Trial: Disitamab Vedotin With Pembrolizumab vs…

Trial Details

Sponsor: Seagen, a wholly owned subsidiary of Pfizer (industry)

Phase: 3

Start date: Sept. 22, 2023

Planned enrollment: 400

Trial ID: NCT05911295

More trial details at ClinicalTrials.gov

Show Summary from Sponsor

Investigational Drug AI Analysis

Show for: disitamab vedotin (RC48, Aidixi)

Disitamab vedotin (RC48, Aidixi) is an antibody-drug conjugate (ADC) that targets HER2-expressing cancers. It consists of a humanized anti-HER2 monoclonal antibody (disitamab) conjugated to the cytotoxic agent monomethyl auristatin E (MMAE) via a cleavable vedotin linker [1]. The drug works through multiple mechanisms including direct cytotoxicity to HER2-expressing cells, bystander effect on neighboring cells, immunogenic cell death, and inhibition of HER2 signaling pathways. It received its first approval in China in June 2021 for HER2-overexpressing locally advanced or metastatic gastric cancer after at least two lines of chemotherapy [2].

Clinical Efficacy and Safety

Clinical trials have shown promising results across multiple cancer types. In HER2-expressing metastatic breast cancer, the drug demonstrated objective response rates of 42.9% in HER2-overexpressing and 33.3% in HER2-low disease, with median progression-free survival of 5.7 and 5.1 months respectively [3]. In urothelial carcinoma, when combined with the immunotherapy drug toripalimab, it showed a 73.2% response rate with median progression-free survival of 9.2 months [4]. Common adverse events include elevated liver enzymes, peripheral neuropathy, asthenia, and neutropenia. Grade 3 or higher adverse events occurred in about 40-44% of patients across trials, but were generally manageable.

The drug is currently being investigated in multiple ongoing clinical trials, including phase 3 studies in various cancers. It is being studied both as monotherapy and in combination with other agents like immunotherapy drugs and targeted therapies. Development is focused on both HER2-overexpressing and HER2-low expressing cancers, with studies ongoing in breast cancer, gastric cancer, urothelial cancer, and other solid tumors.

Sources:

[1] AACR Abstract on Mechanism of Action [2] Review Article on Development and Approval [3] Phase I/Ib Study in Breast Cancer [4] Phase 1b/2 Study in Urothelial Cancer

Last updated: Dec 2024

HealthScout AI Analysis

Goal: To determine whether disitamab vedotin combined with pembrolizumab improves progression-free survival and overall survival compared with first-line platinum-based chemotherapy in patients with previously untreated HER2-expressing (IHC ≥1+) locally advanced or metastatic urothelial carcinoma, and to characterize safety and patient-reported outcomes.

Patients: Adults with histologically confirmed, unresectable locally advanced or metastatic urothelial carcinoma of the bladder, ureter, renal pelvis, or urethra; measurable disease by RECIST v1.1; no prior systemic therapy for advanced disease (neoadjuvant/adjuvant permitted if relapse >12 months from last dose); HER2 IHC ≥1+; ECOG 0–2; eligible for cisplatin or carboplatin. Key exclusions include active/untreated CNS metastases, significant prior severe immune-related adverse events, active autoimmune disease requiring systemic therapy, prior anti-HER2 therapy or MMAE-containing ADCs, prior solid organ or bone marrow transplant, and symptomatic effusions/ascites.

Design: Open-label, randomized, active-controlled, phase 3 trial with two parallel arms. Approximately 400 participants randomized to experimental combination therapy versus standard platinum-based chemotherapy. Blinded independent central review is used for primary radiographic endpoints.

Treatments: Experimental: Disitamab vedotin plus pembrolizumab. Disitamab vedotin is an antibody-drug conjugate targeting HER2 that links a humanized anti-HER2 monoclonal antibody to the microtubule-disrupting payload MMAE via a cleavable linker. It exerts activity through direct cytotoxicity in HER2-expressing cells, bystander effect, immunogenic cell death, and inhibition of HER2 signaling. Early-phase studies across HER2-expressing tumors, including urothelial carcinoma in combination with PD-1 inhibition, have shown promising response rates and manageable toxicity, with peripheral neuropathy, hepatic enzyme elevations, cytopenias, and fatigue as common adverse events. Pembrolizumab is an anti–PD-1 antibody used widely in urothelial carcinoma to enhance antitumor immune responses. Control: Gemcitabine plus cisplatin or carboplatin, a standard first-line regimen in metastatic urothelial carcinoma depending on cisplatin eligibility.

Outcomes: Co-primary endpoints are progression-free survival by RECIST v1.1 per blinded independent central review and overall survival. Secondary endpoints include objective response rate and duration of response (BICR and investigator), disease control rate, investigator-assessed PFS, safety and tolerability (AEs, labs, ECGs, LVEF changes, discontinuations), and patient-reported outcomes including EORTC QLQ-C30 global health status/quality of life and time to deterioration, as well as time to pain progression.

