Sponsor: AstraZeneca (industry)
Phase: 3
Start date: Nov. 23, 2023
Planned enrollment: 625
Datopotamab deruxtecan (Dato-DXd, DS-1062) is an investigational antibody-drug conjugate (ADC) targeting trophoblast cell-surface antigen-2 (TROP2). It is being developed by Daiichi Sankyo and AstraZeneca for the treatment of various cancers, including non–small cell lung cancer (NSCLC) and breast cancer.
Dato-DXd comprises a humanized anti-TROP2 monoclonal antibody linked to a potent topoisomerase I inhibitor payload. Upon binding to TROP2-expressing tumor cells, the ADC is internalized, releasing the cytotoxic agent to induce DNA damage and cell death.
Non–Small Cell Lung Cancer (NSCLC):
TROPION-Lung05 Phase II Trial: In patients with advanced/metastatic NSCLC harboring actionable genomic alterations, Dato-DXd demonstrated an objective response rate (ORR) of 35.8%, with a median progression-free survival (PFS) of 5.4 months. (ascopubs.org)
TROPION-Lung01 Phase III Trial: Dato-DXd showed a statistically significant improvement in PFS compared to docetaxel in previously treated patients with locally advanced or metastatic NSCLC. (cms.dsi.com)
Breast Cancer:
TROPION-Breast01 Phase III Trial: In patients with inoperable or metastatic hormone receptor–positive, HER2-negative breast cancer, Dato-DXd significantly reduced the risk of disease progression or death by 37% compared to chemotherapy (hazard ratio [HR], 0.63; P < .0001). (ascopubs.org)
BEGONIA Phase 1b/2 Trial: In previously untreated metastatic triple-negative breast cancer, Dato-DXd combined with durvalumab achieved a confirmed ORR of 79%, including complete responses. (daiichisankyo.us)
In the TROPION-Breast01 trial, Dato-DXd exhibited a favorable safety profile, with grade ≥3 treatment-related adverse events (TRAEs) occurring in 20.8% of patients, compared to 44.7% in the chemotherapy group. Common TRAEs included nausea (51.1%; grade ≥3: 1.4%) and stomatitis (50%; grade ≥3: 6.4%). (ascopubs.org)
In the TROPION-Lung05 trial, grade ≥3 TRAEs were reported in 28.5% of patients, with stomatitis (10%) being the most common. There were five cases (3.6%) of treatment-related interstitial lung disease/pneumonitis, including one grade 5 event. (ascopubs.org)
Last updated: Apr 2025
The TROPION-Breast05 trial (NCT06103864) is a Phase III, open-label, randomized study evaluating the efficacy and safety of datopotamab deruxtecan (Dato-DXd) with or without durvalumab compared to investigator's choice of chemotherapy (paclitaxel, nab-paclitaxel, or gemcitabine plus carboplatin) in combination with pembrolizumab in patients with PD-L1–positive locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC).
The trial was initiated in December 2023, with the first patient dosed as part of a global effort to assess new treatment combinations for TNBC. The study aims to enroll approximately 625 patients across multiple countries, including the UK, South Korea, and Taiwan. The primary endpoint is progression-free survival (PFS) as assessed by blinded independent central review, with secondary endpoints including overall survival (OS), objective response rate (ORR), duration of response (DOR), and safety. (daiichisankyo.us)
Standard first-line treatment for patients with metastatic PD-L1–positive TNBC typically involves pembrolizumab combined with chemotherapy; however, prognosis remains poor, highlighting the need for more effective therapies. Dato-DXd is an antibody-drug conjugate targeting TROP2, a protein commonly expressed in TNBC, linked to a topoisomerase I inhibitor. Durvalumab is an anti-PD-L1 monoclonal antibody. Previous studies, such as the Phase I TROPION-PanTumor01 and the Phase Ib/II BEGONIA trials, have demonstrated manageable safety profiles and encouraging efficacy for Dato-DXd alone and in combination with durvalumab in heavily pretreated metastatic TNBC patients. (cancernetwork.com)
As of August 2025, the TROPION-Breast05 trial is actively recruiting participants. No early results have been reported yet. The oncology community is closely monitoring this trial, as it may provide valuable insights into the potential benefits of combining Dato-DXd with durvalumab for treating PD-L1–positive TNBC. The study's outcomes could influence future treatment guidelines and offer new hope for patients with this aggressive breast cancer subtype.
