Sponsor: Seagen Inc. (industry)
Phase: 3
Start date: Feb. 21, 2024
Planned enrollment: 600
Last updated in HealthScout: Dec 2024
Sigvotatug vedotin (SV), also known as SGN-B6A, is an investigational antibody-drug conjugate (ADC) targeting integrin beta-6 (ITGB6), a protein implicated in tumor progression and associated with poor outcomes in various cancers, including non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), and esophageal cancer (EC). (ascopubs.org)
SV comprises an antibody directed against ITGB6 linked to monomethyl auristatin E (MMAE), a cytotoxic agent. Upon binding to ITGB6-expressing tumor cells, SV is internalized, releasing MMAE to disrupt microtubule networks, leading to cell death. Additionally, SV induces immunogenic cell death, promoting immune cell activation and recruitment to the tumor microenvironment. (aacrjournals.org)
In a Phase 1 study (SGNB6A-001), SV demonstrated antitumor activity in patients with advanced solid tumors. Among 113 NSCLC patients, the confirmed objective response rate (cORR) was 19.5% (95% CI, 12.6–28.0). Notably, in non-squamous, taxane-naive NSCLC patients, the cORR was 32.5% (95% CI, 18.6–49.1). (ascopubs.org)
SV exhibited a manageable safety profile. Treatment-emergent adverse events (TEAEs) occurred in 98.2% of NSCLC patients, with 46.0% experiencing Grade ≥3 TEAEs. Common Grade ≥3 TEAEs included dyspnea (9.7%), fatigue (7.1%), and neutropenia (5.3%). One treatment-related death due to pneumonitis was reported. (ascopubs.org)
Last updated: Apr 2025
Last updated: Apr 2025
Goal: The primary goal of this clinical trial is to determine whether the investigational drug sigvotatug vedotin offers a superior therapeutic advantage over the standard chemotherapy agent docetaxel in treating previously treated adult patients with nonsquamous non-small cell lung cancer (NSCLC). The trial seeks to assess both the effectiveness and safety of these interventions.
Patients: The trial targets adult patients with confirmed locally advanced, unresectable or metastatic nonsquamous non-small cell lung cancer (NSCLC). Eligible participants have previously been treated with a platinum-based chemotherapy regimen and anti-PD-(L)1 agents, with specific eligibility criteria for those with tumors exhibiting actionable genomic alterations.
Design: This is a randomized, Phase 3 open-label trial with an intended enrollment of 600 participants allocated to either the investigational or control arm.
Treatments: Participants in the experimental arm receive sigvotatug vedotin, an antibody-drug conjugate targeting integrin beta-6, a protein prevalent in various solid tumors. This ADC consists of a monoclonal antibody linked to monomethyl auristatin E (MMAE), which interrupts tumor cells' microtubules, thereby inducing cytotoxicity and promoting immune cell recruitment. Preliminary Phase 1 results noted significant anti-tumor activity in several cancers, including NSCLC. The control arm applies docetaxel, a well-established chemotherapy used in NSCLC treatment.
Outcomes: Primary outcomes include overall survival and confirmed objective response rate according to RECIST v1.1. Secondary outcomes encompass progression-free survival, duration of response, adverse event rates, and quality of life measures spanning a 5-year timeline.
Burden on patient: The trial imposes moderate to low burden on participants. While it necessitates adherence to a regular infusion schedule (sigvotatug vedotin bi-monthly or docetaxel every three weeks), the requirements align closely with typical NSCLC treatment schedules. Routine monitoring via imaging and laboratory tests is anticipated, similar to standard care, minimizing additional burden beyond standard oncologic practices. No additional biopsies or excessive travel demands are indicated.
Inclusion Criteria:
* Histologically or cytologically confirmed diagnosis of locally advanced, unresectable (Stage IIIB, IIIC), or metastatic Stage IV (M1a, M1b, or M1c) NSCLC American Joint Committee on Cancer (AJCC) Staging Manual, Version 8.0, and the Union for International Cancer Control (UICC) Staging System (Eighth edition).
