A Randomized, 2-cohort, Double-blind, Placebo-controlled, Phase III Study of Saruparib (AZD5305) in Combination With Physician's Choice New Hormonal Agents in Patients With HRRm and Non-HRRm Metastatic Castration-Sensitive Prostate Cancer (EvoPAR-Prostate01)

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Investigational drug late phase More information Active drug More information Moderate burden on patient More information

Trial Details

Sponsor: AstraZeneca (industry)

Phase: 3

Start date: Nov. 21, 2023

Planned enrollment: 1800

Trial ID: NCT06120491
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More trial details at ClinicalTrials.gov More info

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Goal: To determine whether adding the PARP1-selective inhibitor saruparib (AZD5305) to a physician’s choice of next-generation hormonal agent improves radiographic progression-free survival versus placebo plus the same hormonal backbone in men with metastatic castration-sensitive prostate cancer (mCSPC), with planned evaluation in HRR-mutated (HRRm) and non-HRRm cohorts.

Patients: Adult men (≥18 years) with histologically confirmed metastatic castration-sensitive prostate adenocarcinoma, ECOG 0–1, on ADT or post-orchiectomy, with at least one evaluable bone or soft-tissue lesion. Key exclusions include small cell/neuroendocrine variants, prior systemic therapy for metastatic disease (with protocol-defined exceptions), significant hematologic disorders (e.g., MDS/AML, severe cytopenias), significant cardiovascular disease or arrhythmias, symptomatic/unstable CNS disease or spinal cord compression, uncontrolled GI conditions affecting absorption, and persistence of ≥ grade 2 toxicities from prior therapy. Central testing assigns patients to HRRm or non-HRRm cohorts.

Design: Global, double-blind, placebo-controlled, randomized phase III trial with two parallel cohorts (approximately 550 HRRm and 1250 non-HRRm). Patients are randomized 1:1 to saruparib plus new hormonal agent (NHA) versus placebo plus NHA, treated until progression or discontinuation. Survival follow-up continues to study end. Safety oversight by an independent data monitoring committee.

Treatments: Experimental arm: saruparib (AZD5305) combined with physician’s choice NHA (abiraterone, darolutamide, or enzalutamide). Control arm: placebo plus the same physician’s choice NHA. Saruparib is a next-generation, PARP1-selective inhibitor designed to retain antitumor efficacy while reducing hematologic toxicity associated with PARP2 inhibition. It traps PARP1 on DNA, inducing replication stress and genomic instability in tumors with homologous recombination repair deficiency. Early-phase PETRA data in HER2-negative breast cancer showed objective responses at the recommended phase 2 dose with a favorable hematologic safety profile compared with first-generation PARP inhibitors, supporting further evaluation in prostate cancer. Abiraterone, enzalutamide, and darolutamide are established androgen signaling–targeted therapies used as standard of care in mCSPC.

Outcomes: Primary: radiographic progression-free survival per RECIST 1.1 (soft tissue) and/or PCWG3 (bone), or death. Key secondary endpoints include overall survival, PFS2, time to first subsequent therapy or death, symptomatic skeletal event–free survival, time to first castration-resistant event, time to pain progression, and patient-reported outcomes including time to deterioration in urinary symptoms, fatigue, and physical function, as well as health-related quality of life measures. Additional endpoints include PSA response metrics, safety and tolerability (TEAEs/SAEs and dose modifications), pharmacokinetics of AZD5305, HRR/BRCA mutation status characterization, and exploratory companion diagnostic concordance analyses.

Burden on patient: Moderate. The regimen uses oral agents similar to standard practice in mCSPC, with routine imaging for progression, which aligns with standard care frequency in phase III settings. Added burden includes mandatory central HRR testing with archival or new FFPE tumor tissue and blood for ctDNA, periodic PRO questionnaires, and pharmacokinetic sampling for saruparib in the first 10 months. Safety labs and monitoring may be slightly more frequent early on. No routine invasive procedures beyond tissue provision are required, and treatment is outpatient, but long study duration with serial scans and visits contributes to cumulative time and travel demands.