Burden on patient: Moderate. Participation requires provision of archival tumor tissue or a new baseline biopsy if archival tissue is unavailable, which adds procedural burden if biopsy is needed. The experimental arm involves IV infusions every 2 weeks for disitamab vedotin with pembrolizumab every 6 weeks; the control arm involves gemcitabine on days 1 and 8 with cisplatin or carboplatin every 3 weeks, consistent with standard care visit frequency. Regular imaging for RECIST assessments, safety labs, ECGs, and LVEF monitoring are required and align with phase 3 oncology standards. No intensive pharmacokinetic sampling is specified. Travel and visit frequency are comparable to standard first-line therapy, with slightly increased monitoring due to the investigational ADC-immunotherapy combination and cardiac function assessments.

Eligibility

Show Criteria

Inclusion Criteria:

* Histopathological confirmation of locally advanced unresectable or metastatic urothelial carcinoma (LA/mUC), including UC originating from the renal pelvis, ureters, bladder, or urethra.

* Measurable disease by investigator assessment per RECIST v1.1.

* Participant must not have received prior systemic therapy for LA/mUC. Exception will be made for neoadjuvant or adjuvant therapy, if disease recurrence/progression occurred more than 12 months after the last dose of therapy.

* Eligible to receive cisplatin- or carboplatin-containing chemotherapy.

* Able to provide archived formalin-fixed paraffin-embedded tumor tissue blocks from a muscle-invasive or metastatic UC lesion or biopsy of metastatic UC prior to treatment initiation. If archival tissue is not available a newly obtained baseline biopsy of an accessible tumor lesion is required within 28 days of cycle 1 day 1.

* HER2 expression of 1+ or greater on immunohistochemistry (IHC).

* Eastern Cooperative Oncology Group (ECOG) performance score of 0, 1, or 2 within 7 days prior to randomization.

Exclusion Criteria:

* Known hypersensitivity to disitamab vedotin, cisplatin, carboplatin, gemcitabine, or pembrolizumab or any of their components.

* History of severe/life threatening immune-related adverse event (irAE) with PD-(L)1 inhibitors are excluded.

* Central nervous system (CNS) and/or leptomeningeal metastasis. Participants with treated CNS metastases are permitted if all of the following are met.

* CNS metastases have been clinically stable for at least 4 weeks and baseline scans show no evidence of new or worsening CNS metastasis.

* Participant is on a stable dose of ≤ 10 mg/day of prednisone or equivalent for at least 2 weeks.

* History of or active autoimmune disease that has required systemic treatment in the past 2 years.

* Prior treatment with an agent directed to another stimulatory or co-inhibitory T cell receptor (including but not limited to CD137 agonists, CAR-T cell therapy, CTLA-4 inhibitors, or OX-40 agonists).

* Prior solid organ or bone marrow transplantation.

* Pleural effusion or ascites with symptoms or requiring symptomatic treatment.

* Estimated life expectancy \<12 week

* Prior treatment with an MMAE agent or anti-HER2 therapy

Sites (329)

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Fundación Dr. Ruben Kowalyszyn

Viedma, Río Negro Province, 8500, Argentina

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Status: Recruiting

Comisión Provincial de Evaluación de Proyectos de Investigación en Salud Humana (CEEPISH)

Viedma, Río Negro Province, R8500ACE, Argentina

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Clinica Viedma

Viedma, Río Negro Province, 8500, Argentina

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Centro Medico Austral

Buenos Aire, C1019ABS, Argentina

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Centro Oncologico Korben

Buenos Aire, C1280AEB, Argentina

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Fundacion Cenit

CABA, 1125, Argentina

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Investigaciones Clinicas Moleculares (ICM)

CABA, 1425, Argentina

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CEMAIC - Centro Medico Privado

Córdoba, X5008HHW, Argentina

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Hospital Municipal de Morón. O. B. Lavignolle

Morón, 1708, Argentina

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Centro de Investigacion Pergamino SA

Pergamino, B2700CPM, Argentina

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Comité Provincial de Bioética-Rosario

Rosario, 2000, Argentina

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Sanatorio Parque

Rosario, 2000, Argentina

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Consultorio Dr. Miguel Angel Escudero

Salta, 4400, Argentina

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Centro para la Atencion Integral del paciente Oncologico

San Miguel de Tucumán, Argentina

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Oncologia Salta

Salta, 4400, Argentina

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Centro de Oncologia e Investigacion de Buenos Aires (COIBA)

Berazategui, B1884BBF, Argentina

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Instituto Médico Especializado Alexander Fleming

Buenos Aires, C1426ANZ, Argentina

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Prince of Wales Hospital

Randwick, New South Wales, 2031, Australia

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Concord Repatriation General Hospital

Concord, New South Wales, 2139, Australia

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Saint Vincents Hospital Sydney - Human Research Ethics Committee

