Sponsor: Seagen, a wholly owned subsidiary of Pfizer (industry)
Phase: 3
Start date: Sept. 22, 2023
Planned enrollment: 400
Disitamab vedotin (DV; RC48; Aidixi) is a HER2‑directed antibody–drug conjugate (ADC) consisting of the humanized anti‑HER2 antibody hertuzumab linked via a protease‑cleavable mc‑val‑cit‑PABC linker to the microtubule inhibitor monomethyl auristatin E (MMAE). It has shown antitumor activity across multiple HER2‑expressing solid tumors, including urothelial, gastric/gastroesophageal junction (G/GEJ), and breast cancers. DV received its first approval in China in June 2021 for previously treated HER2‑overexpressing G/GEJ cancer. (pmc.ncbi.nlm.nih.gov)
Urothelial carcinoma (UC)
- Phase II pooled analysis (RC48‑C005/C009; HER2‑positive la/mUC after ≥1 prior systemic therapy; n=107):
- ORR 50.5% (95% CI 40.6–60.3) by blinded independent review; median DoR 7.3 months; median PFS 5.9 months; median OS 14.2 months. Activity was seen across subgroups, including those with liver metastases and prior PD‑1/L1 therapy. (pubmed.ncbi.nlm.nih.gov)
- Phase Ib/II combination with toripalimab (RC48‑C014; HER2‑unselected la/mUC; n=41; RP2D DV 2.0 mg/kg q2w + toripalimab 3 mg/kg q2w):
- Confirmed ORR 73.2%; median PFS 9.3 months; median OS 33.1 months (data cutoff March 1, 2024). (pubmed.ncbi.nlm.nih.gov)
- Additional real‑world/retrospective data suggest clinically meaningful activity of DV plus PD‑1 inhibitors in metastatic upper tract UC, with ORR ~59% and median PFS ~13 months (limitations: retrospective design, China‑only cohorts). (pubmed.ncbi.nlm.nih.gov)
Gastric/gastroesophageal junction (G/GEJ) cancer - DV received its first approval in China (June 2021) for previously treated HER2‑overexpressing G/GEJ cancer. (pubmed.ncbi.nlm.nih.gov) - Early‑phase combination studies of DV with PD‑1 inhibitors have reported encouraging activity in HER2‑expressing G/GEJ disease (dose‑escalation/expansion study with toripalimab established RP2D of DV 2.5 mg/kg + toripalimab 3 mg/kg q2w; preliminary efficacy reported). (pubmed.ncbi.nlm.nih.gov) - A multicenter real‑world third‑line‑and‑beyond cohort showed higher ORR and longer PFS with DV plus immune checkpoint inhibitors versus DV alone in HER2‑positive or HER2‑low G/GEJ cancer (ORR 36% vs 10%; median PFS 6.2 vs 3.9 months). (bmccancer.biomedcentral.com)
Breast cancer - Phase I/Ib pooled analysis in advanced breast cancer (HER2‑overexpressing and HER2‑low): at the 2.0 mg/kg q2w dose, confirmed ORR was 42.9% in HER2‑overexpressing and 33.3% in HER2‑low cohorts; median PFS 5.7 and 5.1 months, respectively. (onlinelibrary.wiley.com) - Retrospective real‑world series in previously trastuzumab‑treated metastatic HER2‑positive disease reported ORR 29.6% and median real‑world PFS 5.9 months. (pubmed.ncbi.nlm.nih.gov)
Across trials, the most frequent treatment‑related adverse events (TRAEs) include peripheral sensory neuropathy, hematologic toxicity (neutropenia, leukopenia), and transaminase elevations—generally consistent with MMAE‑based ADCs. In the pooled phase II UC analysis, any‑grade peripheral sensory neuropathy occurred in 68.2% (grade ≥3 in 18.7%); leukopenia in 50.5%; neutropenia in 42.1%. (pubmed.ncbi.nlm.nih.gov)
With DV plus toripalimab in la/mUC (RC48‑C014), common TRAEs were AST increased (65.9%), ALT increased (63.4%), and peripheral sensory neuropathy (63.4%); grade ≥3 TRAEs occurred in 51.2%, and one treatment‑related death (pneumonitis) was reported. (pubmed.ncbi.nlm.nih.gov)
In the phase I/Ib breast cancer program, grade ≥3 events ≥5% included decreased neutrophil count (17.6%), GGT increased (13.2%), asthenia (11.0%), decreased WBC (9.6%); neuropathy events were observed but severe neurotoxicity was uncommon. (onlinelibrary.wiley.com)
Notes: Multiple phase 2/3 programs evaluating DV combinations (often with PD‑1 inhibitors) in UC and G/GEJ cancer are ongoing; emerging data should be interpreted with typical caveats for single‑arm and/or retrospective studies. (pubmed.ncbi.nlm.nih.gov)
Last updated: Oct 2025
Goal: To determine whether disitamab vedotin combined with pembrolizumab improves progression-free survival and overall survival compared with platinum-based chemotherapy as first-line treatment for HER2-expressing (IHC ≥1+) locally advanced or metastatic urothelial carcinoma, and to characterize safety and patient-reported outcomes.
