, not recruiting
Rzeszów, 35-001, Poland
No email / No phone
Status: Active, not recruiting
Szczecin, 71-730, Poland
No email / No phone
Status: Withdrawn
Warsaw, 04-073, Poland
No email / No phone
Status: Active, not recruiting
Wroclaw, 53-329, Poland
No email / No phone
Status: Active, not recruiting
Żory, 44-240, Poland
No email / No phone
Status: Withdrawn
Koszalin, 75-581, Poland
No email / No phone
Status: Active, not recruiting
San Juan, 00927, Puerto Rico
No email / No phone
Status: Withdrawn
Seongnam-si, 13620, South Korea
No email / No phone
Status: Active, not recruiting
Daejeon, 35015, South Korea
No email / No phone
Status: Active, not recruiting
Seoul, 03080, South Korea
No email / No phone
Status: Active, not recruiting
Seoul, 03722, South Korea
No email / No phone
Status: Active, not recruiting
Seoul, 05505, South Korea
No email / No phone
Status: Active, not recruiting
Seoul, 06351, South Korea
No email / No phone
Status: Active, not recruiting
Seoul, 06591, South Korea
No email / No phone
Status: Active, not recruiting
Suwon, 16247, South Korea
No email / No phone
Status: Active, not recruiting
Lugo, 27003, Spain
No email / No phone
Status: Recruiting
Barcelona, 08035, Spain
No email / No phone
Status: Recruiting
Córdoba, 14004, Spain
No email / No phone
Status: Recruiting
L'Hospitalet de Llobregat, 08908, Spain
No email / No phone
Status: Recruiting
Madrid, 28034, Spain
No email / No phone
Status: Recruiting
Valencia, 46014, Spain
No email / No phone
Status: Recruiting
Madrid, 28040, Spain
No email / No phone
Status: Recruiting
Madrid, 28041, Spain
No email / No phone
Status: Recruiting
Sabadell, 08208, Spain
No email / No phone
Status: Recruiting
Stockholm, 118 83, Sweden
No email / No phone
Status: Withdrawn
Solna, 171 64, Sweden
No email / No phone
Status: Withdrawn
Malmo, 20502, Sweden
No email / No phone
Status: Withdrawn
Gothenburg, 413 45, Sweden
No email / No phone
Status: Withdrawn
Kaohsiung City, 833, Taiwan
No email / No phone
Status: Recruiting
Yung Kang City, 71044, Taiwan
No email / No phone
Status: Recruiting
Taoyuan District, 333, Taiwan
No email / No phone
Status: Recruiting
Taichung, 43503, Taiwan
No email / No phone
Status: Recruiting
Taichung, 40447, Taiwan
No email / No phone
Status: Recruiting
Kaohsiung City, 80756, Taiwan
No email / No phone
Status: Recruiting
Bangkok, 10210, Thailand
No email / No phone
Status: Active, not recruiting
Songkhla, 90110, Thailand
No email / No phone
Status: Active, not recruiting
Khlong Luang, 12120, Thailand
No email / No phone
Status: Active, not recruiting
Chiang Mai, 50200, Thailand
No email / No phone
Status: Active, not recruiting
Bangkok, 10700, Thailand
No email / No phone
Status: Active, not recruiting
Bangkok, 10330, Thailand
No email / No phone
Status: Active, not recruiting
Karşıyaka, 35575, Turkey (Türkiye)
No email / No phone
Status: Recruiting
Istanbul, 34722, Turkey (Türkiye)
No email / No phone
Status: Recruiting
Fatih-Istanbul, 34098, Turkey (Türkiye)
No email / No phone
Status: Recruiting
Bornova-Izmir, 35100, Turkey (Türkiye)
No email / No phone
Status: Recruiting
Ankara, 06590, Turkey (Türkiye)
No email / No phone
Status: Recruiting
Ankara, 06340, Turkey (Türkiye)
No email / No phone
Status: Recruiting
Aberdeen, AB25 2ZN, United Kingdom
No email / No phone
Status: Recruiting
Manchester, M20 4BX, United Kingdom
No email / No phone
Status: Recruiting
Birmingham, B15 2GW, United Kingdom
No email / No phone
Status: Recruiting
Cambridge, CB2 0QQ, United Kingdom
No email / No phone
Status: Recruiting
Glasgow, G12 0YN, United Kingdom
No email / No phone
Status: Recruiting
Guildford, GU2 7XX, United Kingdom
No email / No phone
Status: Recruiting
London, EC1A 7BE, United Kingdom
No email / No phone
Status: Recruiting
London, W6 8RF, United Kingdom
No email / No phone
Status: Recruiting
Truro, TR1 3LJ, United Kingdom
No email / No phone
Status: Recruiting
Swansea, SA2 8QA, United Kingdom
No email / No phone
Status: Withdrawn
Preston, PR2 9HT, United Kingdom
No email / No phone
Status: Recruiting
Plymouth, PL6 8DH, United Kingdom
No email / No phone
Status: Recruiting
Oxford, OX3 7LE, United Kingdom
No email / No phone
Status: Recruiting
Newcastle upon Tyne, NE7 7AF, United Kingdom
No email / No phone
Status: Recruiting
Phoenix, Arizona, 85054, United States
No email / No phone
Status: Recruiting
Chandler, Arizona, 85224, United States
No email / No phone
Status: Recruiting
Gilbert, Arizona, 85234, United States
No email / No phone
Status: Recruiting
Tucson, Arizona, 85741, United States
No email / No phone
Status: Recruiting