Last updated: Aug 2025
Goal: To determine whether datopotamab deruxtecan (Dato-DXd) with or without durvalumab improves progression-free survival compared to investigator's choice of chemotherapy (paclitaxel, nab-paclitaxel, or gemcitabine plus carboplatin) in combination with pembrolizumab for patients with PD-L1 positive, locally recurrent inoperable or metastatic triple-negative breast cancer (TNBC).
Patients: Patients enrolled have histologically or cytologically confirmed, locally recurrent inoperable or metastatic TNBC that is PD-L1 positive (CPS ≥ 10), with no prior chemotherapy or systemic therapy for metastatic or locally recurrent inoperable breast cancer. Eligible patients must have ECOG PS 0-1 and measurable disease per RECIST 1.1. Both male and female patients are eligible, with requirements for adequate organ function and tissue availability.
Design: This is a randomized, open-label, multicenter, international phase III study with three arms and stratification by geography, disease-free interval, and prior PD-1/PD-L1 exposure. Participants are randomized to one of three arms: Dato-DXd plus durvalumab, Dato-DXd monotherapy, or investigator’s choice chemotherapy with pembrolizumab.
Treatments: The investigational treatment is datopotamab deruxtecan (Dato-DXd), an antibody-drug conjugate targeting TROP2, linked to a topoisomerase I inhibitor payload. Dato-DXd binds TROP2 on tumor cells, is internalized, and delivers a cytotoxic agent that induces DNA damage; the membrane-permeable payload enables bystander killing. In prior phase III studies in lung and breast cancer, Dato-DXd showed improved progression-free survival (e.g., TROPION-Lung01 median PFS 4.4 vs 3.7 months vs docetaxel, HR 0.75), and a generally manageable safety profile, with stomatitis, nausea, and interstitial lung disease/pneumonitis among notable adverse events. Durvalumab, a PD-L1 inhibitor, is combined in one investigational arm. The comparator arm employs investigator’s choice of paclitaxel, nab-paclitaxel, or gemcitabine plus carboplatin, each in combination with pembrolizumab, an approved PD-1 inhibitor.
Outcomes: The primary endpoint is progression-free survival (PFS) by blinded independent central review per RECIST 1.1. Key secondary endpoints include overall survival (OS), objective response rate (ORR), duration of response, investigator-assessed PFS, clinical benefit rate at 24 weeks, various patient-reported outcomes (symptom and quality of life deterioration), time to first and second subsequent therapy, PFS2, pharmacokinetics and immunogenicity of Dato-DXd and its combination with durvalumab, and safety/tolerability measures.
Burden on patient: The patient burden is moderate and typical of international phase III registrational trials in metastatic breast cancer. Patients must provide tumor tissue for biomarker testing and undergo regular radiology assessments per RECIST, which are standard. Arm-specific procedures include intravenous administration of Dato-DXd and/or durvalumab under protocol-defined schedules, similar to chemotherapy plus pembrolizumab regimens. There may be additional pharmacokinetic and immunogenicity blood draws in the experimental arms, but otherwise, procedures align closely with standard of care; no research biopsies are described. Patient-reported outcome assessments are included but are non-invasive. Visits and imaging requirements reflect standard oncology practice for advanced breast cancer trials.
Key Inclusion Criteria
* Histologically or cytologically documented locally recurrent inoperable, which cannot be treated with curative intent, or metastatic TNBC, as defined by the ASCO-CAP guidelines.
* ECOG PS 0 or 1.
* Participants are expected to provide an FFPE tumour sample collected from a locally recurrent inoperable or metastatic tumour. If no such sample is available, an archival FFPE tumour sample can be submitted; it must have been collected ≤ 3 years prior to the participant signing informed consent (screening start).
* PD-L1 positive TNBC based on results from an appropriately validated investigational PD-L1 (22C3) assay (CPS ≥ 10) from a sponsor designated central laboratory.
* No prior chemotherapy or other systemic anti-cancer therapy for metastatic or locally recurrent inoperable breast cancer.
- Patients with recurrent disease will be eligible if they have completed treatment for Stage I-III breast cancer, if indicated, and ≥6 months have elapsed between completion of treatment with curative intent and the first documented recurrence.
* Eligible for one of the chemotherapy options listed as ICC (paclitaxel, nab-paclitaxel, or gemcitabine + carboplatin).
* Measurable disease as per RECIST 1.1.
* Adequate bone marrow reserve and organ function.
* Male and female participants of childbearing potential must agree to use protocol-specified method(s) of contraception.