* Participants must have NSCLC with nonsquamous histology
* Tumors with squamous, or predominantly squamous histology are excluded.
* Tumors with small cell elements are excluded.
* Participants who have NSCLC with known actionable genomic alteration (AGAs) are permitted
* Participants must have received the following prior therapies and progressed during or relapsed after receiving their most recent prior therapy:
* Participants with no known AGAs must fulfill 1 of the following conditions:
* Received a platinum-based combination therapy for the treatment of metastatic or recurrent disease and a PD-(L)1 monoclonal antibody (concurrently or sequentially with platinum-based chemotherapy), unless contraindicated.
* Experienced disease progression within 6 months of the last dose of platinum-based chemotherapy in the adjuvant or neoadjuvant setting and received a PD-(L)1 monoclonal antibody at any time during the course of treatment.
* Participants with known AGAs must fulfill the following conditions:
* Must have received at least 1 relevant AGA targeted therapy and in the opinion of the investigator, additional AGA targeted therapy is not in the best interest of the participant.
* Received a platinum-based combination therapy for the treatment of metastatic or recurrent disease, or experienced disease progression within 6 months of the last dose of platinum-based chemotherapy in the adjuvant or neoadjuvant setting
* May have received up to 1 PD-(L)1 monoclonal antibody (concurrently or sequentially with platinum-based chemotherapy).
* Measurable disease based on RECIST v1.1
* Participants must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1, with adequate baseline hematologic, hepatic, and renal function and measurable disease according to RECIST v1.1
Exclusion Criteria:
* Life expectancy of less than (\<) 3 months
* Known allergies/hypersensitivity/intolerance to or contraindication of taxanes, docetaxel, or any excipient contained in the drug formulation of sigvotatug vedotin
* History of another malignancy within 3 years before Cycle 1 Day 1, or any evidence of residual disease from a previously diagnosed malignancy. Exceptions are malignancies with a negligible risk of metastasis or death
* Participants with any of the following respiratory conditions:
* Evidence of noninfectious interstitial lung disease (ILD) or pneumonitis that:
* Was previous diagnosed and required systemic steroids, or
* Is currently diagnosed and managed, or
* Is suspected on radiologic imaging at screening
* Known diffusing capacity of the lung for carbon monoxide (DLCO) \< 50%
* Any Grade greater than or equal to (≥) 3 pulmonary disease unrelated to underlying malignancy
* Pre-existing peripheral neuropathy Grade greater than or equal to (≥) 2
* Uncontrolled diabetes mellitus
* Prior therapy:
* Prior treatment with antimicrotubule agents (taxanes, vinca alkaloids, or MMAEs) in the locally advanced, unresectable/refractory, or metastatic setting
* Prior antimicrotubule agent exposure in curative settings (including adjuvant, neoadjuvant, or chemoradiotherapy) is permissible.
* Received more than 1 prior line of cytotoxic chemotherapy in the locally advanced, unresectable/refractory, or metastatic setting
* Prior cytotoxic chemotherapy in curative settings is permissible
* At least 14 days must have elapsed from the last dose of radiotherapy until Cycle 1 Day 1.
* Prior radiation therapy to the lung parenchyma that is \>30 Gray (Gy) within 6 months of Cycle 1 Day 1.
* Any systemic anticancer therapy (standard or experimental) within 21 days prior to Cycle 1 Day 1.
