Eligibility Criteria
Show Criteria
Inclusion Criteria:
1. Aged at least 18 years old (or per local regulatory/IRB requirement).
2. Histologically or cytologically confirmed diagnosis of non-squamous NSCLC, locally advanced (Stage IIIB and IIIC according to the 8th edition of the AJCC TNM staging criteria) or metastatic (Stage IV), not suitable for curative therapy.
3. Adequate tumor tissue available, for central laboratory confirmation of EGFR exon 20 insertion mutation
4. At least 1 measurable lesion per RECIST Version 1.1
5. Life expectancy ≥ 12 weeks
6. Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 1
7. Adequate organ and hematologic function
Exclusion Criteria:
1. Prior treatment with any systemic anti-cancer therapy for locally advanced or metastatic NSCLC.
2. Spinal cord compression or leptomeningeal metastasis.
3. Concurrent EGFR mutations: exon 19 deletion, L858R, T790M, G719X, S768I, or L861Q.
4. History of stroke or intracranial hemorrhage within 6 months before randomization.
5. As judged by the investigator, any evidence of severe or uncontrolled systemic diseases, including uncontrolled hypertension and active bleeding diatheses (i.e., hemophilia and Von Willebrand disease).
Sites (160)
Sort by distance to:
Centro Diabaid
Buenos Aires, Argentina
No email / No phone
Status: Not yet recruiting
Instituto Alexander Fleming
Buenos Aires, Argentina
No email / No phone
Status: Not yet recruiting
Hospital Italiano de Buenos Aires (HIBA)
Buenos Aires, Argentina
No email / No phone
Status: Not yet recruiting
Fundacion Cenit Para El Estudio De Neurociencias
Buenos Aires, Argentina
No email / No phone
Status: Completed
Consultorios Medicos Dr. Doreski - Fundacion Respirar
Buenos Aires, Argentina
No email / No phone
Status: Completed
Centro de Educación Médica e Investigaciones Clínicas, CEMIC
Buenos Aires, Argentina
No email / No phone
Status: Not yet recruiting
Centro Medico Austral
Buenos Aires, Argentina
No email / No phone
Status: Completed
Centro de Investigación Clínicas. Clinica Viedma S.A
Viedma, Argentina
No email / No phone
Status: Not yet recruiting
Fundación Ars Médica
San Salvador, Argentina
No email / No phone
Status: Completed
Fundación Estudios Clínicos
Rosario, Argentina
No email / No phone
Status: Completed
Instituto Argentino de Diagnositco y Tratamiento S.A
Buenos Aires, Argentina
No email / No phone
Status: Completed
Prince of Wales Hospital
Randwick, Australia
No email / No phone
Status: Recruiting
Sir Charles Gairdner Hospital, Heart Research Insititute
Nedlands, Australia
No email / No phone
Status: Recruiting
Peter MacCallum Cancer Centre
Melbourne, Australia
No email / No phone
Status: Recruiting
Concord Cancer Centre Medical Oncology Clinical Trials Unit Concord Repatriation General Hospital
Concord, Australia
No email / No phone
Status: Recruiting
Uniklinikum Salzburg
Salzburg, Austria
No email / No phone
Status: Recruiting
Ordensklinikum Linz GmbH Elisabethinen
Linz, Austria
No email / No phone
Status: Recruiting
Antwerpen University Hospital (UZA)
Edegem, Antwerp, Belgium
No email / No phone
Status: Recruiting
University Hospital Gent- Drug Research Unit Ghent (D.R.U.G.)