Patients: Adults with histologically confirmed, unresectable locally advanced or metastatic urothelial carcinoma of the bladder, ureter, renal pelvis, or urethra; HER2 expression by IHC ≥1+; measurable disease per RECIST v1.1; no prior systemic therapy for LA/mUC (allowed if prior neoadjuvant/adjuvant with relapse >12 months); ECOG 0–2; eligible for cisplatin or carboplatin. Key exclusions include active/untreated CNS metastases, significant prior immune-related adverse events to PD-(L)1 therapy, active autoimmune disease requiring systemic therapy, prior HER2-targeted therapy or MMAE-containing agents, prior transplant, and symptomatic effusions/ascites.
Design: Global, open-label, randomized, controlled phase 3 trial with approximately 400 participants allocated to experimental versus standard-of-care chemotherapy arms. Independent blinded central review is used for primary efficacy assessments per RECIST v1.1. Stratification expected by platinum eligibility and HER2 status as per typical UC trials.
Treatments: Experimental: Disitamab vedotin plus pembrolizumab. Disitamab vedotin is an anti-HER2 antibody–drug conjugate comprising a humanized anti-HER2 monoclonal antibody linked via a cleavable vedotin linker to monomethyl auristatin E (MMAE). It targets HER2-expressing cells to deliver MMAE, inducing direct cytotoxicity, bystander killing, immunogenic cell death, and inhibition of HER2 signaling. Early-phase data have shown meaningful activity across HER2-expressing tumors; in urothelial carcinoma, combinations with PD-1 blockade have produced high response rates and manageable toxicity, supporting evaluation in the first-line setting. Pembrolizumab is a PD-1 inhibitor with established efficacy in urothelial carcinoma. Control: Gemcitabine with cisplatin or carboplatin, standard first-line regimens in LA/mUC depending on cisplatin eligibility.
Outcomes: Co-primary endpoints are progression-free survival by blinded independent central review per RECIST v1.1 and overall survival. Key secondary endpoints include objective response rate and duration of response by BICR and investigator assessment, disease control rate, PFS by investigator, safety (adverse events, laboratory and ECG abnormalities, discontinuations due to AEs), cardiac monitoring via LVEF, and patient-reported outcomes including EORTC QLQ-C30 global health status/quality of life and time to pain progression.
Burden on patient: Moderate. Participants require baseline and on-treatment tumor tissue provision, routine imaging for RECIST assessments, and regular clinic visits for infusional therapy: disitamab vedotin every 2 weeks and pembrolizumab every 6 weeks in the experimental arm, or gemcitabine on Days 1 and 8 plus cisplatin or carboplatin every 3 weeks in the control arm. Safety monitoring will involve frequent labs, ECGs, and echocardiograms for LVEF, along with patient-reported outcomes and pain assessments. There are no intensive pharmacokinetic series typical of phase 1 studies, but the need for serial infusions and cardiac monitoring increases visit frequency compared with some maintenance regimens. Overall visit and testing schedules are comparable to standard first-line chemotherapy trials, with additional cardiotoxicity surveillance related to HER2-targeted ADC exposure.