* Active central nervous system (CNS) lesions, including leptomeningeal metastasis, are excluded. Participants with definitively treated brain metastases are eligible in they meet the following criteria:
* Have been clinically stable for at least 4 weeks prior to treatment initiation and baseline scans show no evidence of new or enlarged metastasis
* On a stable dose of less than or equal to (≤) 10mg/day of prednisone or equivalent for a least 2 weeks (if requiring steroid treatment)
* Treatment with corticosteroids greater than (\>) 1 month prior to Screening visit
* No evidence of clinical and radiographic disease progression in the CNS for ≥ 21 days after definitive radiotherapy and/or surgery
Mar del Plata, B7600FZO, Argentina
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Rosario, S2000KZE, Argentina
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San Juan, J5400, Argentina
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Rosario, S2002KDS, Argentina
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Rosario, S2000DSV, Argentina
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Cordoba, X5008HHW, Argentina
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Cordoba, X5021FPQ, Argentina
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Albury, New South Wales, 2640, Australia
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Waratah, New South Wales, 2298, Australia
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Kingswood, New South Wales, 2747, Australia
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Albury, New South Wales, 2640, Australia
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Murdoch, Other, 6150, Australia
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Woolloongabba, Queensland, 4102, Australia
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Melbourne, Victoria, 3004, Australia
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Murdoch, Western Australia, 6150, Australia
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Frankston, 3199, Australia
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Graz, A-8010, Austria
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Graz, 8036, Austria
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Graz, 8036, Austria
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Graz, 8036, Austria
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Graz, A-8036, Austria
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Vienna, 1090, Austria
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Wien, A-1020, Austria
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Brasschaat, 2930, Belgium
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Edegem, 2650, Belgium
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Ghent, 9000, Belgium
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Hasselt, 3500, Belgium
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Liege, 4000, Belgium
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Jaú, SAO Paulo, 17210-120, Brazil
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Santo Andre, SAO Paulo, 09060-650, Brazil
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Vila Olímpia, SAO Paulo, 04538-132, Brazil
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Barretos, 14784-400, Brazil
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Fortaleza, 60336-045, Brazil
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Ijui, 98700-000, Brazil
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Porto Alegre, 90110-270, Brazil
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Porto Alegre, 90610-000, Brazil
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Salvador, 40170-110, Brazil
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Calgary, Alberta, T2N 5G2, Canada
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Edmonton, Alberta, T6G 1Z2, Canada
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Brampton, Ontario, L6R 3J7, Canada
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Etobicoke, Ontario, M9V 1 R8, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Toronto, Ontario, M4N 3M5, Canada
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Greenfield Park, Quebec, J4V 2H1, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Santiago, Region Metropolitana, 8331143, Chile
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Providencia, Santiago, Chile
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Vina del Mar, Valparaíso, 25240364, Chile
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Concepción, 4070268, Chile
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Santiago, 13127, Chile
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Hefei, Anhui, 230022, China
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Fuzhou, Fujian, 350014, China
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Foshan, Guangdong, 528000, China
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Guangzhou, Guangdong, 510080, China
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Guangzhou, Guangdong, 510080, China
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Jiangmen City, Guangdong, 529000, China
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Nanning, Guangxi, 530201, China
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Luoyang, Henan, 471003, China
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Zhengzhou, Henan, 450008, China