Ghent, Flanders, Belgium
No email / No phone
Status: Recruiting
Grand Hopital de Charleroi (GHdC) - Hopital Notre Dame
Charleroi, Hainaut, Belgium
No email / No phone
Status: Recruiting
Fundacao PIO XII - Hospital do Cancer de Barretos
Barretos, Brazil
No email / No phone
Status: Recruiting
Liga Norte Riograndense Contra o Câncer
Natal, Brazil
No email / No phone
Status: Recruiting
Hospital São Lucas da PUCRS
Porto Alegre, Brazil
No email / No phone
Status: Recruiting
Santa Casa de Misericordia- Porto Alegre - Hospital Santa Rita
Porto Alegre, Brazil
No email / No phone
Status: Recruiting
Instituto D'Or de Pesquisa e Ensino - Recife
Recife, Brazil
No email / No phone
Status: Recruiting
Instituto America(COI)
Rio De Janeiro, Brazil
No email / No phone
Status: Recruiting
Instituto D'Or de Pesquisa e Ensino
Rio De Janeiro, Brazil
No email / No phone
Status: Recruiting
Instituto Nacional de Cancer Jose Alencar Gomes da Silva
Rio De Janeiro, Brazil
No email / No phone
Status: Recruiting
Instituto do Cancer do Estado de Sao Paulo - ICES
São Paulo, Brazil
No email / No phone
Status: Recruiting
Centro de Pesquisas Clinicas em
Cachoeiro De Itapemirim, Brazil
No email / No phone
Status: Recruiting
The Ottawa Hospital Cancer Center
Ottawa, Canada
No email / No phone
Status: Recruiting
Princess Margaret Cancer Center
Toronto, Canada
No email / No phone
Status: Recruiting
Regional Cancer Program London Health Sciences Centre
London, Canada
No email / No phone
Status: Recruiting
The First Affiliated Hospital of Sun Yat-sen University
Guangzhou, China
No email / No phone
Status: Recruiting
Beijing Cancer Hospital
Beijing, China
No email / No phone
Status: Recruiting
Beijing Chest Hospital, Capital Medical University
Beijing, China
No email / No phone
Status: Recruiting
Cancer Hospital of the Chinese Academy of Medical Sciences
Beijing, China
No email / No phone
Status: Recruiting
Peking Union Medical College Hospital
Beijing, China
No email / No phone
Status: Recruiting
Peking University Third Hospital
Beijing, China
No email / No phone
Status: Completed
Hunan Cancer Hospital
Changsha, China
No email / No phone
Status: Recruiting
West China Hospital of Sichuan University
Chengdu, China
No email / No phone
Status: Recruiting
Army Medical Center of PLA
Chongqing, China
No email / No phone
Status: Not yet recruiting
Chongqing Cancer Hospital
Chongqing, China
No email / No phone
Status: Recruiting
Fujian Cancer Hospital
Fuzhou, China
No email / No phone
Status: Recruiting
Fujian Medical University Union Hospital
Fuzhou, China
No email / No phone
Status: Recruiting
The First Affiliated Hospital of Guangzhou Medical University
Guangzhou, China
No email / No phone
Status: Recruiting
The First Affiliated Hospital Zhejiang University School of Medicine
Hangzhou, China
No email / No phone
Status: Recruiting
Zhejiang Cancer Hospital
Hangzhou, China
No email / No phone
Status: Recruiting
Harbin Medical University Cancer Hospital
Harbin, China
No email / No phone
Status: Recruiting
Anhui Provincial Hospital
Hefei, China
No email / No phone
Status: Recruiting
The First Affiliated Hospital of Anhui Medical University
Hefei, China
No email / No phone
Status: Recruiting
The Affiliated Hospital of Inner Mongolia Medical University
Hohhot, China
No email / No phone
Status: Completed
Jilin Cancer Hospital
Jilin, China
No email / No phone
Status: Recruiting
Central Hospital Affiliated to Shandong First Medical University