Key Exclusion Criteria
* As judged by investigator, any evidence of diseases (such as severe or uncontrolled medical conditions including systemic diseases, uncontrolled hypertension, serious gastrointestinal conditions associated with diarrhoea, chronic diverticulitis or previous complicated diverticulitis, history of allogeneic organ transplant, and active bleeding diseases, ongoing and active infection, significant cardiac conditions, substance abuse, psychiatric illness/social situation or psychological conditions) which, in the investigator's opinion, makes it undesirable for the participant to participate in the study or that would jeopardize compliance with the protocol.
* History of another primary malignancy except for malignancy treated with curative intent with no known active disease within 3 years before Cycle 1 Day 1 and of low potential risk for recurrence.
* Participants with a history of previously treated neoplastic spinal cord compression or treated, clinically inactive brain metastases that are no longer symptomatic, who require no treatment with corticosteroids or anticonvulsants, may be included in the study if they have recovered from acute toxic effects of radiotherapy.
- Participants with treated clinically inactive brain metastases that are no longer symptomatic, who require no treatment with corticosteroids or anticonvulsants, may be included in the study if they have recovered from acute toxic effects of radiotherapy.
* Uncontrolled infection requiring IV antibiotics, antivirals or antifungals.
* Active or uncontrolled hepatitis B or C virus infection.
* Known HIV infection that is not well controlled.
* Uncontrolled or significant cardiac disease.
* History of non-infectious ILD/pneumonitis (including radiation pneumonitis) that required steroids, current ILD/pneumonitis, or suspected ILD/pneumonitis that cannot be ruled out by imaging at screening.
* Severe pulmonary function compromise.
* Clinically significant corneal disease.
* Active or prior documented autoimmune or inflammatory disorders.
* Prior exposure to any treatment including ADC containing a chemotherapeutic agent targeting topoisomerase I and TROP2-targeted therapy.
* Any concurrent anti-cancer treatment.
* Participants with a known severe hypersensitivity to PD-1/PD-L1 inhibitors or Dato-DXd.
* Currently pregnant (confirmed with positive pregnancy test), breastfeeding or planning to become pregnant.
Caba, 1414, Argentina
No email / No phone
Status: Recruiting
Buenos Aires, C1125ABD, Argentina
No email / No phone
Status: Recruiting
Ciudad Autonoma Bs As, C1015ABO, Argentina
No email / No phone
Status: Recruiting
Rosario, 2000, Argentina
No email / No phone
Status: Recruiting
San Nicolas de Los Arroyos, B2900, Argentina
No email / No phone
Status: Recruiting
Caba, C1425, Argentina
No email / No phone
Status: Withdrawn
Caba, 1425, Argentina
No email / No phone
Status: Recruiting
Darlinghurst, 2010, Australia
No email / No phone
Status: Recruiting
Heidelberg, 3084, Australia
No email / No phone
Status: Recruiting
Melbourne, 3000, Australia
No email / No phone
Status: Recruiting
Nedlands, 6009, Australia
No email / No phone
Status: Recruiting
Waratah, 2298, Australia
No email / No phone
Status: Recruiting
Camperdown, 2050, Australia
No email / No phone
Status: Recruiting
Itajai, 88301-220, Brazil
No email / No phone
Status: Recruiting
Florianópolis, 88034-000, Brazil
No email / No phone
Status: Recruiting
Curitiba, 80730-150, Brazil
No email / No phone
Status: Recruiting
Barretos, 14784-400, Brazil
No email / No phone
Status: Recruiting
Teresina, 64049-200, Brazil
No email / No phone
Status: Recruiting
São Paulo, 01317-001, Brazil
No email / No phone
Status: Recruiting
Sao Paulo, 01246-000, Brazil
No email / No phone
Status: Recruiting
Recife, 52010-075, Brazil
No email / No phone
Status: Recruiting
Porto Alegre, 90035-003, Brazil