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Wuhan, Hubei, 430048, China
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Changsha, Hunan, 410013, China
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Nanjing, Jiangsu, 210029, China
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Nanchang, Jiangxi, 330200, China
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Jinan, Shandong, 250117, China
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Linyi, Shandong, 276001, China
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Chengdu, Sichuan, 610213, China
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Taizhou, Zhejiang, 317000, China
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Beijing, 100142, China
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Beijing, 101149, China
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Chongqing, 400030, China
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Shanghai, 200032, China
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Olomouc, 779 00, Czechia
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Ostrava, 70300, Czechia
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Praha 2, 128 08, Czechia
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Villejuif Cedex, Paris, 94805, France
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Toulon, VAR, 83 000, France
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Quimper, 29000, France
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Villejuif, 94805, France
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Toulouse, 31059, France
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Strasbourg, 67200, France
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Rennes Cedex 9, 35033, France
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Pessac, 33604, France
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Paris, 75018, France
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Paris, 75014, France
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Montpellier, 34070, France
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Montpellier, 34070, France
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Marseille, 13015, France
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Lille, 59037, France
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Creteil, 94000, France
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Cholet, 49300, France
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Besancon, 25030, France
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Grosshansdorf, 22927, Germany
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Halle, 06120, Germany
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Bonn, 53113, Germany
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Esslingen, 73730, Germany
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Frankfurt, 60590, Germany
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Gauting, 82131, Germany
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Heidelberg, D-69126, Germany
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Kassel, 34125, Germany
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Luebeck, 23538, Germany
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Luebeck, 23538, Germany
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Muenster, 48149, Germany
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Larissa, Thessaly, 41110, Greece
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Athens, 11526, Greece
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Athens, 11528, Greece
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Athens, 11528, Greece
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Cholargos, 15562, Greece
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N.Faliro, 18547, Greece
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Patras, 26504, Greece
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Pilea, 555 35, Greece
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Thessaloniki, 55236, Greece
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Budapest, 1068, Hungary
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Budapest, 1083, Hungary
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Budapest, 1121, Hungary
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Budapest, 1121, Hungary
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Farkasgyepu, 8582, Hungary
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Veszprem, 8200, Hungary
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Tel Aviv, Other, 6423906, Israel
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Jerusalem, 9103102, Israel
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Kfar Saba, 4428164, Israel
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Petah Tikva, 4941492, Israel
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Rehovot, 7661041, Israel
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Roma, Agrigento, 00144, Italy
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Torrette (AN), Ancona, 60126, Italy
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Caserta, Campania, 81100, Italy
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Meldola, Emilia-romagna, 47014, Italy
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Genova, Genoa, 16132, Italy