Little Rock, Arkansas, 72205, United States
No email / No phone
Status: Recruiting
Springdale, Arkansas, 72762, United States
No email / No phone
Status: Recruiting
Santa Monica, California, 90404, United States
No email / No phone
Status: Recruiting
Bakersfield, California, 93301, United States
No email / No phone
Status: Recruiting
Fountain Valley, California, 92708, United States
No email / No phone
Status: Recruiting
Fullerton, California, 92835, United States
No email / No phone
Status: Recruiting
Los Angeles, California, 90073, United States
No email / No phone
Status: Recruiting
Los Angeles, California, 90095, United States
No email / No phone
Status: Withdrawn
Montebello, California, 90640, United States
No email / No phone
Status: Recruiting
Pasadena, California, 91101, United States
No email / No phone
Status: Withdrawn
Pomona, California, 91767, United States
No email / No phone
Status: Withdrawn
Sacramento, California, 95816, United States
No email / No phone
Status: Withdrawn
San Diego, California, 92123, United States
No email / No phone
Status: Withdrawn
San Francisco, California, 94115, United States
No email / No phone
Status: Recruiting
Santa Barbara, California, 93105, United States
No email / No phone
Status: Recruiting
Santa Rosa, California, 95403, United States
No email / No phone
Status: Recruiting
Golden, Colorado, 80401, United States
No email / No phone
Status: Recruiting
Lakewood, Colorado, 80228, United States
No email / No phone
Status: Recruiting
Norwich, Connecticut, 06360, United States
No email / No phone
Status: Withdrawn
New Haven, Connecticut, 06510, United States
No email / No phone
Status: Recruiting
Newark, Delaware, 19713, United States
No email / No phone
Status: Withdrawn
Tampa, Florida, 33612, United States
No email / No phone
Status: Withdrawn
St. Petersburg, Florida, 33705, United States
No email / No phone
Status: Withdrawn
Palm Bay, Florida, 32909, United States
No email / No phone
Status: Withdrawn
Jacksonville, Florida, 32224, United States
No email / No phone
Status: Withdrawn
Jacksonville, Florida, 32209, United States
No email / No phone
Status: Withdrawn
Atlanta, Georgia, 30318, United States
No email / No phone
Status: Recruiting
Lake Barrington, Illinois, 60010, United States
No email / No phone
Status: Recruiting
Glenview, Illinois, 60026, United States
No email / No phone
Status: Recruiting
Indianapolis, Indiana, 46202, United States
No email / No phone
Status: Recruiting
Fort Wayne, Indiana, 46804, United States
No email / No phone
Status: Recruiting
Des Moines, Iowa, 50309, United States
No email / No phone
Status: Withdrawn
Westwood, Kansas, 66205, United States
No email / No phone
Status: Recruiting
Wichita, Kansas, 67226, United States
No email / No phone
Status: Withdrawn
Lexington, Kentucky, 40503, United States
No email / No phone
Status: Withdrawn
Louisville, Kentucky, 40202, United States
No email / No phone
Status: Withdrawn
Shreveport, Louisiana, 71103, United States
No email / No phone
Status: Recruiting
Scarborough, Maine, 04074, United States
No email / No phone
Status: Recruiting
Towson, Maryland, 21204, United States
No email / No phone
Status: Recruiting
Baltimore, Maryland, 21201, United States
No email / No phone
Status: Recruiting
Baltimore, Maryland, 21287, United States
No email / No phone
Status: Recruiting
Bethesda, Maryland, 20817, United States
No email / No phone
Status: Recruiting
Upper Marlboro, Maryland, 20774, United States
No email / No phone
Status: Recruiting
Troy, Michigan, 48084, United States
No email / No phone
Status: Recruiting
Grand Rapids, Michigan, 49503, United States
No email / No phone
Status: Recruiting
Rochester, Minnesota, 55905, United States
No email / No phone
Status: Recruiting
Columbia, Missouri, 65212, United States
No email / No phone
Status: Withdrawn
Billings, Montana, 59102, United States
No email / No phone
Status: Withdrawn
Bozeman, Montana, 59715, United States
No email / No phone
Status: Recruiting
Las Vegas, Nevada, 89102, United States
No email / No phone
Status: Recruiting
Las Vegas, Nevada, 89148, United States
No email / No phone
Status: Recruiting
Voorhees Township, New Jersey, 08043, United States
No email / No phone
Status: Withdrawn
East Brunswick, New Jersey, 08816, United States
No email / No phone
Status: Withdrawn
Belleville, New Jersey, 07109, United States
No email / No phone
Status: Withdrawn
Brick, New Jersey, 08724, United States
No email / No phone
Status: Withdrawn
Camden, New Jersey, 08103, United States
No email / No phone
Status: Recruiting
Albuquerque, New Mexico, 87110, United States
No email / No phone