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South Brisbane, 4101, Australia

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Melbourne, 3000, Australia

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Kurralta Park, 5037, Australia

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Hyde Park, 4812, Australia

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Darlinghurst, 2010, Australia

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Chermside, 4032, Australia

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Randwick, 2031, Australia

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Krems, 3500, Austria

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Vienna, 1020, Austria

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Linz, 4020, Austria

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Graz, 8036, Austria

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Innsbruck, 6020, Austria

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Vienna, 1090, Austria

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Kortrijk, 8500, Belgium

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Ghent, 9000, Belgium

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Charleroi, 6060, Belgium

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Leuven, 3000, Belgium

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São Paulo, 05652000, Brazil

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São Paulo, 01246-000, Brazil

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São Luís, 65060-645, Brazil

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Salvador, 41950-640, Brazil

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Rio de Janeiro, 22775-001, Brazil

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Porto Alegre, 91350-200, Brazil

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Porto Alegre, 90035-001, Brazil

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Pelotas, 96020-080, Brazil

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Curitiba, 80810-050, Brazil

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São Paulo, 01323-903, Brazil

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Calgary, Alberta, T2V 1P9, Canada

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Calgary, Alberta, T2N 5G2, Canada

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Edmonton, Alberta, T6G 1Z2, Canada

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Vancouver, British Columbia, V5Z 1H7, Canada

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Kelowna, British Columbia, V1Y 5L3, Canada

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Abbotsford, British Columbia, V2T 1X8, Canada

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Winnipeg, Manitoba, R3E 0V9, Canada

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Halifax, Nova Scotia, B3H 2Y9, Canada

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Kingston, Ontario, K7L 5P9, Canada

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London, Ontario, N6A 5W9, Canada

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Mississauga, Ontario, L5M 2N1, Canada

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Newmarket, Ontario, L3Y 2P9, Canada

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Ottawa, Ontario, K1H 8L6, Canada

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Toronto, Ontario, M4N 3M5, Canada

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Chicoutimi, Quebec, G7H 5H6, Canada

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Greenfield Park, Quebec, J4V 2H1, Canada

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Saskatoon, Saskatchewan, S7N 4H4, Canada

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Concepción, 4070196, Chile

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La Serena, 1720430, Chile

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Santiago, 7500787, Chile

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Santiago, 7500921, Chile

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Santiago, 7520349, Chile

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Santiago, 8241479, Chile

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Santiago, 8330032, Chile

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Temuco, 4781156, Chile

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Viña del Mar, 2540488, Chile

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Xi'an, 710061, China

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Wenzhou, 325000, China

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Weifang, 261000, China

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Tianjin, 300211, China

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Taiyuan, 030000, China

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Suining, 629000, China

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Shenyang, 110004, China

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Shenyang, 110001, China

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Shenyang, 110001, China

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Shanghai, 200080, China

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Shandong, China

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Ningbo, 315010, China

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Nantong, 226361, China

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Nanjing, 2100008, China

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Nanchang, 330029, China

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Nanchang, 330000, China

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Lanzhou, 730030, China

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Jinan, 250021, China

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Jiaxing, 314001, China

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Harbin, 150081, China

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Hangzhou, 310022, China

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Hangzhou, 310009, China

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Guilin, 541000, China

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Guangzhou, 510515, China

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Guangzhou, 510180, China

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Dongguan, 523009, China

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Chongqing, 400038, China

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Chongqing, 400030, China

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Chengdu, 610041, China

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Changsha, 410013, China

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Changchun, 130021, China

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Beijing, CN-100730, China

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Beijing, 100142, China

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Beijing, 100050, China

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Beijing, 100034, China

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Beijing, 100021, China

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Zhengzhou, 450008, China

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Yantai, 264000, China

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Wuhan, 430079, China

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Tampere, 33521, Finland

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Helsinki, 00290, Finland

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Turku, 20520, Finland

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Strasbourg, 67200, France

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Rennes, 35033, France

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Quimper, 29107, France

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Poitiers, 86021, France

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Pierre-Bénite, 69495, France

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Paris, 75679, France

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Nîmes, 30029, France

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Nice, 06100, France

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Montpellier, 34298, France

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Lyon, 69373, France

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Créteil, 94000, France

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Clermont-Ferrand, 63011, France

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Caen, 41076, France

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Angers, 49055, France

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Bayonne, 64109, France

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Bordeaux, 33000, France

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Vandœuvre-lès-Nancy, 54519, France