Last updated: Oct 2025
Inclusion Criteria:
* Histopathological confirmation of locally advanced unresectable or metastatic urothelial carcinoma (LA/mUC), including UC originating from the renal pelvis, ureters, bladder, or urethra.
* Measurable disease by investigator assessment per RECIST v1.1.
* Participant must not have received prior systemic therapy for LA/mUC. Exception will be made for neoadjuvant or adjuvant therapy, if disease recurrence/progression occurred more than 12 months after the last dose of therapy.
* Eligible to receive cisplatin- or carboplatin-containing chemotherapy.
* Able to provide archived formalin-fixed paraffin-embedded tumor tissue blocks from a muscle-invasive or metastatic UC lesion or biopsy of metastatic UC prior to treatment initiation. If archival tissue is not available a newly obtained baseline biopsy of an accessible tumor lesion is required within 28 days of cycle 1 day 1.
* HER2 expression of 1+ or greater on immunohistochemistry (IHC).
* Eastern Cooperative Oncology Group (ECOG) performance score of 0, 1, or 2 within 7 days prior to randomization.
Exclusion Criteria:
* Known hypersensitivity to disitamab vedotin, cisplatin, carboplatin, gemcitabine, or pembrolizumab or any of their components.
* History of severe/life threatening immune-related adverse event (irAE) with PD-(L)1 inhibitors are excluded.
* Central nervous system (CNS) and/or leptomeningeal metastasis. Participants with treated CNS metastases are permitted if all of the following are met.
* CNS metastases have been clinically stable for at least 4 weeks and baseline scans show no evidence of new or worsening CNS metastasis.
* Participant is on a stable dose of ≤ 10 mg/day of prednisone or equivalent for at least 2 weeks.
* History of or active autoimmune disease that has required systemic treatment in the past 2 years.
* Prior treatment with an agent directed to another stimulatory or co-inhibitory T cell receptor (including but not limited to CD137 agonists, CAR-T cell therapy, CTLA-4 inhibitors, or OX-40 agonists).
* Prior solid organ or bone marrow transplantation.
* Pleural effusion or ascites with symptoms or requiring symptomatic treatment.
* Estimated life expectancy \<12 week
* Prior treatment with an MMAE agent or anti-HER2 therapy
Viedma, Río Negro Province, 8500, Argentina
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Viedma, Río Negro Province, 8500, Argentina
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Viedma, Río Negro Province, R8500ACE, Argentina
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Buenos Aire, C1019ABS, Argentina
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Buenos Aire, C1280AEB, Argentina
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CABA, 1125, Argentina
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CABA, 1425, Argentina
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Córdoba, X5008HHW, Argentina
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Morón, 1708, Argentina
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Pergamino, B2700CPM, Argentina
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Rosario, 2000, Argentina
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Rosario, 2000, Argentina
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Salta, 4400, Argentina
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San Miguel de Tucumán, Argentina
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Salta, 4400, Argentina
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Berazategui, B1884BBF, Argentina
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Buenos Aires, C1426ANZ, Argentina
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North Ryde, New South Wales, 2109, Australia
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Concord, New South Wales, 2139, Australia
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Darlinghurst, New South Wales, 2010, Australia
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Darlinghurst, New South Wales, 2010, Australia
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Macquarie University, New South Wales, 2109, Australia
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Randwick, New South Wales, 2031, Australia
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St Leonards, New South Wales, 2065, Australia
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South Bribane, Queensland, 4101, Australia
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Brisbane, Queensland, 4101, Australia
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Herston, Queensland, 4029, Australia
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Frankston, Victoria, 3199, Australia
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Melbourne, Victoria, 3084, Australia
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NSW, NSW 2450, Australia
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Port Macquarie, 2444, Australia
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St Leonards, 2065, Australia
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South Brisbane, 4101, Australia
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Caringbah, 2229, Australia
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Elizabeth Vale, 5112, Australia