Darlinghurst, New South Wales, 2010, Australia

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St Vincent's Clinic

Darlinghurst, New South Wales, 2010, Australia

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Macquarie University Hospital

Macquarie University, New South Wales, 2109, Australia

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Macquarie University

North Ryde, New South Wales, 2109, Australia

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North Shore Private Hospital

St Leonards, New South Wales, 2065, Australia

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Icon Cancer Centre Chermside

Herston, Queensland, 4029, Australia

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Mater Misericordiae - Mater Hospital Brisbane

Brisbane, Queensland, 4101, Australia

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Mater Research

South Bribane, Queensland, 4101, Australia

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Peninsula & South Eastern Hematology and Oncology Group (PASO)

Frankston, Victoria, 3199, Australia

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Status: Recruiting

Austin Health

Melbourne, Victoria, 3084, Australia

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Status: Not yet recruiting

Mater Cancer Care Centre

South Brisbane, 4101, Australia

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South Eastern Sydney Local Health District

Caringbah, 2229, Australia

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Lyell McEwin Hospital

Elizabeth Vale, 5112, Australia

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Peninsula And South East Oncology

Frankston, 3199, Australia

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Cabrini.

Malvern, 3144, Australia

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Mid North Coast Local Health District

NSW, NSW 2450, Australia

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Port Macquarie Base Hospital

Port Macquarie, 2444, Australia

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Royal North Shore Hospital

St Leonards, 2065, Australia

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GZA Hospital Sint-Augustinus

Wilrijk, 2610, Belgium

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CHU UCL Namur-Site de Saint Elisabeth

Namur, 5000, Belgium

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CHU de Liege Service Oncologie Medicale

Liège, 4000, Belgium

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University Hospital Ghent

Ghent, 9000, Belgium

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AZ St. Lucas

Ghent, 9000, Belgium

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Algemeen Ziekenhuis Maria Middelares

Ghent, 9000, Belgium

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Suporte Nutricional e Quimioterapia - PRONUTRIR

Fortaleza, Ceará, 60810-180, Brazil

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Centro de Oncologia da Bahia

Salvador, Estado de Bahia, 41820-021, Brazil

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Associacao Mario Penna - Hospital Luxemburgo - NEPI Nucleo de Ensino Pesquisa e Inovacao

Belo Horizonte, Minas Gerais, 30380472, Brazil

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Hospital Nossa Senhora da Conceicao / Grupo Hospitalar Conceicao

Porto Alegre, Rio Grande do Sul, 91350-200, Brazil

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Hospital Mae de Deus

Porto Alegre, Rio Grande do Sul, 90110-270, Brazil

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Hospital Sao Vicente de Paulo

Passo Fundo, Rio Grande do Sul, 99010-080, Brazil

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Pontificia Universidade Catolica do Rio Grande do Sul (PUCRS)

Porto Alegre, Rio Grande do Sul, 90610000, Brazil

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Fundacao Doutor Amaral Carvalho

Jaú, São Paulo, 17210080, Brazil

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Erasto Gaertner Hospital

CuriBba, 81520-060, Brazil

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Hospital de Cancer de Barretos - Fundacao Pio XII

Barretos, 14784-400, Brazil

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Hospital Alemao Oswaldo Cruz

São Paulo, 01327-001, Brazil

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Arthur J.E. Child Comprehensive Cancer Centre

Calgary, Alberta, T2N 5G2, Canada

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University of Alberta / Cross Cancer Institute

Edmonton, Alberta, T6G 1Z2, Canada

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Lakeridge Health - The R.S. McLaughlin Durham Regional Cancer Centre (MDRCC)

Oshawa, Ontario, L1G 2B9, Canada

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Princess Margaret Cancer Centre - University Health Network

Toronto, Ontario, M5G 2M9, Canada

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Centro de Estudios Clínicos SAGA

Santiago, 7500653, Chile

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Centro de Investigaciones Clinicas Vina del Mar

Viña del Mar, 2540402, Chile

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Fakultni nemocnice Hradec Kralove

Hradec Králové, Hradec Králové, 500 05, Czechia

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Fakultni Nemocnice Olomouc (Fnol) - Onkologicka Klinika

Olomouc, 779 00, Czechia

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Institut Gustave Roussy

Villejuif, 94805, France

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University Hospital of Besancon

Besançon, 25000, France

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Institut Bergonié Centre de Lutte Contre le Cancer (CLCC)

Bordeaux, 33076, France

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Centre de Lutte contre le Cancer - François Baclesse

Caen, 14076, France

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Institut Paoli Calmettes

Marseille, 13009, France

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Institut régional du Cancer de Montpellier - ICM Val d'Aurelle

Montpellier, 34298, France

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Pharmacy ICM Val d'Aurelle - Bat A - Rez-de-Jardin

Montpellier, 34298, France

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Centre de Lutte contre le Cancer (CLCC) - Centre Antoine Lacassagne

Nice, 06189, France

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Hopital Europeen Georges Pompidou

Paris, 75015, France

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Status: Not yet recruiting

Hospices Civils de Lyon

Pierre-Bénite, 69310, France

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Unite de Coordination de la Biologie des Essais Cliniques

Strasbourg, 67091, France

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Status: Recruiting

Institut de Cancerologie Strasbourg Europe

Strasbourg, 67200, France

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Status: Recruiting

Athens Medical Center

Marousi, Attikí, 151 25, Greece

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Status: Recruiting

Bioclinic Thessalonikis Private Clinic Single Member S.A.