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Tours, 37000, France

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Cologne, 50968, Germany

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Ulm, 89081, Germany

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Tübingen, 72076, Germany

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Trier, 54292, Germany

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Stuttgart, 70176, Germany

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Regensburg, 93053, Germany

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Oldenburg, 26133, Germany

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Nürtingen, 72622, Germany

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Münster, 48149, Germany

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München, 81675, Germany

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Mettmann, 40822, Germany

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Marburg, 35043, Germany

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Mannheim, 68167, Germany

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Magdeburg, 39120, Germany

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Homburg, 66421, Germany

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Herne, 44625, Germany

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Heidelberg, 69120, Germany

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Hamburg, 20246, Germany

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Göttingen, 37075, Germany

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Freiburg im Breisgau, 79106, Germany

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Frankfurt am Main, 60590, Germany

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Frankfurt, 60488, Germany

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Erlangen, 91054, Germany

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Duisburg, 47169, Germany

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Dresden, 01307, Germany

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Berlin, 10117, Germany

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Braunschweig, 38126, Germany

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Bonn, 53113, Germany

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Bergisch Gladbach, 51465, Germany

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Budapest, 1145, Hungary

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Debrecen, 4032, Hungary

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Győr, 9024, Hungary

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Miskolc, 3526, Hungary

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Nyíregyháza, 4400, Hungary

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Szeged, 6725, Hungary

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Szekszárd, 7100, Hungary

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Budapest, 1122, Hungary

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Budapest, 1062, Hungary

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Budapest, 1125, Hungary

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Delhi, 110029, India

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Jaipur, 302022, India

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Kanpur, 208005, India

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Kolkata, 700099, India

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Kolkata, 700160, India

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Mohali, 160055, India

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Nagpur, 440001, India

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New Delhi, 110085, India

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New Delhi, 11029, India

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Pune, 411004, India

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Surat, 395002, India

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Vadodara, 391760, India

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Varanasi, 221005, India

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Bangalore, 560027, India

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Calicut, 673601, India

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Hyderabad, 500032, India

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Meldola, 47014, Italy

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Trento, 38100, Italy

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Milan, 20132, Italy

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Milan, 20133, Italy

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Terni, 05100, Italy

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Napoli, 80131, Italy

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Padua, 35128, Italy

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Rome, 00168, Italy

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Rozzano, 20089, Italy

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Bari, 70124, Italy

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Genoa, 16132, Italy

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Sagamihara-shi, 252-0375, Japan

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Chiba, 260-8717, Japan

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Fukuoka, 811-1347, Japan

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Fukuoka, 812-8582, Japan

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Hirakata-shi, 573-1191, Japan

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Hirosaki-shi, 036-8563, Japan

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Kanazawa, 920-8641, Japan

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Kashihara-shi, 634-8522, Japan

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Kawagoe-shi, 350-8550, Japan

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Kisarazu-shi, 292-8535, Japan

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Kita-gun, 761-0793, Japan

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Kobe, 650-0047, Japan

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Kumamoto, 860-0008, Japan

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Kyoto, 606-8507, Japan

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Maebashi, 371-8811, Japan

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Nagano, 381-8551, Japan

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Nagasaki, 852-8501, Japan

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Nagoya, 466-8560, Japan

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Nagoya, 466-8650, Japan

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Osaka, 541-8567, Japan

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Osakasayama-shi, 589-8511, Japan

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Sakura-shi, 285-8741, Japan

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Sapporo, 060-8638, Japan

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Shiwa-gun, 028-3695, Japan

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Suita-shi, 565-0871, Japan

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Tsu, 514-8507, Japan

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Yokohama, 232-0024, Japan

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Yufu-shi, 879-5593, Japan

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Johor Bahru, 81100, Malaysia

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Kota Kinabalu, 88996, Malaysia

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Kuala Lumpur, 50586, Malaysia

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Kuala Lumpur, 59100, Malaysia

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Kuching, 93586, Malaysia

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George Town, 10450, Malaysia

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Hilversum, 1213 XZ, Netherlands

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Nijmegen, 6525 GA, Netherlands

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Amsterdam, 1066 CX, Netherlands