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Frankston, 3199, Australia
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Malvern, 3144, Australia
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Wilrijk, 2610, Belgium
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Ghent, 9000, Belgium
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Ghent, 9000, Belgium
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Ghent, 9000, Belgium
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Liège, 4000, Belgium
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Namur, 5000, Belgium
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Fortaleza, Ceará, 60810-180, Brazil
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Salvador, Estado de Bahia, 41820-021, Brazil
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Belo Horizonte, Minas Gerais, 30380472, Brazil
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Passo Fundo, Rio Grande do Sul, 99010-080, Brazil
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Porto Alegre, Rio Grande do Sul, 90110-270, Brazil
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Porto Alegre, Rio Grande do Sul, 90610000, Brazil
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Porto Alegre, Rio Grande do Sul, 91350-200, Brazil
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Jaú, São Paulo, 17210080, Brazil
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Rio de Janeiro, 20231-050, Brazil
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Barretos, 14784-400, Brazil
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CuriBba, 81520-060, Brazil
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Rio de Janeiro, 20230-130, Brazil
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São Paulo, 01327-001, Brazil
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Calgary, Alberta, T2N 5G2, Canada
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Edmonton, Alberta, T6G 1Z2, Canada
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Oshawa, Ontario, L1G 2B9, Canada
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Toronto, Ontario, M5G 2M9, Canada
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Santiago, Santiago Metropolitan, 7500994, Chile
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Providencia, Santiago Metropolitan, 7500921, Chile
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Santiago, Santiago Metropolitan, 7510010, Chile
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Santiago, 7500653, Chile
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Viña del Mar, 2540402, Chile
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Hradec Králové, Hradec Králové, 500 05, Czechia
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Olomouc, 779 00, Czechia
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Nice, 06189, France
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Besançon, 25000, France
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Bordeaux, 33076, France
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Caen, 14076, France
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Marseille, 13009, France
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Montpellier, 34298, France
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Montpellier, 34298, France
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Pierre-Bénite, 69310, France
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Strasbourg, 67091, France
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Strasbourg, 67200, France
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Villejuif, 94805, France
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Marousi, Attikí, 151 25, Greece
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Thessaloniki, Kentrikí Makedonía, 546 22, Greece
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Cholargós, 15562, Greece
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Budapest, 1082, Hungary
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Kecskemét, 6000, Hungary
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Surat, Gujarat, 395002, India
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Pune, Maharashtra, 411004, India
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Pune, Maharashtra, 411 004, India
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New Delhi, National Capital Territory of Delhi, 110085, India
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Wilton, T12 DC4A, Ireland
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Tallaght, D24 NR0A, Ireland
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Cork, T12 DC4A, Ireland
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Jerusalem, Other, 91120, Israel
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Ramat Gan, Other, 52621, Israel
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Jerusalem, Other, 9103102, Israel
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Status: Active, not recruiting
Hafia, 3109601, Israel
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Tel Aviv, 6423906, Israel
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Rehovot, 7661041, Israel
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Petah Tikva, 4941492, Israel