Thessaloniki, Kentrikí Makedonía, 546 22, Greece

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Status: Recruiting

Metropolitan General Hospital

Cholargós, 15562, Greece

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Semmelweis Egyetem Urologiai Klinika

Budapest, 1082, Hungary

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Status: Not yet recruiting

Bacs-Kiskun Varmegyei Oktatokorhaz

Kecskemét, 6000, Hungary

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Status: Not yet recruiting

Nirmal Hospital Pvt Ltd

Surat, Gujarat, 395002, India

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Status: Not yet recruiting

Rajiv Gandhi Cancer Institute And Research Centre

New Delhi, National Capital Territory of Delhi, 110085, India

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Status: Not yet recruiting

Tallaght University Hospital

Tallaght, D24 NR0A, Ireland

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Status: Not yet recruiting

Cancer Trials Cork

Cork, T12 DC4A, Ireland

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Status: Not yet recruiting

Cork University Hospital

Wilton, T12 DC4A, Ireland

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Status: Not yet recruiting

Hadassah Medical Center

Jerusalem, Other, 91120, Israel

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Status: Recruiting

Shaare Zedek Medical Center

Jerusalem, Other, 9103102, Israel

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Status: Recruiting

Sheba Medical Center.

Ramat Gan, Other, 52621, Israel

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Status: Recruiting

Rambam Health Care Campus

Hafia, 3109601, Israel

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Status: Recruiting

Emek Medical Center

Afula, 1834111, Israel

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Status: Recruiting

Kaplan Medical Center

Rehovot, 7661041, Israel

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Status: Recruiting

Rabin Medical Center

Petah Tikva, 4941492, Israel

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Meir Medical Center

Kefar Sava, 4428164, Israel

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Tel Aviv Sourasky Medical Center