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Bellavista, CALLAO 2, Peru

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Lima, 15036, Peru

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Lima, 15082, Peru

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Lima, 15102, Peru

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Research Site

Lima, 34, Peru

No email / No phone

Status: Active, not recruiting

Research Site

Lima, LIMA 29, Peru

No email / No phone

Status: Active, not recruiting

Research Site

Arequipa, AREQUIPA01, Peru

No email / No phone

Status: Recruiting

Research Site

Bydgoszcz, 85-796, Poland

No email / No phone

Status: Active, not recruiting

Research Site

Poznan, 61-731, Poland

No email / No phone

Status: Active, not recruiting

Research Site

Rzeszów, 35-001, Poland

No email / No phone

Status: Active, not recruiting

Research Site

Szczecin, 71-730, Poland

No email / No phone

Status: Withdrawn

Research Site

Warsaw, 04-073, Poland

No email / No phone

Status: Active, not recruiting

Research Site

Wroclaw, 53-329, Poland

No email / No phone

Status: Active, not recruiting

Research Site

Żory, 44-240, Poland

No email / No phone

Status: Withdrawn

Research Site

Koszalin, 75-581, Poland

No email / No phone

Status: Active, not recruiting

Research Site

San Juan, 00927, Puerto Rico

No email / No phone

Status: Withdrawn

Research Site

Seongnam-si, 13620, South Korea

No email / No phone

Status: Active, not recruiting

Research Site

Daejeon, 35015, South Korea

No email / No phone

Status: Active, not recruiting

Research Site

Seoul, 03080, South Korea

No email / No phone

Status: Active, not recruiting

Research Site

Seoul, 03722, South Korea

No email / No phone

Status: Active, not recruiting

Research Site

Seoul, 05505, South Korea

No email / No phone

Status: Active, not recruiting

Research Site

Seoul, 06351, South Korea

No email / No phone

Status: Active, not recruiting

Research Site

Seoul, 06591, South Korea

No email / No phone

Status: Active, not recruiting

Research Site

Suwon, 16247, South Korea

No email / No phone

Status: Active, not recruiting

Research Site

Lugo, 27003, Spain

No email / No phone

Status: Recruiting

Research Site

Barcelona, 08035, Spain

No email / No phone

Status: Recruiting

Research Site

Córdoba, 14004, Spain

No email / No phone

Status: Recruiting

Research Site

L'Hospitalet de Llobregat, 08908, Spain

No email / No phone

Status: Recruiting

Research Site

Madrid, 28034, Spain

No email / No phone

Status: Recruiting

Research Site

Valencia, 46014, Spain

No email / No phone

Status: Recruiting

Research Site

Madrid, 28040, Spain

No email / No phone

Status: Recruiting

Research Site

Madrid, 28041, Spain

No email / No phone

Status: Recruiting

Research Site

Sabadell, 08208, Spain

No email / No phone

Status: Recruiting

Research Site

Stockholm, 118 83, Sweden

No email / No phone

Status: Withdrawn

Research Site

Solna, 171 64, Sweden

No email / No phone

Status: Withdrawn

Research Site

Malmo, 20502, Sweden

No email / No phone

Status: Withdrawn

Research Site

Gothenburg, 413 45, Sweden

No email / No phone

Status: Withdrawn

Research Site

Kaohsiung City, 833, Taiwan

No email / No phone

Status: Recruiting

Research Site

Yung Kang City, 71044, Taiwan

No email / No phone

Status: Recruiting

Research Site

Taoyuan District, 333, Taiwan

No email / No phone

Status: Recruiting

Research Site

Taichung, 43503, Taiwan

No email / No phone

Status: Recruiting

Research Site

Taichung, 40447, Taiwan

No email / No phone

Status: Recruiting

Research Site

Kaohsiung City, 80756, Taiwan

No email / No phone

Status: Recruiting

Research Site

Bangkok, 10210, Thailand

No email / No phone

Status: Active, not recruiting

Research Site

Songkhla, 90110, Thailand

No email / No phone

Status: Active, not recruiting

Research Site

Khlong Luang, 12120, Thailand

No email / No phone

Status: Active, not recruiting

Research Site

Chiang Mai, 50200, Thailand

No email / No phone

Status: Active, not recruiting

Research Site

Bangkok, 10700, Thailand

No email / No phone

Status: Active, not recruiting

Research Site

Bangkok, 10330, Thailand

No email / No phone

Status: Active, not recruiting

Research Site

Karşıyaka, 35575, Turkey (Türkiye)

No email / No phone

Status: Recruiting

Research Site

Istanbul, 34722, Turkey (Türkiye)

No email / No phone

Status: Recruiting

Research Site

Fatih-Istanbul, 34098, Turkey (Türkiye)

No email / No phone

Status: Recruiting

Research Site

Bornova-Izmir, 35100, Turkey (Türkiye)

No email / No phone

Status: Recruiting

Research Site

Ankara, 06590, Turkey (Türkiye)