Status: Withdrawn
Albuquerque, New Mexico, 87109, United States
No email / No phone
Status: Recruiting
Rio Rancho, New Mexico, 87124, United States
No email / No phone
Status: Withdrawn
Syracuse, New York, 13210, United States
No email / No phone
Status: Recruiting
Albany, New York, 12206, United States
No email / No phone
Status: Withdrawn
East Syracuse, New York, 13057, United States
No email / No phone
Status: Recruiting
New Hyde Park, New York, 11042, United States
No email / No phone
Status: Recruiting
New York, New York, 10028, United States
No email / No phone
Status: Withdrawn
New York, New York, 10029, United States
No email / No phone
Status: Recruiting
Shirley, New York, 11967, United States
No email / No phone
Status: Withdrawn
The Bronx, New York, 10469, United States
No email / No phone
Status: Withdrawn
Durham, North Carolina, 27710, United States
No email / No phone
Status: Recruiting
Fayetteville, North Carolina, 28303, United States
No email / No phone
Status: Withdrawn
Cincinnati, Ohio, 45212, United States
No email / No phone
Status: Recruiting
Cincinnati, Ohio, 45219, United States
No email / No phone
Status: Recruiting
Cleveland, Ohio, 44109, United States
No email / No phone
Status: Withdrawn
Cleveland, Ohio, 44111, United States
No email / No phone
Status: Recruiting
Cleveland, Ohio, 44124, United States
No email / No phone
Status: Recruiting
Cleveland, Ohio, 44130, United States
No email / No phone
Status: Withdrawn
Columbus, Ohio, 43210, United States
No email / No phone
Status: Recruiting
Independence, Ohio, 44131, United States
No email / No phone
Status: Withdrawn
Wooster, Ohio, 44691, United States
No email / No phone
Status: Withdrawn
Portland, Oregon, 97227, United States
No email / No phone
Status: Recruiting
Portland, Oregon, 97239, United States
No email / No phone
Status: Withdrawn
Florence, Oregon, 97439, United States
No email / No phone
Status: Withdrawn
Pittsburgh, Pennsylvania, 15212, United States
No email / No phone
Status: Recruiting
Pittsburgh, Pennsylvania, 15213, United States
No email / No phone
Status: Withdrawn
York, Pennsylvania, 17403, United States
No email / No phone
Status: Withdrawn
Bala-Cynwyd, Pennsylvania, 19004-1017, United States
No email / No phone
Status: Recruiting
Philadelphia, Pennsylvania, 19104, United States
No email / No phone
Status: Recruiting
Providence, Rhode Island, 02903, United States
No email / No phone
Status: Recruiting
North Charleston, South Carolina, 29406, United States
No email / No phone
Status: Recruiting
Myrtle Beach, South Carolina, 29572, United States
No email / No phone
Status: Recruiting
Sioux Falls, South Dakota, 57105, United States
No email / No phone
Status: Recruiting
Nashville, Tennessee, 37203, United States
No email / No phone
Status: Recruiting
Germantown, Tennessee, 38138, United States
No email / No phone
Status: Recruiting
Wichita Falls, Texas, 76310, United States
No email / No phone
Status: Recruiting
Dallas, Texas, 75231, United States
No email / No phone
Status: Recruiting
Dallas, Texas, 75246, United States
No email / No phone
Status: Withdrawn
Denton, Texas, 76201, United States
No email / No phone
Status: Withdrawn
Flower Mound, Texas, 75028, United States
No email / No phone
Status: Withdrawn
Grapevine, Texas, 76051, United States
No email / No phone
Status: Withdrawn
Houston, Texas, 77025, United States
No email / No phone
Status: Recruiting
Houston, Texas, 77027, United States
No email / No phone
Status: Withdrawn
Houston, Texas, 77030, United States
No email / No phone
Status: Withdrawn
Plano, Texas, 75093, United States
No email / No phone
Status: Withdrawn
San Antonio, Texas, 78217, United States
No email / No phone
Status: Withdrawn
San Antonio, Texas, 78229, United States
No email / No phone
Status: Recruiting
Sugar Land, Texas, 77479, United States
No email / No phone
Status: Recruiting
Tyler, Texas, 75702, United States
No email / No phone
Status: Recruiting
Salt Lake City, Utah, 84106, United States
No email / No phone
Status: Recruiting
Salt Lake City, Utah, 84132, United States
No email / No phone
Status: Recruiting
St. George, Utah, 84790, United States
No email / No phone
Status: Recruiting
Winchester, Virginia, 22601, United States
No email / No phone
Status: Withdrawn
Fairfax, Virginia, 22031, United States
No email / No phone
Status: Recruiting
Spokane Valley, Washington, 99216, United States
No email / No phone
Status: Withdrawn
Spokane, Washington, 99202, United States
No email / No phone
Status: Recruiting
Tacoma, Washington, 98405, United States
No email / No phone
Status: Recruiting