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Roma, Lazio, 00168, Italy
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Milano, Lombardy, 20132, Italy
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Milano, Lombardy, 20133, Italy
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Monza, MB, 20900, Italy
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Monza, MB, 20900, Italy
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Aviano, Pordenone, 33081, Italy
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Brescia, Province OF Brescia, 25123, Italy
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Roma, Rome, 00144, Italy
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Roma, Rome, 53-00144, Italy
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Catania, Sicily, 95123, Italy
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Catania, 95123, Italy
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Parma, 43126, Italy
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Roma, 00144, Italy
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Rome, 53-00144, Italy
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Nagoya-shi, Aichi, 464-8681, Japan
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Kashiwa-shi, Chiba, 277-8577, Japan
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Matsuyama-shi, Ehime, 791-0280, Japan
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Kurume, Fukuoka, 830-0011, Japan
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Kobe-shi, Hyōgo, 650-0047, Japan
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Kanazawa-shi, Ishikawa, 920-8641, Japan
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Yokohama, Kanagawa, 241-8515, Japan
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Niigata-shi, Niigata, 951-8566, Japan
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Osakasayama, Osaka, 589-8511, Japan
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Takatsuki-shi, Osaka, 569-8686, Japan
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Osaka, Other, 541-8567, Japan
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Sunto-gun, Shizuoka, 411-8777, Japan
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Bunkyo-ku, Tokyo, 113-8603, Japan
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Bunkyo-ku, Tokyo, 113-8677, Japan
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Chuo-ku, Tokyo, 104-0045, Japan
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Koto-ku, Tokyo, 135-8550, Japan
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Ota-shi, Tokyo, 373-8550, Japan
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Ciudad De México. México., México, C.P. 06100., Mexico
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Monterrey, Nuevo LEÓN, 64320, Mexico
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Ciudad de Mexico, 03100, Mexico
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Cdmx, 03103, Mexico
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Oaxaca de juarez, 68020, Mexico
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Rotterdam, 3015 GD, Netherlands
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Groningen, 9728, Netherlands
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Maastricht, 6229 HX, Netherlands
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Oslo, 0379, Norway
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Oslo, 0379, Norway
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Trondheim, 7030, Norway
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Drammen, 3004, Norway
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GdaDsk, Other, 80-214, Poland
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Lublin, 20-609, Poland
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Poznan, 60-693, Poland
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Lodz, 90-302, Poland
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Cluj-Napoca, Koblenz, 400015, Romania
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Timisoara, 300166, Romania
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Bucuresti, 030463, Romania
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Bucuresti, Romania
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Cluj-Napoca, 400641, Romania
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Constanta, 905900, Romania
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Craiova, 200745, Romania
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Alicante, Comunidad Valenciana, 03010, Spain
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Palma, Islas Baleares, 07120, Spain
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Barcelona, Other, 08029, Spain
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Badalona, 08919, Spain
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Barcelona, 08035, Spain
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Castello de la Plana, 12002, Spain
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Madrid, 28007, Spain
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Madrid, 28040, Spain
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Madrid, 28041, Spain
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Malaga, 129004, Spain
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Valencia, 46009, Spain