Jinan, China
No email / No phone
Status: Recruiting
Shandong Cancer Hospital & Institution
Jinan, China
No email / No phone
Status: Recruiting
Yunnan Cancer Hospital
Kunming, China
No email / No phone
Status: Recruiting
The Second Affiliated Hospital of Nanchang University
Nanchang, China
No email / No phone
Status: Recruiting
Jiangsu Cancer Hospital
Nanjing, China
No email / No phone
Status: Recruiting
Jiangsu Provincial Hospital
Nanjing, China
No email / No phone
Status: Recruiting
Guangxi Medical University Cancer Hospital
Nanning, China
No email / No phone
Status: Recruiting
Shanghai Chest Hospital
Shanghai, China
No email / No phone
Status: Recruiting
Shanghai Pulmonary Hospital
Shanghai, China
No email / No phone
Status: Recruiting
ZhongShan Hospital Fudan University
Shanghai, China
No email / No phone
Status: Recruiting
The First Hospital of China Medical University
Shenyang, China
No email / No phone
Status: Recruiting
Cancer Hospital Chinese Academy of Medical Sciences, ShenZhen center
Shenzhen, China
No email / No phone
Status: Completed
The Fourth Hospital of Hebei Medical University
Shijiazhuang, China
No email / No phone
Status: Recruiting
Shanxi Provincial Cancer Hospital
Taiyuan, China
No email / No phone
Status: Recruiting
Taizhou Hospital of Zhejiang Province
Taizhou, China
No email / No phone
Status: Recruiting
Tianjin Medical University Cancer Institute & Hospital
Tianjin, China
No email / No phone
Status: Recruiting
Tongji Hospital affiliated to Tongji Medical College of Huazhong University of Science & Technology
Wuhan, China
No email / No phone
Status: Recruiting
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, China
No email / No phone
Status: Recruiting
The First Affiliated Hospital of Xi 'an Jiaotong University
Xi'an, China
No email / No phone
Status: Recruiting
Yantai Yuhuangding Hospital
Yantai, China
No email / No phone
Status: Recruiting
Henan Cancer Hospital
Zhengzhou, China
No email / No phone
Status: Recruiting
The First Affiliated Hospital of Zhengzhou University
Zhengzhou, China
No email / No phone
Status: Recruiting
Vitkovicka Nemocnice a.s. - Plicni oddeleni
Ostrava, Czechia
No email / No phone
Status: Recruiting
Fakultni Nemocnice Olomouc (FNOL) - Onkologicka Klinika
Olomouc, Czechia
No email / No phone
Status: Recruiting
Hopital d'Instruction Des Armees Begin
Saint-Mande, France
No email / No phone
Status: Recruiting
Institut de Cancerologie de L'Ouest
Saint Herblain, France
No email / No phone
Status: Recruiting
Centre Hospitalier Universitaire de Nantes (CHU de Nantes)
Saint Herblain, France
No email / No phone
Status: Recruiting
CHU Poitiers
Poitiers, France
No email / No phone
Status: Recruiting
Hôpital Bichat - Claude Bernard
Paris, France
No email / No phone
Status: Recruiting
Hopital Saint Joseph
Paris, France
No email / No phone
Status: Not yet recruiting
Cochin Hospital
Paris, France
No email / No phone
Status: Recruiting
APHP Hôpital Tenon
Paris, France
No email / No phone
Status: Recruiting
Centre de Cancérologie Montpellier
Montpellier, France
No email / No phone
Status: Recruiting
APHM-Hôpital NORD
Marseille, France
No email / No phone
Status: Recruiting
Centre Hospitalier Universitaire Grenoble Alpes (CHU Grenoble Alpes) - Hopital Albert Michallon
La Tronche, France
No email / No phone
Status: Recruiting
Centre Hospitalier Universitaire de Lille (CHU Lille) - Hopital Albert Calmette - Clinique des Maladies Respiratoires