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Status: Active, not recruiting
Kefar Sava, 4428164, Israel
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Beersheba, 8410101, Israel
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Afula, 1834111, Israel
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Tricase, Apulia, 73039, Italy
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Bari, Apulia, 70124, Italy
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Ravenna, Emilia-Romagna, 48121, Italy
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Genoa, Liguria, 16132, Italy
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Milan, Lombardy, 20132, Italy
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Rozzano (Milano), Lombardy, 20089, Italy
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Milan, Milan, 20132, Italy
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Rozzano, Milano, 20089, Italy
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Giugliano in Campania, Naples, 80014, Italy
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Bari, Other, 70124, Italy
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Pozzuoli (NA), Other, 80078, Italy
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Aviano, Pordenone, 33081, Italy
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Aviano, Pordenone, 33184, Italy
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Faenza, RA, 48018, Italy
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Lugo, Ravenna, 48022, Italy
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Florence, Tuscany, 50134, Italy
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Terni, Umbria, 05100, Italy
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Verona, 37136, Italy
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Cremona, 26100, Italy
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Florence, 50134, Italy
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Genova, 16132, Italy
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Napoli, 80131, Italy
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Napoli, 80131, Italy
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Status: Not yet recruiting
Padua, 35128, Italy
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Status: Recruiting
Pisa, 56126, Italy
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Status: Recruiting
Pisa, 56126, Italy
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Status: Recruiting
Roma, 00168, Italy
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Status: Recruiting
Verona, 37134, Italy
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Status: Recruiting
Hirosaki, Aomori, 036-8563, Japan
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Status: Not yet recruiting
Tōon, Ehime, 791 -0295, Japan
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Status: Not yet recruiting
Fukuoka, Fukuoka, 811-1395, Japan
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Status: Recruiting
Ota-Shi, Gunma, 373-8550, Japan
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Status: Not yet recruiting
Kobe, Hyōgo, 650-0017, Japan
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Status: Recruiting
Tsukuba, Ibaraki, 305-8576, Japan
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Status: Not yet recruiting
Kita-gun, Kagawa-ken, 761-0793, Japan
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Status: Recruiting
Yokohama, Kanagawa, 232-0024, Japan
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Status: Recruiting
Yokohama, Kanagawa, 241-8515, Japan
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Status: Not yet recruiting
Miyazaki, Miyazaki, 889-1692, Japan
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Status: Not yet recruiting
Kashihara, Nara, 634-8522, Japan
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Status: Not yet recruiting
Osakasayama-Shi, Osaka, 589-8511, Japan
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Status: Not yet recruiting
Suita, Osaka, 565-0871, Japan
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Status: Not yet recruiting
Tokushima, Tokushima, 770-8503, Japan
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Status: Recruiting
Shinjuku-ku, Tokyo, 160-8582, Japan
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Status: Not yet recruiting
Wakayama, Wakayama, 641-8510, Japan
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Status: Not yet recruiting
Ube, Yamaguchi, 755-8505, Japan
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Status: Not yet recruiting
Chiba, 260-8717, Japan
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Status: Not yet recruiting
Kumamoto, 860-0008, Japan
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Status: Recruiting
Osaka, 541-8567, Japan
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Status: Not yet recruiting
Yamagata, 990-9585, Japan
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Status: Not yet recruiting
Breda, North Brabant, 4818 CK, Netherlands
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Status: Not yet recruiting
The Hague, South Holland, 2545 AA, Netherlands
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Status: Recruiting
Amsterdam, 1066 CX, Netherlands