No email / No phone

Status: Recruiting

Research Site

Ankara, 06340, Turkey (Türkiye)

No email / No phone

Status: Recruiting

Research Site

Aberdeen, AB25 2ZN, United Kingdom

No email / No phone

Status: Recruiting

Research Site

Manchester, M20 4BX, United Kingdom

No email / No phone

Status: Recruiting

Research Site

Birmingham, B15 2GW, United Kingdom

No email / No phone

Status: Recruiting

Research Site

Cambridge, CB2 0QQ, United Kingdom

No email / No phone

Status: Recruiting

Research Site

Glasgow, G12 0YN, United Kingdom

No email / No phone

Status: Recruiting

Research Site

Guildford, GU2 7XX, United Kingdom

No email / No phone

Status: Recruiting

Research Site

London, EC1A 7BE, United Kingdom

No email / No phone

Status: Recruiting

Research Site

London, W6 8RF, United Kingdom

No email / No phone

Status: Recruiting

Research Site

Truro, TR1 3LJ, United Kingdom

No email / No phone

Status: Recruiting

Research Site

Swansea, SA2 8QA, United Kingdom

No email / No phone

Status: Withdrawn

Research Site

Preston, PR2 9HT, United Kingdom

No email / No phone

Status: Recruiting

Research Site

Plymouth, PL6 8DH, United Kingdom

No email / No phone

Status: Recruiting

Research Site

Oxford, OX3 7LE, United Kingdom

No email / No phone

Status: Recruiting

Research Site

Newcastle upon Tyne, NE7 7AF, United Kingdom

No email / No phone

Status: Recruiting

Research Site

Phoenix, Arizona, 85054, United States

No email / No phone

Status: Recruiting

Research Site

Chandler, Arizona, 85224, United States

No email / No phone

Status: Recruiting

Research Site

Gilbert, Arizona, 85234, United States

No email / No phone

Status: Recruiting

Research Site

Tucson, Arizona, 85741, United States

No email / No phone

Status: Recruiting

Research Site

Little Rock, Arkansas, 72205, United States

No email / No phone

Status: Recruiting

Research Site

Springdale, Arkansas, 72762, United States

No email / No phone

Status: Recruiting

Research Site

Santa Monica, California, 90404, United States

No email / No phone

Status: Recruiting

Research Site

Bakersfield, California, 93301, United States

No email / No phone

Status: Recruiting

Research Site

Fountain Valley, California, 92708, United States

No email / No phone

Status: Recruiting

Research Site

Fullerton, California, 92835, United States

No email / No phone

Status: Recruiting

Research Site

Los Angeles, California, 90073, United States

No email / No phone

Status: Recruiting

Research Site

Los Angeles, California, 90095, United States

No email / No phone

Status: Withdrawn

Research Site

Montebello, California, 90640, United States

No email / No phone

Status: Recruiting

Research Site

Pasadena, California, 91101, United States

No email / No phone

Status: Withdrawn

Research Site

Pomona, California, 91767, United States

No email / No phone

Status: Withdrawn

Research Site

Sacramento, California, 95816, United States

No email / No phone

Status: Withdrawn

Research Site

San Diego, California, 92123, United States

No email / No phone

Status: Withdrawn

Research Site

San Francisco, California, 94115, United States

No email / No phone

Status: Recruiting

Research Site

Santa Barbara, California, 93105, United States

No email / No phone

Status: Recruiting

Research Site

Santa Rosa, California, 95403, United States

No email / No phone

Status: Recruiting

Research Site

Golden, Colorado, 80401, United States

No email / No phone

Status: Recruiting

Research Site

Lakewood, Colorado, 80228, United States

No email / No phone

Status: Recruiting

Research Site

Norwich, Connecticut, 06360, United States

No email / No phone

Status: Withdrawn

Research Site

New Haven, Connecticut, 06510, United States

No email / No phone

Status: Recruiting

Research Site

Newark, Delaware, 19713, United States

No email / No phone

Status: Withdrawn

Research Site

Tampa, Florida, 33612, United States

No email / No phone

Status: Withdrawn

Research Site

St. Petersburg, Florida, 33705, United States

No email / No phone

Status: Withdrawn

Research Site

Palm Bay, Florida, 32909, United States

No email / No phone

Status: Withdrawn

Research Site

Jacksonville, Florida, 32224, United States

No email / No phone

Status: Withdrawn

Research Site

Jacksonville, Florida, 32209, United States

No email / No phone