Tel Aviv, 6423906, Israel

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Status: Recruiting

Soroka Medical Center

Beersheba, 8410101, Israel

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Status: Recruiting

IRCCS Istituto Tumori Giovanni Paolo II

Bari, Apulia, 70124, Italy

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Status: Not yet recruiting

Azienda Ospedaliera Cardinale Giovanni Panico

Tricase, Apulia, 73039, Italy

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Status: Recruiting

Oncologia Medica, Ospedale Civile S. Maria delle Croci

Ravenna, Emilia-Romagna, 48121, Italy

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Status: Recruiting

Ospedale Policlinico San Martino

Genoa, Liguria, 16132, Italy

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Status: Recruiting

Ospedale San Raffaele

Milan, Lombardy, 20132, Italy

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Status: Recruiting

Istituto Clinico Humanitas-Humanitas Cancer Center

Rozzano (Milano), Lombardy, 20089, Italy

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Status: Recruiting

IRCCS - Ospedale San Raffaele

Milan, Milan, 20132, Italy

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Status: Recruiting

IRCCS Istituto Clinico Humanitas

Rozzano, Milano, 20089, Italy

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Status: Recruiting

Azienda Sanitaria Locale Napoli 2 Nord

Giugliano in Campania, Naples, 80014, Italy

No email / No phone

Status: Not yet recruiting

P.O. "S. Maria Delle Grazie" - Pozzuoli - ASL Napoli Nord 2

Pozzuoli (NA), Other, 80078, Italy

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Status: Not yet recruiting

Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari

Bari, Other, 70124, Italy

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Status: Not yet recruiting

ASL-AT, Ospedale Cardinal Massaia di Asti

Asti, Piedmont, 14100, Italy

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Status: Not yet recruiting

Centro di Riferimento Oncologico Di Aviano

Aviano, Pordenone, 33184, Italy

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Status: Recruiting

SOSD Farmacia Ospedaliera

Aviano, Pordenone, 33081, Italy

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Status: Recruiting

AUSL della Romagna - Ospedale degli infermi

Faenza, RA, 48018, Italy

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Status: Recruiting

AUSL Romagna - Presidio Ospedale "Umberto I" di Lugo

Lugo, Ravenna, 48022, Italy

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Status: Recruiting

Azienda Ospedaliero Universitaria Careggi

Florence, Tuscany, 50134, Italy

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Status: Recruiting

Azienda Ospedaliera S. Maria di Terni

Terni, Umbria, 05100, Italy

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Status: Recruiting

Azienda Ospedaliera Universitaria Integrata di Verona

Verona, 37136, Italy

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Status: Recruiting

ASL Asti - Ospedale Cardinal Massaia - S.C. Farmacia Ospedaliera

Asti, 14100, Italy

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Status: Not yet recruiting

ASST Cremona Farmacia Ospedaliera

Cremona, 26100, Italy

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Status: Recruiting

U.O. Farmacia Ospedaliera a Politiche del Farmaco Az. Osp. Universitaria Careggi

Florence, 50134, Italy

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Status: Recruiting

Ospedale Policlinico San Martino Farmacia

Genova, 16132, Italy

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Status: Recruiting

Istituto Nazionale Tumori IRCCS Fondazione G.Pascale Napoli Pascale

Napoli, 80131, Italy

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Status: Not yet recruiting

SC Farmacia Ospedaliera C/O Istituto Nazionale Tumori IRCCS Fondazione G.Pascale Napoli Pascale