No email / No phone
Status: Recruiting
Goiânia, 74000-000, Brazil
No email / No phone
Status: Recruiting
Toronto, Ontario, M5G 2M9, Canada
No email / No phone
Status: Recruiting
Hamilton, Ontario, L8V 5C2, Canada
No email / No phone
Status: Not yet recruiting
Barrie, Ontario, L4M 6M2, Canada
No email / No phone
Status: Recruiting
Greenfield Park, Quebec, J4V 2H1, Canada
No email / No phone
Status: Recruiting
Montréal, Quebec, H2X 0A9, Canada
No email / No phone
Status: Recruiting
Montreal, Quebec, H4A 3J1, Canada
No email / No phone
Status: Recruiting
Saskatoon, Saskatchewan, S7N 4H4, Canada
No email / No phone
Status: Recruiting
Regina, Saskatchewan, S4T 7T1, Canada
No email / No phone
Status: Recruiting
Quebec, G1S 4L8, Canada
No email / No phone
Status: Recruiting
Changsha, 410008, China
No email / No phone
Status: Recruiting
Changchun, 130021, China
No email / No phone
Status: Recruiting
Bengbu, 233004, China
No email / No phone
Status: Recruiting
Beijing, 100142, China
No email / No phone
Status: Recruiting
Beijing, 100044, China
No email / No phone
Status: Recruiting
Zhengzhou, 450052, China
No email / No phone
Status: Recruiting
Zhengzhou, 450008, China
No email / No phone
Status: Recruiting
Xuzhou, 221009, China
No email / No phone
Status: Recruiting
Xintai, 54031, China
No email / No phone
Status: Recruiting
Xiamen, 361003, China
No email / No phone
Status: Recruiting
Xi'an, 710061, China
No email / No phone
Status: Recruiting
Wuhan, 430079, China
No email / No phone
Status: Recruiting
Wuhan, 430022, China
No email / No phone
Status: Recruiting
Wenzhou, 325000, China
No email / No phone
Status: Recruiting
Tianjin, 300000, China
No email / No phone
Status: Recruiting
Shenyang, 110004, China
No email / No phone
Status: Recruiting
Shanghai, 200080, China
No email / No phone
Status: Recruiting
Shanghai, 200025, China
No email / No phone
Status: Recruiting
Shandong, China
No email / No phone
Status: Recruiting
Nanning, 530021, China
No email / No phone
Status: Recruiting
Nanjing, 210009, China
No email / No phone
Status: Recruiting
Nanjing, 2100008, China
No email / No phone
Status: Recruiting
Nanchang, 330009, China
No email / No phone
Status: Recruiting
Ji Nan, 250021, China
No email / No phone
Status: Recruiting
Hefei, 230031, China
No email / No phone
Status: Recruiting
Harbin, 150081, China
No email / No phone
Status: Recruiting
Hangzhou, 310022, China
No email / No phone
Status: Recruiting
Hangzhou, 310016, China
No email / No phone
Status: Recruiting
Guangzhou, 510700, China
No email / No phone
Status: Recruiting
Guangzhou, 510120, China
No email / No phone
Status: Recruiting
Guangzhou, 510060, China
No email / No phone
Status: Recruiting
Fuzhou, 350014, China
No email / No phone
Status: Recruiting
Chongqing, 400030, China
No email / No phone
Status: Withdrawn
Chengdu, 610041, China
No email / No phone
Status: Recruiting
Chengdu, 610000, China
No email / No phone
Status: Recruiting
Changsha, 410013, China
No email / No phone
Status: Recruiting
Lille, 59000, France
No email / No phone
Status: Not yet recruiting
Toulouse Cedex 9, 31059, France
No email / No phone
Status: Recruiting
Vandoeuvre-lès-nancy, 54511, France
No email / No phone
Status: Recruiting
Villejuif, 94800, France
No email / No phone
Status: Recruiting
Lyon, 69373, France
No email / No phone
Status: Not yet recruiting
Saint Herblain Cedex, 44805, France
No email / No phone
Status: Recruiting
Paris, 75020, France
No email / No phone
Status: Not yet recruiting
Leipzig, 04103, Germany
No email / No phone
Status: Withdrawn
Georgsmarienhütte, 49124, Germany
No email / No phone
Status: Withdrawn
Düsseldorf, 40479, Germany
No email / No phone
Status: Withdrawn
Essen, 45136, Germany
No email / No phone
Status: Withdrawn
Hamburg, 20357, Germany
No email / No phone
Status: Withdrawn
Hannover, 30625, Germany
No email / No phone