Status: Withdrawn

Research Site

Atlanta, Georgia, 30318, United States

No email / No phone

Status: Recruiting

Research Site

Lake Barrington, Illinois, 60010, United States

No email / No phone

Status: Recruiting

Research Site

Glenview, Illinois, 60026, United States

No email / No phone

Status: Recruiting

Research Site

Indianapolis, Indiana, 46202, United States

No email / No phone

Status: Recruiting

Research Site

Fort Wayne, Indiana, 46804, United States

No email / No phone

Status: Recruiting

Research Site

Des Moines, Iowa, 50309, United States

No email / No phone

Status: Withdrawn

Research Site

Westwood, Kansas, 66205, United States

No email / No phone

Status: Recruiting

Research Site

Wichita, Kansas, 67226, United States

No email / No phone

Status: Withdrawn

Research Site

Lexington, Kentucky, 40503, United States

No email / No phone

Status: Withdrawn

Research Site

Louisville, Kentucky, 40202, United States

No email / No phone

Status: Withdrawn

Research Site

Shreveport, Louisiana, 71103, United States

No email / No phone

Status: Recruiting

Research Site

Scarborough, Maine, 04074, United States

No email / No phone

Status: Recruiting

Research Site

Towson, Maryland, 21204, United States

No email / No phone

Status: Recruiting

Research Site

Baltimore, Maryland, 21201, United States

No email / No phone

Status: Recruiting

Research Site

Baltimore, Maryland, 21287, United States

No email / No phone

Status: Recruiting

Research Site

Bethesda, Maryland, 20817, United States

No email / No phone

Status: Recruiting

Research Site

Upper Marlboro, Maryland, 20774, United States

No email / No phone

Status: Recruiting

Research Site

Troy, Michigan, 48084, United States

No email / No phone

Status: Recruiting

Research Site

Grand Rapids, Michigan, 49503, United States

No email / No phone

Status: Recruiting

Research Site

Rochester, Minnesota, 55905, United States

No email / No phone

Status: Recruiting

Research Site

Columbia, Missouri, 65212, United States

No email / No phone

Status: Withdrawn

Research Site

Billings, Montana, 59102, United States

No email / No phone

Status: Withdrawn

Research Site

Bozeman, Montana, 59715, United States

No email / No phone

Status: Recruiting

Research Site

Las Vegas, Nevada, 89102, United States

No email / No phone

Status: Recruiting

Research Site

Las Vegas, Nevada, 89148, United States

No email / No phone

Status: Recruiting

Research Site

Voorhees Township, New Jersey, 08043, United States

No email / No phone

Status: Withdrawn

Research Site

East Brunswick, New Jersey, 08816, United States

No email / No phone

Status: Withdrawn

Research Site

Belleville, New Jersey, 07109, United States

No email / No phone

Status: Withdrawn

Research Site

Brick, New Jersey, 08724, United States

No email / No phone

Status: Withdrawn

Research Site

Camden, New Jersey, 08103, United States

No email / No phone

Status: Recruiting

Research Site

Albuquerque, New Mexico, 87110, United States

No email / No phone

Status: Withdrawn

Research Site

Albuquerque, New Mexico, 87109, United States

No email / No phone

Status: Recruiting

Research Site

Rio Rancho, New Mexico, 87124, United States

No email / No phone

Status: Withdrawn

Research Site

Syracuse, New York, 13210, United States

No email / No phone

Status: Recruiting

Research Site

Albany, New York, 12206, United States

No email / No phone

Status: Withdrawn

Research Site

East Syracuse, New York, 13057, United States

No email / No phone

Status: Recruiting

Research Site

New Hyde Park, New York, 11042, United States

No email / No phone

Status: Recruiting

Research Site

New York, New York, 10028, United States

No email / No phone

Status: Withdrawn

Research Site

New York, New York, 10029, United States

No email / No phone

Status: Recruiting

Research Site

Shirley, New York, 11967, United States

No email / No phone

Status: Withdrawn

Research Site

The Bronx, New York, 10469, United States

No email / No phone

Status: Withdrawn

Research Site

Durham, North Carolina, 27710, United States

No email / No phone

Status: Recruiting

Research Site

Fayetteville, North Carolina, 28303, United States

No email / No phone

Status: Withdrawn

Research Site

Cincinnati, Ohio, 45212, United States

No email / No phone