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Zaragoza, 50009, Spain
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A Coruna, 15009, Spain
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Alicante, 03010, Spain
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Valencia, 46026, Spain
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Chur, Graubünden (DE), 07000, Switzerland
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Chur, Other, 7000, Switzerland
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Bern, 3010, Switzerland
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Zurich, CH-8091, Switzerland
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Zurich, 8091, Switzerland
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Zurich, 8091, Switzerland
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Lausanne, 1011, Switzerland
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Chur, 7000, Switzerland
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Basel, 4031, Switzerland
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Douliou City, Other, 640, Taiwan
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Taipei, 11217, Taiwan
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Kaohsiung, 82445, Taiwan
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Changhua, 500, Taiwan
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Kaohsiung, 807, Taiwan
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Manchester, NEW Hampshire, M20 4GJ, United Kingdom
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London, Other, W1G 8BJ, United Kingdom
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London, Others, W1G 7AF, United Kingdom
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London, W1G 8PP, United Kingdom
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Sutton, SM2 5PT, United Kingdom
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Sutton, SM2 5PT, United Kingdom
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Glasgow, G12 0YN, United Kingdom
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Leeds, LS9 7TF, United Kingdom
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London, EC1A 7BE, United Kingdom
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London, SW3 6JJ, United Kingdom
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London, SW3 6JJ, United Kingdom
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London, W1G 6AD, United Kingdom
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London, W1G 7LJ, United Kingdom
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Birmingham, Alabama, 35205, United States
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Alabaster, Alabama, 35007, United States
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Bessemer, Alabama, 35055, United States
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Birmingham, Alabama, 35209, United States
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Birmingham, Alabama, 35211, United States
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Birmingham, Alabama, 35243, United States
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Anchorage, Alaska, 99508, United States
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Goodyear, Arizona, 85395, United States
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Prescott, Arizona, 86301, United States
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Fullerton, California, 92835, United States
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Status: Recruiting
Los Alamitos, California, 90720, United States
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Status: Recruiting
Los Alamitos, California, 90720, United States
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Status: Recruiting
Los Angeles, California, 90024, United States
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Status: Recruiting
Los Angeles, California, 90095, United States
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Status: Recruiting
Orange, California, 92868, United States
No email / No phone
Status: Not yet recruiting
Orange, California, 92868, United States
No email / No phone
Status: Not yet recruiting
Orange, California, 92868, United States
No email / No phone
Status: Not yet recruiting
Orange, California, 92868, United States
No email / No phone
Status: Not yet recruiting
San Francisco, California, 94158, United States
No email / No phone
Status: Recruiting
Solvang, California, 93463, United States
No email / No phone
Status: Not yet recruiting
Santa Barbara, California, 93105, United States
No email / No phone
Status: Not yet recruiting
Bakersfield, California, 93309, United States
No email / No phone
Status: Not yet recruiting
Fullerton, California, 92835, United States
No email / No phone
Status: Recruiting
Aurora, Colorado, 80012, United States
No email / No phone
Status: Recruiting
Boulder, Colorado, 80303, United States
No email / No phone
Status: Recruiting
Colorado Springs, Colorado, 80907, United States
No email / No phone
Status: Recruiting
Denver, Colorado, 80218, United States
No email / No phone
Status: Recruiting
Denver, Colorado, 80220, United States
No email / No phone
Status: Recruiting
Lakewood, Colorado, 80228, United States
No email / No phone
Status: Recruiting
Littleton, Colorado, 80120, United States
No email / No phone
Status: Recruiting
Lone Tree, Colorado, 80124, United States