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Status: Not yet recruiting
Amsterdam, 1066 CX, Netherlands
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Status: Not yet recruiting
Arnhem, 6815 AD, Netherlands
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Status: Recruiting
Maastricht, 6229 HX, Netherlands
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Status: Not yet recruiting
Nijmegen, 6525 GA, Netherlands
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Status: Recruiting
Lørenskog, Akershus, N-1478, Norway
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Status: Not yet recruiting
Stavanger, 4011, Norway
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Status: Not yet recruiting
Lima, 15076, Peru
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Lima, 15081, Peru
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Status: Recruiting
Sao Victor, Braga District, 4710-243, Portugal
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Status: Recruiting
Braga, 4710-243, Portugal
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Status: Recruiting
Lisbon, 1400, 038, Portugal
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Status: Recruiting
Lisbon, 1400-038, Portugal
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Status: Recruiting
Lisbon, 1649-028, Portugal
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Status: Recruiting
Porto, 4200-319, Portugal
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Status: Not yet recruiting
Singapore, 168583, Singapore
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Status: Recruiting
Singapore, 188770, Singapore
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Status: Recruiting
Goyang-si, Gyeonggi-do, 10408, South Korea
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Status: Recruiting
Seongnam-si, Gyeonggi-do, 13496, South Korea
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Status: Recruiting
Suwon, Gyeonggi-do, 16247, South Korea
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Status: Recruiting
Jeonju, Jeollabuk-do, 54907, South Korea
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Status: Recruiting
Hwasun-gun, Jeollanam-do, 58128, South Korea
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Status: Recruiting
Iksan-si, Jeonlabuk-do, 54538, South Korea
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Status: Recruiting
Busan, 48108, South Korea
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Status: Recruiting
Busan, 49267, South Korea
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Status: Not yet recruiting
Incheon, 21565, South Korea
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Status: Recruiting
Seongnam-si, 463-707, South Korea
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Status: Recruiting
Seoul, 02841, South Korea
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Status: Recruiting
Seoul, 03181, South Korea
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Status: Recruiting
Seoul, 03722, South Korea
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Status: Recruiting
Seoul, 05505, South Korea
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Status: Recruiting
Santiago de Compostela, A Coruna, 15706, Spain
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Status: Not yet recruiting
Santiago de Compostela, A Coruna, Spain, Spain
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Status: Not yet recruiting
Badalona, Barcelona, 08916, Spain
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Status: Recruiting
Badalona, Barcelona, 08916, Spain
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Status: Recruiting
L'Hospitalet de Llobregat, Barcelona, 08908, Spain
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Status: Recruiting
Barakaldo, Bizkaia, 48903, Spain
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Status: Not yet recruiting
Santander, Cantabria, 39008, Spain
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Status: Recruiting
Majadahonda, Madrid, 28222, Spain
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Status: Recruiting
Badajoz, 06080, Spain
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Status: Not yet recruiting
Badajoz, 06080, Spain
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Status: Not yet recruiting
Barcelona, 08003, Spain
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Status: Recruiting
Barcelona, 08035, Spain
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Status: Recruiting
Barcelona, 08035, Spain
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Status: Recruiting
Barcelona, 08036, Spain
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Status: Recruiting
Barcelona, 08041, Spain
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Status: Recruiting
Barcelona, 08041, Spain
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Status: Recruiting
L'Hospitaler de Llobregat, 08908, Spain
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Status: Recruiting
Las Palmas de Gran Canaria, 35016, Spain
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Status: Recruiting
Madrid, 28007, Spain
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Status: Recruiting
Madrid, 28009, Spain
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Status: Recruiting