Napoli, 80131, Italy

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Status: Not yet recruiting

Istituto Oncologico Veneto - IRCCS

Padua, 35128, Italy

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Status: Recruiting

Azienda Ospedaliera Universitaria Pisana Ospedale Santa Chiara

Pisa, 56126, Italy

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Status: Recruiting

Azienda Ospedaliera Universitaria Pisana, U.O. Farmacia Ospedaliera

Pisa, 56126, Italy

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Status: Recruiting

Policlinico Universitario Agostino Gemelli

Roma, 00168, Italy

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Status: Recruiting

Centro Ricerche Cliniche Di Verona Srl

Verona, 37134, Italy

No email / No phone

Status: Recruiting

Hirosaki University Hospital

Hirosaki, Aomori, 036-8563, Japan

No email / No phone

Status: Not yet recruiting

Ehime University Hospital

Tōon, Ehime, 791 -0295, Japan

No email / No phone

Status: Not yet recruiting

National Hospital Organization Kyushu Cancer Center

Fukuoka, Fukuoka, 811-1395, Japan

No email / No phone

Status: Not yet recruiting

Gunma Prefectural Cancer Center

Ota-Shi, Gunma, 373-8550, Japan

No email / No phone

Status: Not yet recruiting

Kobe University Hospital

Kobe, Hyōgo, 650-0017, Japan

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Status: Not yet recruiting

University of Tsukuba Hospital

Tsukuba, Ibaraki, 305-8576, Japan

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Status: Not yet recruiting

Kagawa University Hospital

Kita-gun, Kagawa-ken, 761-0793, Japan

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Status: Recruiting

Yokohama City University Medical Center

Yokohama, Kanagawa, 232-0024, Japan

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Status: Recruiting

Kanagawa Cancer Center

Yokohama, Kanagawa, 241-8515, Japan

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Status: Not yet recruiting

University of Miyazaki Hospital

Miyazaki, Miyazaki, 889-1692, Japan

No email / No phone

Status: Not yet recruiting

Nara Medical University Hospital

Kashihara, Nara, 634-8522, Japan

No email / No phone

Status: Not yet recruiting

Kindai University Hospital

Osakasayama-Shi, Osaka, 589-8511, Japan

No email / No phone

Status: Not yet recruiting

Osaka University Hopsital

Suita, Osaka, 565-0871, Japan

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Status: Not yet recruiting

Tokushima University Hospital

Tokushima, Tokushima, 770-8503, Japan

No email / No phone

Status: Recruiting

Keio University Hospital

Shinjuku-ku, Tokyo, 160-8582, Japan

No email / No phone

Status: Not yet recruiting

Wakayama Medical University Hospital

Wakayama, Wakayama, 641-8510, Japan

No email / No phone

Status: Not yet recruiting

Yamaguchi University Hospital

Ube, Yamaguchi, 755-8505, Japan

No email / No phone

Status: Not yet recruiting

National Hospital Organization Kumamoto Medical Center

Kumamoto, 860-0008, Japan

No email / No phone

Status: Recruiting

Chiba Cancer Center

Chiba, 260-8717, Japan

No email / No phone

Status: Not yet recruiting

Osaka Prefectural Hospital Organization - Osaka International Cancer Institute

Osaka, 541-8567, Japan

No email / No phone

Status: Not yet recruiting

Yamagata University Hospital

Yamagata, 990-9585, Japan

No email / No phone

Status: Not yet recruiting

Amphia Ziekenhuis

Breda, North Brabant, 4818 CK, Netherlands

No email / No phone

Status: Not yet recruiting

Haga Ziekenhuis

The Hague, South Holland, 2545 AA, Netherlands

No email / No phone

Status: Recruiting

Antoni van Leeuwenhoek Apotheek,I-2

Amsterdam, 1066 CX, Netherlands

No email / No phone

Status: Not yet recruiting

Netherlands Cancer Institute/Antoni van Leeuwenhoek

Amsterdam, 1066 CX, Netherlands

No email / No phone

Status: Not yet recruiting

Rijnstate Hospital

Arnhem, 6815 AD, Netherlands

No email / No phone

Status: Recruiting

Maastricht Universitair Medisch Centrum+

Maastricht, 6229 HX, Netherlands

No email / No phone

Status: Not yet recruiting

Radboud University Medical Center

Nijmegen, 6525 GA, Netherlands

No email / No phone

Status: Recruiting

Akershus universitetssykehus HF

Lørenskog, Akershus, N-1478, Norway

No email / No phone

Status: Not yet recruiting

Avdeling for blod og kreft sykdommer. Stavanger universitetssykehus

Stavanger, 4011, Norway

No email / No phone

Status: Not yet recruiting

Hospital Militar Central Coronel Luis Arias Schreiber

Lima, 15076, Peru

No email / No phone

Status: Not yet recruiting

Hospital Maria Auxiliadora

Lima, 15081, Peru

No email / No phone

Status: Recruiting

Hospital de Braga

Sao Victor, Braga District, 4710-243, Portugal

No email / No phone

Status: Recruiting

Hospital de Braga

Braga, 4710-243, Portugal

No email / No phone

Status: Recruiting

Centro Clinico Champalimaud

Lisbon, 1400, 038, Portugal

No email / No phone

Status: Recruiting

Champalimaud Clinical Center

Lisbon, 1400-038, Portugal

No email / No phone

Status: Recruiting

Hospital de Santa Maria - Centro Hospitalar Universitario Lisboa Norte

Lisbon, 1649-028, Portugal

No email / No phone

Status: Recruiting

Centro Hospitalar Universitário de São João

Porto, 4200-319, Portugal

No email / No phone

Status: Not yet recruiting

National University Hospital

Singapore, 119074, Singapore

No email / No phone

Status: Active, not recruiting

National University Cancer Institute

Singapore, 119228, Singapore

No email / No phone

Status: Active, not recruiting

National Cancer Centre Singapore

Singapore, 168583, Singapore

No email / No phone

Status: Recruiting

Raffles Hospital

Singapore, 188770, Singapore

No email / No phone

Status: Recruiting

National Cancer Center

Goyang-si, Gyeonggi-do, 10408, South Korea

No email / No phone

Status: Recruiting

CHA Bundang Medical Center, CHA University

Seongnam-si, Gyeonggi-do, 13496, South Korea

No email / No phone

Status: Recruiting

The Catholic University of Korea, St. Vincent's Hospital

Suwon, Gyeonggi-do, 16247, South Korea

No email / No phone

Status: Recruiting

Jeonbuk National University Hospital

Jeonju, Jeollabuk-do, 54907, South Korea

No email / No phone

Status: Recruiting

Chonnam National University Hwasun Hospital

Hwasun-gun, Jeollanam-do, 58128, South Korea

No email / No phone

Status: Recruiting

Wonkwang University Hospital

Iksan-si, Jeonlabuk-do, 54538, South Korea

No email / No phone

Status: Recruiting

Inje University Haeundae Paik Hospital

Busan, 48108, South Korea

No email / No phone

Status: Recruiting

Kosin University Gospel Hospital

Busan, 49267, South Korea

No email / No phone

Status: Not yet recruiting

Gachon University Gil Medical Center

Incheon, 21565, South Korea

No email / No phone

Status: Recruiting

Seoul National University Bundang Hospital

Seongnam-si, 463-707, South Korea

No email / No phone

Status: Recruiting

Korea University Anam Hospital

Seoul, 02841, South Korea

No email / No phone

Status: Recruiting

Kangbuk Samsung Hospital

Seoul, 03181, South Korea

No email / No phone

Status: Recruiting

Severance Hospital Yonsei University Health System

Seoul, 03722, South Korea

No email / No phone

Status: Recruiting

Asan Medical Center - Oncology

Seoul, 05505, South Korea

No email / No phone

Status: Recruiting

Complejo Hospitalario Universitario de Santiago

Santiago de Compostela, A Coruna, 15706, Spain

No email / No phone

Status: Not yet recruiting

Farmacia Oncologica - Unidad de Ensayos Clinicos

Santiago de Compostela, A Coruna, Spain, Spain

No email / No phone

Status: Not yet recruiting

Hospital Universitario Badajoz

Badajoz, A Coruña [LA Coruña], 06080, Spain

No email / No phone

Status: Not yet recruiting

Institut Catala d' Oncologia de Badalona - Hospital Universitari Germans Trias i Pujos

Badalona, Barcelona, 08916, Spain

No email / No phone

Status: Recruiting

Institut Catala d'Oncologia Badalona (ICO Badalona) - Hospital Universitari Germans Trias i Pujol

Badalona, Barcelona, 08916, Spain

No email / No phone

Status: Recruiting

Institut Catala d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet)