No email / No phone
Status: Recruiting
Longmont, Colorado, 80504, United States
No email / No phone
Status: Recruiting
Pueblo, Colorado, 81003, United States
No email / No phone
Status: Recruiting
Waterbury, Connecticut, 06708, United States
No email / No phone
Status: Recruiting
Derby, Connecticut, 06418, United States
No email / No phone
Status: Recruiting
Fairfield, Connecticut, 06824, United States
No email / No phone
Status: Recruiting
Glastonbury, Connecticut, 06033, United States
No email / No phone
Status: Recruiting
Greenwich, Connecticut, 06830, United States
No email / No phone
Status: Recruiting
Guilford, Connecticut, 06437, United States
No email / No phone
Status: Recruiting
Hartford, Connecticut, 06105, United States
No email / No phone
Status: Recruiting
New Haven, Connecticut, 06510, United States
No email / No phone
Status: Recruiting
New Haven, Connecticut, 06510, United States
No email / No phone
Status: Recruiting
North Haven, Connecticut, 06473, United States
No email / No phone
Status: Recruiting
Torrington, Connecticut, 06790, United States
No email / No phone
Status: Recruiting
Trumbull, Connecticut, 06611, United States
No email / No phone
Status: Recruiting
Waterford, Connecticut, 06385, United States
No email / No phone
Status: Recruiting
Rockledge, Florida, 32955, United States
No email / No phone
Status: Recruiting
Melbourne, Florida, 32935, United States
No email / No phone
Status: Recruiting
Miami, Florida, 33176, United States
No email / No phone
Status: Not yet recruiting
Palm Bay, Florida, 32901, United States
No email / No phone
Status: Recruiting
Jacksonville, Florida, 32256, United States
No email / No phone
Status: Recruiting
Niles, Illinois, 60714, United States
No email / No phone
Status: Not yet recruiting
Arlington Heights, Illinois, 60005, United States
No email / No phone
Status: Not yet recruiting
Columbia, Maryland, 21044, United States
No email / No phone
Status: Recruiting
Fairhaven, Massachusetts, 02719, United States
No email / No phone
Status: Recruiting
Fall River, Massachusetts, 02720, United States
No email / No phone
Status: Recruiting
Boston, Massachusetts, 02215, United States
No email / No phone
Status: Recruiting
Boston, Massachusetts, 02118, United States
No email / No phone
Status: Not yet recruiting
Woodbury, Minnesota, 55125, United States
No email / No phone
Status: Not yet recruiting
Burnsville, Minnesota, 55337, United States
No email / No phone
Status: Not yet recruiting
Chaska, Minnesota, 55318, United States
No email / No phone
Status: Not yet recruiting
Coon Rapids, Minnesota, 55433, United States
No email / No phone
Status: Recruiting
Coon Rapids, Minnesota, 55433, United States
No email / No phone
Status: Not yet recruiting
Edina, Minnesota, 55435, United States
No email / No phone
Status: Recruiting
Fridley, Minnesota, 55432, United States
No email / No phone
Status: Not yet recruiting
Maple Grove, Minnesota, 55369, United States
No email / No phone
Status: Not yet recruiting
Maplewood, Minnesota, 55109, United States
No email / No phone
Status: Recruiting
Minneapolis, Minnesota, 55404, United States
No email / No phone
Status: Not yet recruiting
Minneapolis, Minnesota, 55407, United States
No email / No phone
Status: Recruiting
Minneapolis, Minnesota, 55415, United States
No email / No phone
Status: Recruiting
Plymouth, Minnesota, 55441, United States
No email / No phone
Status: Not yet recruiting
Robbinsdale, Minnesota, 55422, United States
No email / No phone
Status: Recruiting
Saint Louis Park, Minnesota, 55426, United States
No email / No phone
Status: Recruiting
Saint Paul, Minnesota, 55101, United States
No email / No phone
Status: Recruiting
Saint Paul, Minnesota, 55102, United States
No email / No phone
Status: Recruiting
Hattiesburg, Mississippi, 39401, United States
No email / No phone
Status: Recruiting
Kansas City, Missouri, 64111, United States
No email / No phone
Status: ACTIVE_NOT_RECRUITING
Omaha, Nebraska, 68198, United States
No email / No phone
Status: Recruiting
Omaha, Nebraska, 68198, United States
No email / No phone
Status: Recruiting
Las Vegas, Nevada, 89144, United States
No email / No phone
Status: Recruiting
Henderson, Nevada, 89052, United States
No email / No phone
Status: Recruiting
Henderson, Nevada, 89074, United States
No email / No phone
Status: Recruiting
Las Vegas, Nevada, 89128, United States
No email / No phone
Status: Recruiting
Las Vegas, Nevada, 89148, United States
No email / No phone
Status: Recruiting
Las Vegas, Nevada, 89169, United States
No email / No phone
Status: Recruiting
Florham Park, New Jersey, 07932, United States
No email / No phone
Status: Recruiting
Berkeley Heights, New Jersey, 07922, United States
No email / No phone
Status: Recruiting
Clifton, New Jersey, 07013, United States
No email / No phone
Status: Recruiting
Albuquerque, New Mexico, 87106, United States
No email / No phone
Status: Recruiting
Albuquerque, New Mexico, 87131, United States
No email / No phone
Status: Recruiting
New York, New York, 10016, United States
No email / No phone
Status: Not yet recruiting
Mineola, New York, 11501, United States
No email / No phone
Status: Not yet recruiting
New York, New York, 10016, United States
No email / No phone
Status: Not yet recruiting
New York, New York, 10016, United States
No email / No phone
Status: Not yet recruiting
Mineola, New York, 11501, United States