Madrid, 28033, Spain
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Status: Recruiting
Madrid, 28034, Spain
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Status: Recruiting
Madrid, 28041, Spain
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Status: Recruiting
Madrid, 28046, Spain
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Status: Recruiting
Madrid, 28046, Spain
No email / No phone
Status: Recruiting
Madrid, 28050, Spain
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Status: Recruiting
Madrid, 28050, Spain
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Status: Recruiting
Ourense, 32005, Spain
No email / No phone
Status: Recruiting
Seville, 41013, Spain
No email / No phone
Status: Recruiting
Valencia, 46014, Spain
No email / No phone
Status: Not yet recruiting
Zaragoza, 50009, Spain
No email / No phone
Status: Recruiting
Stockholm, 171 76, Sweden
No email / No phone
Status: Recruiting
Jönköping, 551 85, Sweden
No email / No phone
Status: Active, not recruiting
Taichung, Taiwan (r.o.c.), 40447, Taiwan
No email / No phone
Status: Recruiting
Taichung, 40447, Taiwan
No email / No phone
Status: Recruiting
Taichung, 40705, Taiwan
No email / No phone
Status: Recruiting
Taichung, 40705, Taiwan
No email / No phone
Status: Recruiting
Tainan City, 704017, Taiwan
No email / No phone
Status: Recruiting
Tainan City, 704, Taiwan
No email / No phone
Status: Recruiting
Taipei, 100, Taiwan
No email / No phone
Status: Recruiting
Taipei, 100, Taiwan
No email / No phone
Status: Recruiting
Tainan City, 73657, Taiwan
No email / No phone
Status: Recruiting
Taoyuan, 33305, Taiwan
No email / No phone
Status: Not yet recruiting
Kaohsiung City, 833401, Taiwan
No email / No phone
Status: Not yet recruiting
Kaohsiung City, 833, Taiwan
No email / No phone
Status: Not yet recruiting
Kaohsiung City, 807, Taiwan
No email / No phone
Status: Recruiting
Taoyuan, 333, Taiwan
No email / No phone
Status: Not yet recruiting
Glasgow, Other, G12 0YN, United Kingdom
No email / No phone
Status: Not yet recruiting
London, EC1A 7BE, United Kingdom
No email / No phone
Status: Recruiting
London, SE1 9RT, United Kingdom
No email / No phone
Status: Not yet recruiting
London, SE1 7EH, United Kingdom
No email / No phone
Status: Not yet recruiting
Gilbert, Arizona, 85234, United States
No email / No phone
Status: Active, not recruiting
Gilbert, Arizona, 85234, United States
No email / No phone
Status: Active, not recruiting
San Francisco, California, 94158, United States
No email / No phone
Status: Recruiting
San Francisco, California, 94158, United States
No email / No phone
Status: Recruiting
San Francisco, California, 94158, United States
No email / No phone
Status: Recruiting
San Francisco, California, 94143, United States
No email / No phone
Status: Recruiting
San Francisco, California, 94143, United States
No email / No phone
Status: Recruiting
San Francisco, California, 94143, United States
No email / No phone
Status: Recruiting
San Francisco, California, 94115, United States
No email / No phone
Status: Recruiting
San Francisco, California, 94115, United States
No email / No phone
Status: Recruiting
San Francisco, California, 94115, United States
No email / No phone
Status: Recruiting
San Francisco, California, 94115, United States
No email / No phone
Status: Recruiting
San Francisco, California, 94107, United States
No email / No phone
Status: Recruiting
Porter Ranch, California, 91326, United States
No email / No phone
Status: Recruiting
Pasadena, California, 91105, United States
No email / No phone
Status: Recruiting
Pasadena, California, 91105, United States
No email / No phone
Status: Recruiting
Newport Beach, California, 92660, United States
No email / No phone
Status: Recruiting
Monterey, California, 93940, United States
No email / No phone
Status: Active, not recruiting
Montecito, California, 93108, United States
No email / No phone
Status: Recruiting
Los Angeles, California, 90095, United States
No email / No phone
Status: Recruiting
Los Angeles, California, 90095, United States
No email / No phone
Status: Recruiting
Los Angeles, California, 90095, United States
No email / No phone
Status: Recruiting
Los Angeles, California, 90095, United States
No email / No phone
Status: Recruiting
Los Angeles, California, 90095, United States
No email / No phone
Status: Recruiting
Los Angeles, California, 90017, United States
No email / No phone
Status: Recruiting
Long Beach, California, 90805, United States
No email / No phone
Status: Recruiting
Glendora, California, 91741, United States
No email / No phone
Status: Recruiting
Glendale, California, 91204, United States
No email / No phone
Status: Recruiting
Encino, California, 91436, United States
No email / No phone
Status: Recruiting
Encino, California, 91436, United States
No email / No phone
Status: Recruiting
Calabasas, California, 91302, United States
No email / No phone
Status: Recruiting
Burbank, California, 91505, United States
No email / No phone
Status: Recruiting
Burbank, California, 91505, United States
No email / No phone
Status: Recruiting
Beverly Hills, California, 90211, United States
No email / No phone
Status: Recruiting
Arcadia, California, 91007, United States
No email / No phone
Status: Recruiting