L'Hospitalet de Llobregat, Barcelona, 08908, Spain

No email / No phone

Status: Recruiting

Hospital de Cruzes

Barakaldo, Bizkaia, 48903, Spain

No email / No phone

Status: Not yet recruiting

Hospital Universitario Marques de Valdecilla

Santander, Cantabria, 39008, Spain

No email / No phone

Status: Recruiting

Hospital Universitario Puerta de Hierro - Majadahonda

Majadahonda, Madrid, 28222, Spain

No email / No phone

Status: Recruiting

Hospital Universitario La Paz

Madrid, 28046, Spain

No email / No phone

Status: Recruiting

Consorcio Hospital General Universitario de Valencia (CHGUV)

Valencia, 46014, Spain

No email / No phone

Status: Not yet recruiting

Hospital Universitario Virgen Del Rocio

Seville, 41013, Spain

No email / No phone

Status: Recruiting

Complejo Hospitalario Universitario de Ourense (CHOU)

Ourense, 32005, Spain

No email / No phone

Status: Recruiting

Hospital Universitario HM Sanchinarro

Madrid, 28050, Spain

No email / No phone

Status: Recruiting

HM Centro Integral Oncologico Clara Campal

Madrid, 28050, Spain

No email / No phone

Status: Recruiting

Hospital Universitario La Paz: Servicio de Farmacia

Madrid, 28046, Spain

No email / No phone

Status: Recruiting

Hospital Universitario 12 de Octubre

Madrid, 28041, Spain

No email / No phone

Status: Recruiting

Hospital Universitario Ramon y Cajal

Madrid, 28034, Spain

No email / No phone

Status: Recruiting

MD Anderson Cancer Center Madrid

Madrid, 28033, Spain

No email / No phone

Status: Recruiting

Hospital General Universitario Gregorio Maranon

Madrid, 28009, Spain

No email / No phone

Status: Recruiting

Hospital General Universitario Gregorio Maranon

Madrid, 28007, Spain

No email / No phone

Status: Recruiting

Complejo Hospitalario Universitario Insular Materno-Infantil

Las Palmas de Gran Canaria, 35016, Spain

No email / No phone

Status: Recruiting

Unitat d'Assajos Clinics Servei de Farmacia

L'Hospitaler de Llobregat, 08908, Spain

No email / No phone

Status: Recruiting

Hospital de La Santa Creu i Sant Pau

Barcelona, 08041, Spain

No email / No phone

Status: Recruiting

Hospital de la Santa Creu i Sant Pau- Pharmacy

Barcelona, 08041, Spain

No email / No phone

Status: Recruiting

Hospital Clinic de Barcelona

Barcelona, 08036, Spain

No email / No phone

Status: Recruiting

Hospital Universitari Vall d'Hebron

Barcelona, 08035, Spain

No email / No phone

Status: Recruiting

Hospital Universitari Vall D Hebron

Barcelona, 08035, Spain

No email / No phone

Status: Recruiting

Hospital Del Mar

Barcelona, 08003, Spain

No email / No phone

Status: Recruiting

Infanta Cristina Hospital

Badajoz, 06080, Spain

No email / No phone

Status: Not yet recruiting

Hospital Universitario Miguel Servet

Zaragoza, 50009, Spain

No email / No phone

Status: Recruiting

Consorcio Hospital General Universitario de Valencia

Valencia, 46014, Spain

No email / No phone

Status: Not yet recruiting

Ryhov Hospital

Jönköping, 551 85, Sweden

No email / No phone

Status: Active, not recruiting

Karolinska University Hospital

Stockholm, 171 76, Sweden

No email / No phone

Status: Recruiting

Chang Gung Memorial Hospital Kaohsiung Branch

Kaohsiung City, 833, Taiwan

No email / No phone

Status: Not yet recruiting

Kaohsiung Chang Gung Memorial Hospital

Kaohsiung City, 833401, Taiwan

No email / No phone

Status: Not yet recruiting

China Medical University Hospital

Taichung, 404, Taiwan

No email / No phone

Status: Recruiting

China Medical University Hospital - Pharmacy

Taichung, 40447, Taiwan

No email / No phone

Status: Recruiting

National Taiwan University Hospital, Investigational Drug Service

Taipei, 100, Taiwan

No email / No phone

Status: Recruiting

Chi Mei Hospital liouying

Tainan City, 73657, Taiwan

No email / No phone

Status: Recruiting

National Cheng-Kung University Hospital

Tainan City, 70403, Taiwan

No email / No phone

Status: Recruiting

Clinical Trial Pharmacy, Department of Pharmacy, National Cheng Kung University Hospital