Status: Withdrawn
Heidelberg, 69120, Germany
No email / No phone
Status: Withdrawn
Heilbronn, 74078, Germany
No email / No phone
Status: Withdrawn
Hong Kong, 999077, Hong Kong
No email / No phone
Status: Not yet recruiting
Hong Kong, HKG, Hong Kong
No email / No phone
Status: Not yet recruiting
Nagpur, 440001, India
No email / No phone
Status: Recruiting
Calicut, 673601, India
No email / No phone
Status: Withdrawn
Chennai, 600031, India
No email / No phone
Status: Recruiting
Kochi, 682027, India
No email / No phone
Status: Withdrawn
Kolkata, 700160, India
No email / No phone
Status: Withdrawn
Marg Jaipur, 302004, India
No email / No phone
Status: Recruiting
Mohali, 160055, India
No email / No phone
Status: Recruiting
Mysuru, 570017, India
No email / No phone
Status: Recruiting
Nashik, 422009, India
No email / No phone
Status: Recruiting
New Delhi, 110075, India
No email / No phone
Status: Recruiting
New Delhi, 11029, India
No email / No phone
Status: Recruiting
Pondicherry, 605006, India
No email / No phone
Status: Recruiting
Surat, 395002, India
No email / No phone
Status: Recruiting
Thiruvananthapuram, 695011, India
No email / No phone
Status: Not yet recruiting
Vadodara, 391760, India
No email / No phone
Status: Recruiting
Vishakapatnam, 530053, India
No email / No phone
Status: Withdrawn
Rozzano, 20089, Italy
No email / No phone
Status: Recruiting
Roma, 00168, Italy
No email / No phone
Status: Recruiting
Bergamo, 24127, Italy
No email / No phone
Status: Not yet recruiting
Reggio Emilia, 42123, Italy
No email / No phone
Status: Not yet recruiting
Padova, 35128, Italy
No email / No phone
Status: Recruiting
Napoli, 80131, Italy
No email / No phone
Status: Recruiting
Modena, 41124, Italy
No email / No phone
Status: Withdrawn
Milan, 20141, Italy
No email / No phone
Status: Recruiting
Milano, 20132, Italy
No email / No phone
Status: Not yet recruiting
Empoli, 50053, Italy
No email / No phone
Status: Recruiting
Sendai-shi, 980-8574, Japan
No email / No phone
Status: Recruiting
Nishinomiya-shi, 663-8501, Japan
No email / No phone
Status: Recruiting
Yokohama-shi, 241-8515, Japan
No email / No phone
Status: Recruiting
Niigata-shi, 951-8566, Japan
No email / No phone
Status: Recruiting
Nagoya-shi, 467-8602, Japan
No email / No phone
Status: Recruiting
Nagoya-shi, 466-8560, Japan
No email / No phone
Status: Recruiting
Matsuyama-shi, 791-0280, Japan
No email / No phone
Status: Recruiting
Kurume-shi, 830-0011, Japan
No email / No phone
Status: Recruiting
Kumamoto-shi, 860-8556, Japan
No email / No phone
Status: Recruiting
Koto-ku, 135-8550, Japan
No email / No phone
Status: Recruiting
Kitaadachi-gun, 362-0806, Japan
No email / No phone
Status: Recruiting
Kashiwa, 277-8577, Japan
No email / No phone
Status: Recruiting
Kamogawa-shi, 296-8602, Japan
No email / No phone
Status: Recruiting
Isehara-shi, 259-1193, Japan
No email / No phone
Status: Recruiting
Hiroshima-shi, 734-8551, Japan
No email / No phone
Status: Recruiting
Hiroshima-shi, 730-8518, Japan
No email / No phone
Status: Recruiting
Hidaka-shi, 350-1298, Japan
No email / No phone
Status: Recruiting
Osaka-shi, 541-8567, Japan
No email / No phone
Status: Recruiting
Fukuoka-shi, 811-1395, Japan
No email / No phone
Status: Recruiting
Chuo-ku, 104-0045, Japan
No email / No phone
Status: Recruiting
Chiba-shi, 260-8717, Japan
No email / No phone
Status: Recruiting
Bunkyo-ku, 113-8677, Japan
No email / No phone
Status: Recruiting
Bunkyo-ku, 113-8431, Japan
No email / No phone
Status: Recruiting
Akashi-shi, 673-8558, Japan
No email / No phone
Status: Recruiting
Fukushima-shi, 960-1295, Japan
No email / No phone
Status: Recruiting
Gifu-shi, 501-1194, Japan
No email / No phone
Status: Recruiting
Osakasayama-shi, 589-8511, Japan
No email / No phone
Status: Recruiting
Ota-shi, 373-8550, Japan
No email / No phone
Status: Recruiting
Sapporo-shi, 003-0804, Japan
No email / No phone