Hellemmes-Lille, France
No email / No phone
Status: Recruiting
Centre Hospitalier Intercommunal de Creteil (CHIC)
Créteil, France
No email / No phone
Status: Recruiting
Hôpital Louis Pradel
Bron, France
No email / No phone
Status: Recruiting
Centre Hospitalier Universitaire d'Angers
Angers, France
No email / No phone
Status: Recruiting
Hopital Foch
Suresnes, France
No email / No phone
Status: Recruiting
Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz - III. Medizinische Klinik und Poliklinik
Mainz, Germany
No email / No phone
Status: Recruiting
Evangelische Lungenklinik Berlin - Klinik fuer Pneumologie
Berlin, Germany
No email / No phone
Status: Recruiting
Asklepios Klinik Gauting GmbH - Klinik fuer Thorakale Onkologie
Gauting, Germany
No email / No phone
Status: Recruiting
Niels-Stensen-Kliniken - Franziskus-Hospital Harderberg
Georgsmarienhütte, Germany
No email / No phone
Status: Recruiting
Universitaetsklinikum Heidelberg (UKHD) - Thoraxklinik-Heidelberg gGmbH
Heidelberg, Germany
No email / No phone
Status: Recruiting
Pius-Hospital Oldenburg - Klinik fuer Haematologie und Onkologie
Oldenburg, Germany
No email / No phone
Status: Recruiting
Azienda Ospedaliera di Reggio Emilia - Arcispedale S. Maria Nuova (ASMN)
Reggio Emilia, Italy
No email / No phone
Status: Recruiting
Azienda Ospedaliera Universitaria Senese - Istituto Toscano Tumori (ITT) - Center for Immuno-Oncology (CIO)
Siena, Italy
No email / No phone
Status: Recruiting
IRCCS Istituti Fisioterapici Ospitalieri- Istituto Nazionale tumori Regina Elena
Roma, Italy
No email / No phone
Status: Recruiting
Servizio Sanitario Regionale Emilia-Romagna - Istituto Scientifico Romagnolo per lo Studio e La Cura dei Tumori Srl (IRST)
Meldola, Italy
No email / No phone
Status: Recruiting
Azienda Ospedaliero-Universitaria di Modena (AOU Modena) - Policlinico di Modena
Modena, Italy
No email / No phone
Status: Recruiting
Azienda Ospedaliera San Gerardo - Monza
Monza, Italy
No email / No phone
Status: Recruiting
La Maddalena Casa di Cura di Alta Specialita - Palermo
Palermo, Italy
No email / No phone
Status: Recruiting
Azienda Ospedaliero-Universitaria di Parma
Parma, Italy
No email / No phone
Status: Recruiting
Azienda Unità Sanitaria Locale Romagna
Ravenna, Italy
No email / No phone
Status: Recruiting
Università degli Studi di Firenze - Azienda Ospedaliero-Universitaria Careggi (AOUC) - SC di Oncologia MedicaI
Florence, Italy
No email / No phone
Status: Recruiting
Centro di Riferimento Oncologico (CRO Aviano)
Aviano, Italy
No email / No phone
Status: Recruiting
Azienda Ospedaliero Universitaria di Bologna - Policlinico S. Orsola-Malpighi
Bologna, Italy
No email / No phone
Status: Recruiting
Azienda Ospedaliero - Universitaria "Policlinico-Vittorio Emanuele" Catania
Catania, Italy
No email / No phone
Status: Recruiting
Azienda USL Toscana Sud Est -Ospedale Misericordia - Grosseto
Grosseto, Italy
No email / No phone
Status: Recruiting
Universiteit Maastricht (UM) - Maastricht University Medical Centre (Maastricht UMC+)
Maastricht, Netherlands
No email / No phone
Status: Not yet recruiting
Uniwersyteckie Centrum Kliniczne, Klinika Onkologii i Radioterapii
Gdańsk, Poland
No email / No phone
Status: Recruiting
Wojewódzki Szpital im. św. Ojca Pio
Przemyśl, Poland
No email / No phone
Status: Recruiting
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie Panstwowy
Warsaw, Poland
No email / No phone
Status: Recruiting
MED-POLONIA Sp. z o.o.