Tainan City, 704017, Taiwan

No email / No phone

Status: Recruiting

Taichung Veterans General Hospital

Taichung, 40705, Taiwan

No email / No phone

Status: Recruiting

Taichung Veterans General Hospital Clinical Trials Pharmacy

Taichung, 40705, Taiwan

No email / No phone

Status: Recruiting

Kaohsiung Medical University Hospital

Kaohsiung City, 807, Taiwan

No email / No phone

Status: Recruiting

National Taiwan University Hospital

Taipei, 100, Taiwan

No email / No phone

Status: Recruiting

NHS Greater Glasgow and Clyde (NHSGGC) - The Beatson West of Scotland Cancer Centre

Glasgow, Other, G12 0YN, United Kingdom

No email / No phone

Status: Not yet recruiting

Guy's and St Thomas' NHS Foundation

London, SE1 9RT, United Kingdom

No email / No phone

Status: Not yet recruiting

Guy's and St Thomas' NHS Foundation Trust

London, SE1 7EH, United Kingdom

No email / No phone

Status: Not yet recruiting

Barts Health NHS Trust Saint Bartholomews Hospital

London, EC1A 7BE, United Kingdom

No email / No phone

Status: Recruiting

Banner MD Anderson Cancer Center

Gilbert, Arizona, 85234, United States

No email / No phone

Status: Active, not recruiting

Banner Gateway Medical Center

Gilbert, Arizona, 85234, United States

No email / No phone

Status: Active, not recruiting

Administrative Address: UCLA Hematology/Oncology

Los Angeles, California, 90095, United States

No email / No phone

Status: Recruiting

UCLA Downtown Los Angeles Primary & Specialty Care

Los Angeles, California, 90017, United States

No email / No phone

Status: Recruiting

Helios Clinical Research

Long Beach, California, 90805, United States

No email / No phone

Status: Recruiting

Foothill Cardiology Glendora

Glendora, California, 91741, United States

No email / No phone

Status: Recruiting

UCLA Hematology/Oncology - Encino

Encino, California, 91436, United States

No email / No phone

Status: Recruiting

UCLA Encino Specialty Care (Radiology)

Encino, California, 91436, United States

No email / No phone

Status: Recruiting

UCLA Calabasas Specialty Care

Calabasas, California, 91302, United States

No email / No phone

Status: Recruiting

UCLA Hematology/Oncology - Burbank

Burbank, California, 91505, United States

No email / No phone

Status: Recruiting

UCLA Burbank Cardiology

Burbank, California, 91505, United States

No email / No phone

Status: Recruiting

Providence Saint Joseph Medical Center

Burbank, California, 91505, United States

No email / No phone

Status: Recruiting

Beverly Hills Multi-Specialties Practice

Beverly Hills, California, 90211, United States

No email / No phone

Status: Recruiting

Foothill Cardioology

Arcadia, California, 91007, United States

No email / No phone

Status: Recruiting

UCLA Hematology/Oncology - Alhambra

Alhambra, California, 91801, United States

No email / No phone

Status: Recruiting

Helios Clinical Research

Glendale, California, 91204, United States

No email / No phone

Status: Recruiting

Helios Clinical Research

Whittier, California, 90602, United States

No email / No phone

Status: Recruiting

UCLA Hematology/Oncology - Westlake

Westlake Village, California, 91361, United States

No email / No phone

Status: Recruiting

UCLA Ventura Cardiology

Ventura, California, 93003, United States

No email / No phone

Status: Recruiting

UCLA Santa Clarita Primary & Specialty Care

Valencia, California, 91355, United States

No email / No phone

Status: Recruiting

UCLA Torrance Lomita Specialty Care

Torrance, California, 90505, United States

No email / No phone

Status: Recruiting

UCLA Hematology/Oncology - Torrance

Torrance, California, 90505, United States

No email / No phone

Status: Recruiting

UCLA Thousand Oaks Primary & Specialty Care

Thousand Oaks, California, 91360, United States

No email / No phone

Status: Recruiting

Twin Cities Community Hospital

Templeton, California, 93455, United States

No email / No phone

Status: Recruiting

UCLA Simi Valley Alamo Specialty Care

Simi Valley, California, 93065, United States

No email / No phone

Status: Recruiting

UCLA Hematology/Oncology - Santa Monica

Santa Monica, California, 90404, United States

No email / No phone

Status: Recruiting

UCLA Hematology/Oncology - Santa Barbara

Santa Barbara, California, 93105, United States

No email / No phone

Status: Recruiting

Helios Clinical Research

Santa Ana, California, 92705, United States

No email / No phone

Status: Recruiting

Sierra Vista Regional Medical Center

San Luis Obispo, California, 93405, United States

No email / No phone

Status: Recruiting

UCLA Hematology/Oncology - San Luis Obispo

San Luis Obispo, California, 93401, United States

No email / No phone

Status: Recruiting

Southern California Heart Centers

San Gabriel, California, 91776, United States

No email / No phone

Status: Recruiting

Diagnostic Medical Group of Southern California, , San Gabriel, CA

San Gabriel, California, 91776, United States

No email / No phone

Status: Recruiting