Status: Recruiting
Okayama-shi, 700-8558, Japan
No email / No phone
Status: Recruiting
Tsukuba, 305-8577, Japan
No email / No phone
Status: Recruiting
Tsu-shi, 514-8507, Japan
No email / No phone
Status: Recruiting
Shinjuku-ku, 162-8655, Japan
No email / No phone
Status: Recruiting
Shinjuku-ku, 160-0023, Japan
No email / No phone
Status: Recruiting
Shinagawa-ku, 142-8666, Japan
No email / No phone
Status: Recruiting
Seoul, 06351, Korea, Republic of
No email / No phone
Status: Recruiting
Busan, 49241, Korea, Republic of
No email / No phone
Status: Completed
Daegu, 41404, Korea, Republic of
No email / No phone
Status: Recruiting
Goyang-si, 10408, Korea, Republic of
No email / No phone
Status: Recruiting
Seongnam-si, 13620, Korea, Republic of
No email / No phone
Status: Not yet recruiting
Seoul, 02841, Korea, Republic of
No email / No phone
Status: Recruiting
Seoul, 03080, Korea, Republic of
No email / No phone
Status: Recruiting
Seoul, 03722, Korea, Republic of
No email / No phone
Status: Recruiting
Seoul, 05505, Korea, Republic of
No email / No phone
Status: Recruiting
Seoul, 06273, Korea, Republic of
No email / No phone
Status: Recruiting
Seoul, 06591, Korea, Republic of
No email / No phone
Status: Recruiting
CD Mexico, 04980, Mexico
No email / No phone
Status: Not yet recruiting
Guadalajara, 44638, Mexico
No email / No phone
Status: Not yet recruiting
Guadalajara, 44670, Mexico
No email / No phone
Status: Withdrawn
Mexico, 6760, Mexico
No email / No phone
Status: Not yet recruiting
México, 04700, Mexico
No email / No phone
Status: Not yet recruiting
Mexico City, 0 3100, Mexico
No email / No phone
Status: Recruiting
Tuxtla Gutierrez, 29090, Mexico
No email / No phone
Status: Not yet recruiting
Muntinlupa City, 1780, Philippines
No email / No phone
Status: Recruiting
Bacolod, 6100, Philippines
No email / No phone
Status: Recruiting
Manila, 1000, Philippines
No email / No phone
Status: Recruiting
Cebu City, 6000, Philippines
No email / No phone
Status: Recruiting
San Juan, 1502, Philippines
No email / No phone
Status: Recruiting
Quezon City, 1112, Philippines
No email / No phone
Status: Recruiting
Konin, 62-500, Poland
No email / No phone
Status: Withdrawn
Łódź, 90-302, Poland
No email / No phone
Status: Withdrawn
Wroclaw, 53-413, Poland
No email / No phone
Status: Withdrawn
Warszawa, 02-781, Poland
No email / No phone
Status: Withdrawn
Przemysl, 37-700, Poland
No email / No phone
Status: Withdrawn
Lublin, 20-090, Poland
No email / No phone
Status: Withdrawn
Legnica, 59-220, Poland
No email / No phone
Status: Withdrawn
Kraków, 31-501, Poland
No email / No phone
Status: Withdrawn
Kraków, 31-115, Poland
No email / No phone
Status: Withdrawn
Gdynia, 81-519, Poland
No email / No phone
Status: Withdrawn
Gdańsk, 80-952, Poland
No email / No phone
Status: Withdrawn
Bydgoszcz, 85-796, Poland
No email / No phone
Status: Withdrawn
Białystok, 15-027, Poland
No email / No phone
Status: Withdrawn
Singapore, 169610, Singapore
No email / No phone
Status: Not yet recruiting
Singapore, 308433, Singapore
No email / No phone
Status: Not yet recruiting
Singapore, 329563, Singapore
No email / No phone
Status: Not yet recruiting
Singapore, 119228, Singapore
No email / No phone
Status: Withdrawn
Johannesburg, 2196, South Africa
No email / No phone
Status: Recruiting
Pretoria, 0081, South Africa
No email / No phone
Status: Recruiting
Paarl, 7646, South Africa
No email / No phone
Status: Recruiting
Cape Town, 7570, South Africa
No email / No phone
Status: Recruiting
Johannesburg, 2013, South Africa
No email / No phone
Status: Recruiting
Johannesburg, 2193, South Africa
No email / No phone
Status: Recruiting
Madrid, 28007, Spain
No email / No phone
Status: Recruiting
Barcelona, 08028, Spain
No email / No phone
Status: Withdrawn
Barcelona, 8035, Spain
No email / No phone
Status: Recruiting
Granada, 18016, Spain
No email / No phone