Poznań, Poland
No email / No phone
Status: Recruiting
Hospital Universitario Fundación Jiménez Diaz
Madrid, Spain
No email / No phone
Status: Recruiting
Hospital Regional Universitario de Málaga
Málaga, Spain
No email / No phone
Status: Recruiting
Hospital Universitario Virgen de Valme
Sevilla, Spain
No email / No phone
Status: Recruiting
Hospital Universitario Virgen del Rocio
Sevilla, Spain
No email / No phone
Status: Recruiting
Hospital Universitario Virgen Macarena
Sevilla, Spain
No email / No phone
Status: Recruiting
Hospital Clinico Universitario de Valencia
Valencia, Spain
No email / No phone
Status: Recruiting
Hospital Universitari i Politècnic La Fe
Valencia, Spain
No email / No phone
Status: Recruiting
Complejo Hospitalario Universitario A Coruña
A Coruña, Spain
No email / No phone
Status: Recruiting
Hospital de la Santa Creu i Sant Pau
Barcelona, Spain
No email / No phone
Status: Recruiting
Hospital Universitari Vall d'Hebron
Barcelona, Spain
No email / No phone
Status: Recruiting
Institut Catala d'Oncologia Badalona (ICO Badalona) - Hospital Germans Trias i Pujol
Barcelona, Spain
No email / No phone
Status: Recruiting
Instituto Oncológico Dr Rosell Hospital Quiron Dexeus
Barcelona, Spain
No email / No phone
Status: Recruiting
UOMI Cancer Center - Clinica Tres Torres
Barcelona, Spain
No email / No phone
Status: Recruiting
Institut Catala d'Oncologia de Girona -Hospital Universitari Dr Josep Trueta
Girona, Spain
No email / No phone
Status: Recruiting
Hospital Universitario de Jerez
Jerez De La Frontera, Spain
No email / No phone
Status: Recruiting
Clínica Universidad de Navarra - Madrid
Madrid, Spain
No email / No phone
Status: Recruiting
Hospital HM Sanchinarro
Madrid, Spain
No email / No phone
Status: Recruiting
Hospital Universitario 12 de Octubre
Madrid, Spain
No email / No phone
Status: Recruiting
Hospital Universitario La Paz
Madrid, Spain
No email / No phone
Status: Recruiting
Ankara Bilkent City Hospital Universiteler Mahallesi
Ankara, Turkey
No email / No phone
Status: Recruiting
Dr. Abdurrahman Yurtaslan Ankara Oncology Training
Ankara, Turkey
No email / No phone
Status: Recruiting
Necmettin Erbakan University
Konya, Turkey
No email / No phone
Status: Recruiting
Prof. Dr. Süleyman Yalçın Şehir Hastanesi - Tibbi Onkoloji Klinigi
Kadıköy, Turkey
No email / No phone
Status: Recruiting
Bezmialem University Hospital
Istanbul, Turkey
No email / No phone
Status: Recruiting
Trakya Universitesi Saglik Arastirma ve Uygulama Merkezi Hastane
Edirne, Turkey
No email / No phone
Status: Recruiting
Liv Hospital Ankara - Medical Oncology Clinic
Ankara, Turkey
No email / No phone
Status: Recruiting
Gazi Universitesi Tip Fakultesi (Gazi University Faculty of Medicine) - Gazi Hastanesi (Gazi Hospital)
Ankara, Turkey
No email / No phone
Status: Recruiting
Kaiser Permanente Medical Center
Vallejo, California, 94589, United States
No email / No phone
Status: Recruiting
OPN Healthcare, Inc.
Glendale, California, 91203, United States
No email / No phone
Status: Recruiting
University of Colorado Hospital - Anschutz Cancer Pavilion
Aurora, Colorado, 80045, United States
No email / No phone
Status: Recruiting
D&H Cancer Research Center
Margate, Florida, 33054, United States
No email / No phone
Status: Recruiting
H. Lee Moffitt Cancer Center
Tampa, Florida, 33612, United States
No email / No phone
Status: Not yet recruiting
Brcr Global
Plantation, Florida, 33324, United States
No email / No phone
Status: Recruiting
Columbia University Medical Center
New York, New York, 10032, United States
No email / No phone
Status: Recruiting
NYU Laura & Issac Perlmutter Cancer Center
New York, New York, 10016, United States
No email / No phone
Status: Recruiting
The Ohio State University
Columbus, Ohio, 43210, United States
No email / No phone
Status: Recruiting
Gabrail Cancer Center Research
Canton, Ohio, 44718, United States
No email / No phone
Status: Recruiting
Providence Portland Medical Center
Portland, Oregon, 97213, United States
No email / No phone
Status: Completed
MD Anderson cancer center
Houston, Texas, 77030, United States
No email / No phone
Status: Recruiting
USOR - Texas Oncology--Weslaco
Weslaco, Texas, 78596, United States
No email / No phone
Status: Recruiting
USOR - Texas Oncology - Baylor Charles A. Sammons Cancer Center
Dallas, Texas, 75246, United States
No email / No phone
Status: Recruiting
University of Virginia Comprehensive Cancer Center
Charlottesville, Virginia, 22908, United States
No email / No phone
Status: Recruiting