Alhambra, California, 91801, United States
No email / No phone
Status: Recruiting
Burbank, California, 91505, United States
No email / No phone
Status: Recruiting
Whittier, California, 90602, United States
No email / No phone
Status: Recruiting
Westlake Village, California, 91361, United States
No email / No phone
Status: Recruiting
Ventura, California, 93003, United States
No email / No phone
Status: Recruiting
Valencia, California, 91355, United States
No email / No phone
Status: Recruiting
Torrance, California, 90505, United States
No email / No phone
Status: Recruiting
Torrance, California, 90505, United States
No email / No phone
Status: Recruiting
Thousand Oaks, California, 91360, United States
No email / No phone
Status: Recruiting
Templeton, California, 93455, United States
No email / No phone
Status: Recruiting
Simi Valley, California, 93065, United States
No email / No phone
Status: Recruiting
Santa Monica, California, 90404, United States
No email / No phone
Status: Recruiting
Santa Barbara, California, 93105, United States
No email / No phone
Status: Recruiting
Santa Ana, California, 92705, United States
No email / No phone
Status: Recruiting
San Luis Obispo, California, 93405, United States
No email / No phone
Status: Recruiting
San Luis Obispo, California, 93401, United States
No email / No phone
Status: Recruiting
San Gabriel, California, 91776, United States
No email / No phone
Status: Recruiting
San Gabriel, California, 91776, United States
No email / No phone
Status: Recruiting
San Francisco, California, 94158, United States
No email / No phone
Status: Recruiting
San Francisco, California, 94158, United States
No email / No phone
Status: Recruiting
San Francisco, California, 94158, United States
No email / No phone
Status: Recruiting
San Francisco, California, 94158, United States
No email / No phone
Status: Recruiting
San Francisco, California, 94158, United States
No email / No phone
Status: Recruiting
Baltimore, Maryland, 21204, United States
No email / No phone
Status: Recruiting
Fridley, Minnesota, 55432, United States
No email / No phone
Status: Recruiting
Wyoming, Minnesota, 55092, United States
No email / No phone
Status: Recruiting
Saint Paul, Minnesota, 55101, United States
No email / No phone
Status: Recruiting
Saint Louis Park, Minnesota, 55426, United States
No email / No phone
Status: Recruiting
Minneapolis, Minnesota, 55455, United States
No email / No phone
Status: Recruiting
Minneapolis, Minnesota, 55415, United States
No email / No phone
Status: Recruiting
Minneapolis, Minnesota, 55404, United States
No email / No phone
Status: Recruiting
Maple Grove, Minnesota, 55369, United States
No email / No phone
Status: Recruiting
Edina, Minnesota, 55435, United States
No email / No phone
Status: Recruiting
Edina, Minnesota, 55435, United States
No email / No phone
Status: Recruiting
Burnsville, Minnesota, 55337, United States
No email / No phone
Status: Recruiting
Omaha, Nebraska, 68198, United States
No email / No phone
Status: Recruiting
Bellevue, Nebraska, 68123, United States
No email / No phone
Status: Recruiting
Omaha, Nebraska, 68105, United States
No email / No phone
Status: Recruiting
Omaha, Nebraska, 68118, United States
No email / No phone
Status: Recruiting
Omaha, Nebraska, 68198, United States
No email / No phone
Status: Recruiting
Las Vegas, Nevada, 89102, United States
No email / No phone
Status: Recruiting
Las Vegas, Nevada, 89052, United States
No email / No phone
Status: Recruiting
Las Vegas, Nevada, 89148, United States
No email / No phone
Status: Recruiting
New York, New York, 10029, United States
No email / No phone
Status: Recruiting
New York, New York, 10029, United States
No email / No phone
Status: Recruiting
Greenville, North Carolina, 27834, United States
No email / No phone
Status: Recruiting
Erie, Pennsylvania, 16544, United States
No email / No phone
Status: Recruiting
Pittsburgh, Pennsylvania, 15224, United States
No email / No phone
Status: Recruiting
Pittsburgh, Pennsylvania, 15212, United States
No email / No phone
Status: Recruiting
Pittsburgh, Pennsylvania, 15212, United States
No email / No phone
Status: Recruiting
Natrona Heights, Pennsylvania, 15065, United States
No email / No phone
Status: Recruiting
Monroeville, Pennsylvania, 15146, United States
No email / No phone
Status: Recruiting
Jefferson Hills, Pennsylvania, 15025, United States
No email / No phone
Status: Recruiting
Richardson, Texas, 75080, United States
No email / No phone
Status: Recruiting
Fort Worth, Texas, 76104, United States
No email / No phone
Status: Recruiting
Dallas, Texas, 75390, United States
No email / No phone
Status: Recruiting
Dallas, Texas, 75390, United States
No email / No phone
Status: Recruiting
Dallas, Texas, 75390, United States
No email / No phone
Status: Recruiting
Dallas, Texas, 75237, United States
No email / No phone
Status: Recruiting
Fairfax, Virginia, 22031, United States
No email / No phone
Status: Recruiting
Fairfax, Virginia, 22031, United States
No email / No phone
Status: Recruiting
Seattle, Washington, 98195, United States
No email / No phone
Status: Recruiting
Seattle, Washington, 98104, United States
No email / No phone
Status: Recruiting
Seattle, Washington, 98109, United States
No email / No phone
Status: Recruiting