Status: Recruiting
Hospitalet deLlobregat, 08907, Spain
No email / No phone
Status: Recruiting
Madrid, 28034, Spain
No email / No phone
Status: Withdrawn
Pamplona, 31008, Spain
No email / No phone
Status: Recruiting
Santander, 39008, Spain
No email / No phone
Status: Recruiting
Taipei, 11259, Taiwan
No email / No phone
Status: Recruiting
Taipei, 10449, Taiwan
No email / No phone
Status: Recruiting
Taipei, 100, Taiwan
No email / No phone
Status: Recruiting
Tainan, 704, Taiwan
No email / No phone
Status: Recruiting
Taichung, 40447, Taiwan
No email / No phone
Status: Recruiting
Kaohsiung, 80756, Taiwan
No email / No phone
Status: Recruiting
Hsinchu, 300, Taiwan
No email / No phone
Status: Recruiting
Taoyuan, 333, Taiwan
No email / No phone
Status: Recruiting
Dusit, 10300, Thailand
No email / No phone
Status: Recruiting
Chiang Mai, 50200, Thailand
No email / No phone
Status: Recruiting
Bangkok, 10400, Thailand
No email / No phone
Status: Recruiting
Bangkok, 10330, Thailand
No email / No phone
Status: Recruiting
Bangkok, 10210, Thailand
No email / No phone
Status: Recruiting
Songkhla, 90110, Thailand
No email / No phone
Status: Recruiting
Khon Kaen, 40002, Thailand
No email / No phone
Status: Recruiting
Samsun, 55200, Turkey
No email / No phone
Status: Not yet recruiting
Izmir, 35575, Turkey
No email / No phone
Status: Not yet recruiting
Besevler Ankara, Turkey
No email / No phone
Status: Not yet recruiting
Ankara, 6200, Turkey
No email / No phone
Status: Not yet recruiting
Ankara, 06520, Turkey
No email / No phone
Status: Recruiting
Küçükçekmece, 34295, Turkey
No email / No phone
Status: Not yet recruiting
Chelsea, SW3 6JJ, United Kingdom
No email / No phone
Status: Recruiting
London, SW17 0QT, United Kingdom
No email / No phone
Status: Withdrawn
London, EC1A 7BE, United Kingdom
No email / No phone
Status: Recruiting
Liverpool, L7 8YA, United Kingdom
No email / No phone
Status: Recruiting
Leicester, Le5 4PW, United Kingdom
No email / No phone
Status: Recruiting
Cardiff, CF14 2TL, United Kingdom
No email / No phone
Status: Recruiting
Taunton, TA1 5DA, United Kingdom
No email / No phone
Status: Recruiting
Sutton, SM2 5PT, United Kingdom
No email / No phone
Status: Recruiting
Surrey, GU2 7XX, United Kingdom
No email / No phone
Status: SUSPENDED
Oxford, OX3 7LE, United Kingdom
No email / No phone
Status: Recruiting
Daphne, Alabama, 36526, United States
No email / No phone
Status: Recruiting
Springdale, Arkansas, 72762, United States
No email / No phone
Status: Recruiting
Glendale, California, 91204, United States
No email / No phone
Status: Recruiting
Duarte, California, 91010, United States
No email / No phone
Status: Withdrawn
Sacramento, California, 95817, United States
No email / No phone
Status: Recruiting
Santa Rosa, California, 95403, United States
No email / No phone
Status: Recruiting
Aurora, Colorado, 80012, United States
No email / No phone
Status: Recruiting
New Haven, Connecticut, 06510, United States
No email / No phone
Status: Recruiting
Miami, Florida, 33176, United States
No email / No phone
Status: Recruiting
Plantation, Florida, 33324, United States
No email / No phone
Status: Recruiting
Jacksonville, Florida, 32256, United States
No email / No phone
Status: Recruiting
Palm Bay, Florida, 32909, United States
No email / No phone
Status: Withdrawn
Atlanta, Georgia, 30318, United States
No email / No phone
Status: SUSPENDED
Honolulu, Hawaii, 96819, United States
No email / No phone
Status: Recruiting
Chicago, Illinois, 60637, United States
No email / No phone
Status: Recruiting
Naperville, Illinois, 60540, United States
No email / No phone
Status: Recruiting
Elmhurst, Illinois, 60126, United States
No email / No phone
Status: Recruiting
Decatur, Illinois, 62526, United States
No email / No phone
Status: Withdrawn
New Albany, Indiana, 47150, United States
No email / No phone
Status: Recruiting
