More cancer types, precise mutation matching

August 8, 2025 Michael Gensheimer

I'm excited to share three updates to HealthScout that will help more patients find clinical trials that may be right for them.

Expanding Beyond Lung Cancer to Breast and Colon Cancer

We launched HealthScout for clinical trials for non-small cell lung cancer. Today, we’re expanding to include advanced/metastatic breast cancer and colon cancer trials. These three cancers are leading causes of cancer death in the United States.

A Fully Automated Trial-Eligibility Pipeline

What made this expansion possible is an improvement in how we process trial eligibility criteria. We’ve built a fully automated pipeline that turns each trial's complex eligibility text into precise computer code, faster and more accurately than before.

Here's how it works:

We use the most advanced large language models and instruct them to think deeply about every detail in the eligibility criteria. For each trial, the system generates multiple candidate versions of the code. A separate module then reviews these versions and selects the best one. This approach has significantly reduced error rates, allowing us to publish new trials much faster.

We did careful validation of the accuracy of the new system. For 25 trials, we had a doctor manually review the computer code and make any needed edits. The doctor made minor edits for some of the trials. We created 12 patient profiles with a variety of cancer situations, and checked which patients were eligible for which trials. Across 300 trial-patient pairs, the computer and human code perfectly agreed on whether the patient was eligible. I was so excited to see these results because they meant that we will be able to use this technology to expand HealthScout to many more cancer types in the near future.

New Features for Mutation-Specific Trial Matching

We’ve also rolled out features that make it easier to identify the trials most likely to be a good fit for a patient. Several oncologists have asked us for tools to better find trials for patients with specific cancer mutations such as BRAF V600E or EGFR exon 20 insertion.

Here’s what’s available now:

Baseline matching: HealthScout already matches trials based on general mutation status like EGFR positive or KRAS negative.

Subtype alerts: If a trial is only for a specific subtype, such as KRAS G12C, you’ll now see an alert in the trial list:

⚠️ Needed to verify eligibility: Requires KRAS G12C mutation

Search by mutation: You can type a specific mutation like EGFR exon 20 insertion into the search bar in the trials list to quickly narrow down the list.

While we don’t yet automatically match patients to trials based on these subtypes, this is on our roadmap.

Conclusion

I hope you will find these updates useful. Please let us know what you think! Please email us any feature requests or feedback at [email protected]