Status: Recruiting

Research Site

Cincinnati, Ohio, 45219, United States

No email / No phone

Status: Recruiting

Research Site

Cleveland, Ohio, 44109, United States

No email / No phone

Status: Withdrawn

Research Site

Cleveland, Ohio, 44111, United States

No email / No phone

Status: Recruiting

Research Site

Cleveland, Ohio, 44124, United States

No email / No phone

Status: Recruiting

Research Site

Cleveland, Ohio, 44130, United States

No email / No phone

Status: Withdrawn

Research Site

Columbus, Ohio, 43210, United States

No email / No phone

Status: Recruiting

Research Site

Independence, Ohio, 44131, United States

No email / No phone

Status: Withdrawn

Research Site

Wooster, Ohio, 44691, United States

No email / No phone

Status: Withdrawn

Research Site

Portland, Oregon, 97227, United States

No email / No phone

Status: Recruiting

Research Site

Portland, Oregon, 97239, United States

No email / No phone

Status: Withdrawn

Research Site

Florence, Oregon, 97439, United States

No email / No phone

Status: Withdrawn

Research Site

Pittsburgh, Pennsylvania, 15212, United States

No email / No phone

Status: Recruiting

Research Site

Pittsburgh, Pennsylvania, 15213, United States

No email / No phone

Status: Withdrawn

Research Site

York, Pennsylvania, 17403, United States

No email / No phone

Status: Withdrawn

Research Site

Bala-Cynwyd, Pennsylvania, 19004-1017, United States

No email / No phone

Status: Recruiting

Research Site

Philadelphia, Pennsylvania, 19104, United States

No email / No phone

Status: Recruiting

Research Site

Providence, Rhode Island, 02903, United States

No email / No phone

Status: Recruiting

Research Site

North Charleston, South Carolina, 29406, United States

No email / No phone

Status: Recruiting

Research Site

Myrtle Beach, South Carolina, 29572, United States

No email / No phone

Status: Recruiting

Research Site

Sioux Falls, South Dakota, 57105, United States

No email / No phone

Status: Recruiting

Research Site

Nashville, Tennessee, 37203, United States

No email / No phone

Status: Recruiting

Research Site

Germantown, Tennessee, 38138, United States

No email / No phone

Status: Recruiting

Research Site

Wichita Falls, Texas, 76310, United States

No email / No phone

Status: Recruiting

Research Site

Dallas, Texas, 75231, United States

No email / No phone

Status: Recruiting

Research Site

Dallas, Texas, 75246, United States

No email / No phone

Status: Withdrawn

Research Site

Denton, Texas, 76201, United States

No email / No phone

Status: Withdrawn

Research Site

Flower Mound, Texas, 75028, United States

No email / No phone

Status: Withdrawn

Research Site

Grapevine, Texas, 76051, United States

No email / No phone

Status: Withdrawn

Research Site

Houston, Texas, 77025, United States

No email / No phone

Status: Recruiting

Research Site

Houston, Texas, 77027, United States

No email / No phone

Status: Withdrawn

Research Site

Houston, Texas, 77030, United States

No email / No phone

Status: Withdrawn

Research Site

Plano, Texas, 75093, United States

No email / No phone

Status: Withdrawn

Research Site

San Antonio, Texas, 78217, United States

No email / No phone

Status: Withdrawn

Research Site

San Antonio, Texas, 78229, United States

No email / No phone

Status: Recruiting

Research Site

Sugar Land, Texas, 77479, United States

No email / No phone

Status: Recruiting

Research Site

Tyler, Texas, 75702, United States

No email / No phone

Status: Recruiting

Research Site

Salt Lake City, Utah, 84106, United States

No email / No phone

Status: Recruiting

Research Site

Salt Lake City, Utah, 84132, United States

No email / No phone

Status: Recruiting

Research Site

St. George, Utah, 84790, United States

No email / No phone

Status: Recruiting

Research Site

Winchester, Virginia, 22601, United States

No email / No phone

Status: Withdrawn

Research Site

Fairfax, Virginia, 22031, United States

No email / No phone

Status: Recruiting

Research Site

Spokane Valley, Washington, 99216, United States

No email / No phone

Status: Withdrawn

Research Site

Spokane, Washington, 99202, United States

No email / No phone

Status: Recruiting

Research Site

Tacoma, Washington, 98405, United States

No email / No phone

Status: Recruiting

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