Des Moines, Iowa, 50309, United States
No email / No phone
Status: Recruiting
Louisville, Kentucky, 40202, United States
No email / No phone
Status: Recruiting
Lexington, Kentucky, 40503, United States
No email / No phone
Status: Recruiting
Louisville, Kentucky, 40202, United States
No email / No phone
Status: Withdrawn
Louisville, Kentucky, 40207, United States
No email / No phone
Status: Recruiting
Baton Rouge, Louisiana, 70809, United States
No email / No phone
Status: Recruiting
Baton Rouge, Louisiana, 70808, United States
No email / No phone
Status: Recruiting
Baltimore, Maryland, 21215, United States
No email / No phone
Status: Recruiting
Columbia, Maryland, 21044, United States
No email / No phone
Status: Recruiting
Boston, Massachusetts, 02111, United States
No email / No phone
Status: Withdrawn
Worcester, Massachusetts, 01655, United States
No email / No phone
Status: Withdrawn
Grand Rapids, Michigan, 49503, United States
No email / No phone
Status: Recruiting
Detroit, Michigan, 48201, United States
No email / No phone
Status: Recruiting
Saint Paul, Minnesota, 55109, United States
No email / No phone
Status: Recruiting
Hattiesburg, Mississippi, 39401, United States
No email / No phone
Status: Withdrawn
Saint Louis, Missouri, 63129, United States
No email / No phone
Status: Recruiting
Albuquerque, New Mexico, 87109, United States
No email / No phone
Status: Recruiting
Albany, New York, 12206, United States
No email / No phone
Status: Recruiting
New York, New York, 10065, United States
No email / No phone
Status: Recruiting
Stony Brook, New York, 11794-7263, United States
No email / No phone
Status: Recruiting
Cincinnati, Ohio, 45219, United States
No email / No phone
Status: Recruiting
Cleveland, Ohio, 44195, United States
No email / No phone
Status: Recruiting
Cincinnati, Ohio, 45245, United States
No email / No phone
Status: Recruiting
York, Pennsylvania, 17403, United States
No email / No phone
Status: Withdrawn
Providence, Rhode Island, 02903, United States
No email / No phone
Status: Recruiting
Nashville, Tennessee, 37203, United States
No email / No phone
Status: Recruiting
Chattanooga, Tennessee, 37404, United States
No email / No phone
Status: Recruiting
El Paso, Texas, 79902, United States
No email / No phone
Status: Recruiting
Flower Mound, Texas, 75028, United States
No email / No phone
Status: Recruiting
Fort Worth, Texas, 76104, United States
No email / No phone
Status: Recruiting
Houston, Texas, 77054, United States
No email / No phone
Status: Withdrawn
Houston, Texas, 77098, United States
No email / No phone
Status: Withdrawn
Houston, Texas, 77090, United States
No email / No phone
Status: Recruiting
Kingwood, Texas, 77339, United States
No email / No phone
Status: Withdrawn
McKinney, Texas, 75071, United States
No email / No phone
Status: Withdrawn
Sugar Land, Texas, 77479, United States
No email / No phone
Status: Recruiting
Dallas, Texas, 75230, United States
No email / No phone
Status: Withdrawn
Dallas, Texas, 75246, United States
No email / No phone
Status: Recruiting
Dallas, Texas, 75246, United States
No email / No phone
Status: Withdrawn
Norfolk, Virginia, 23502, United States
No email / No phone
Status: Recruiting
Fairfax, Virginia, 22031, United States
No email / No phone
Status: Not yet recruiting
Charlottesville, Virginia, 22903, United States
No email / No phone
Status: Recruiting
Roanoke, Virginia, 24014, United States
No email / No phone
Status: Recruiting
Midlothian, Virginia, 23114, United States
No email / No phone
Status: Recruiting
Tacoma, Washington, 98405, United States
No email / No phone
Status: Recruiting
Madison, Wisconsin, 53792, United States
No email / No phone
Status: Recruiting
Ho Chi Minh City, 700000, Vietnam
No email / No phone
Status: Recruiting
Vinh, 460000, Vietnam
No email / No phone
Status: Recruiting
Hanoi, 100000, Vietnam
No email / No phone
Status: Recruiting