No email / No phone
Status: Not yet recruiting
Maumee, Ohio, 43537, United States
No email / No phone
Status: Not yet recruiting
Orange Village, Ohio, 44122, United States
No email / No phone
Status: Recruiting
Mentor, Ohio, 44060, United States
No email / No phone
Status: Recruiting
Mayfield Heights, Ohio, 44124, United States
No email / No phone
Status: Not yet recruiting
Avon, Ohio, 44011, United States
No email / No phone
Status: Recruiting
Cincinnati, Ohio, 45211, United States
No email / No phone
Status: Recruiting
Cincinnati, Ohio, 45236, United States
No email / No phone
Status: Recruiting
Cincinnati, Ohio, 45242, United States
No email / No phone
Status: Recruiting
Cleveland, Ohio, 44106, United States
No email / No phone
Status: Not yet recruiting
Cleveland, Ohio, 44106, United States
No email / No phone
Status: Recruiting
Cleveland, Ohio, 44111, United States
No email / No phone
Status: Not yet recruiting
Cleveland, Ohio, 44195, United States
No email / No phone
Status: Not yet recruiting
Fairfield, Ohio, 45014, United States
No email / No phone
Status: Recruiting
Beaverton, Oregon, 97006, United States
No email / No phone
Status: Recruiting
Eugene, Oregon, 97401, United States
No email / No phone
Status: Recruiting
Gresham, Oregon, 97030, United States
No email / No phone
Status: Recruiting
Portland, Oregon, 97210, United States
No email / No phone
Status: Recruiting
Portland, Oregon, 97216, United States
No email / No phone
Status: Recruiting
Portland, Oregon, 97227, United States
No email / No phone
Status: Recruiting
Portland, Oregon, 97239, United States
No email / No phone
Status: Recruiting
Portland, Oregon, 97239, United States
No email / No phone
Status: Recruiting
Portland, Oregon, 97239, United States
No email / No phone
Status: Recruiting
Tigard, Oregon, 97223, United States
No email / No phone
Status: Recruiting
Tualatin, Oregon, 97062, United States
No email / No phone
Status: Recruiting
Wynnewood, Pennsylvania, 19096, United States
No email / No phone
Status: Recruiting
Bensalem, Pennsylvania, 19020, United States
No email / No phone
Status: Recruiting
Doylestown, Pennsylvania, 18901, United States
No email / No phone
Status: Recruiting
Horsham, Pennsylvania, 19044, United States
No email / No phone
Status: Recruiting
Langhorne, Pennsylvania, 19047, United States
No email / No phone
Status: Recruiting
Media, Pennsylvania, 19063, United States
No email / No phone
Status: Recruiting
Sellersville, Pennsylvania, 18960, United States
No email / No phone
Status: Recruiting
Austin, Texas, 78705, United States
No email / No phone
Status: Recruiting
Abilene, Texas, 79606, United States
No email / No phone
Status: Recruiting
Amarillo, Texas, 79124, United States
No email / No phone
Status: Recruiting
El Paso, Texas, 79938, United States
No email / No phone
Status: Recruiting
Fort Worth, Texas, 76104, United States
No email / No phone
Status: Not yet recruiting
Irving, Texas, 75063, United States
No email / No phone
Status: Not yet recruiting
Midland, Texas, 79701, United States
No email / No phone
Status: Recruiting
Odessa, Texas, 79761, United States
No email / No phone
Status: Recruiting
Pearland, Texas, 77584, United States
No email / No phone
Status: Recruiting
Richardson, Texas, 75080, United States
No email / No phone
Status: Not yet recruiting
Tyler, Texas, 75701, United States
No email / No phone
Status: Recruiting
Tyler, Texas, 75708, United States
No email / No phone
Status: Recruiting
Waco, Texas, 76712, United States
No email / No phone
Status: Recruiting
Wichita Falls, Texas, 76310, United States
No email / No phone
Status: Recruiting
Austin, Texas, 78731, United States
No email / No phone
Status: Recruiting
Austin, Texas, 78745, United States
No email / No phone
Status: Recruiting
Dallas, Texas, 75235, United States
No email / No phone
Status: Not yet recruiting
Dallas, Texas, 75235, United States
No email / No phone
Status: Not yet recruiting
Dallas, Texas, 75237, United States
No email / No phone
Status: Not yet recruiting
Dallas, Texas, 75390, United States
No email / No phone
Status: Not yet recruiting
Dallas, Texas, 75390, United States
No email / No phone
Status: Not yet recruiting
Dallas, Texas, 75390, United States
No email / No phone
Status: Not yet recruiting
El Paso, Texas, 79902, United States
No email / No phone
Status: Recruiting
El Paso, Texas, 79915, United States
No email / No phone
Status: Recruiting
Wytheville, Virginia, 24382, United States
No email / No phone
Status: Not yet recruiting
Salem, Virginia, 24153, United States
No email / No phone
Status: Not yet recruiting
Puyallup, Washington, 98373, United States
No email / No phone
Status: Not yet recruiting
Vancouver, Washington, 98684, United States
No email / No phone
Status: Recruiting
Tacoma, Washington, 98405, United States
No email / No phone
Status: Not yet recruiting
Bonney Lake, Washington, 98391, United States
No email / No phone
Status: Not yet recruiting
Federal Way, Washington, 98003, United States
No email / No phone
Status: Not yet recruiting
Gig Harbor, Washington, 98332, United States
No email / No phone
Status: Not yet recruiting
Olympia, Washington, 98502, United States
No email / No phone
Status: Not yet recruiting
Olympia, Washington, 98506, United States
No email / No phone
Status: Not yet recruiting
Milwaukee, Wisconsin, 53226, United States
No email / No phone
Status: Not yet recruiting